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Invokana vs Jardiance

Drug facts and comparison

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Medically reviewed by  Jamie Winn, PharmD

Uses

  • An adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus
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  • As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus
  • To reduce the risk of cardiovascular death in adults with type 2 diabetes mellitus and established cardiovascular disease
  • To reduce the risk of cardiovascular death plus hospitalization for heart failure in adults with heart failure and reduced ejection fraction
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Summary

Brand name: Invokana
Brand name: Jardiance
Manufacturer: Janssen Pharmaceuticals, Inc.
Manufacturer: Boehringer Ingelheim and Eli Lilly and Company
Active ingredient: canagliflozin
Active ingredient: empagliflozin

Side Effects

Most common

  • Nausea
  • Constipation
  • Genital yeast infections
  • Urinary tract infections
  • Hypoglycemia

More serious

  • Allergic reactions
  • Kidney failure
  • Diabetic ketoacidosis

Most common

  • Genital yeast infections (thrush) in both men and women
  • Need to urinate more often and urinating more than usual
  • Feeling more thirsty than usual
  • Itching
  • A skin rash – this may be itchy and include raised bumps and blisters that leak fluid, and may cause your skin to redden
  • An increase in cholesterol levels (this may show up in blood tests)

More serious

  • Severe allergic reactions to the medication
  • A rare but serious bacterial infection that damages tissue under the skin (necrotizing fasciitis) in the area between the anus and genitals (perineum)
  • Diabetic ketoacidosis, a potentially life-threatening condition where your body breaks down too much fat too quickly, causing you to produce high levels of blood acids called ketones
  • Hypoglycemia – your blood sugar falling too low – particularly when used with other medications like insulin or sulfonylurea
  • An increased risk of serious urinary tract infections
  • A high and potentially harmful increase in your cholesterol levels
  • Dehydration

Drug Interactions

Severe interactions
  • Gatifloxacin
  • Morphine
Serious interactions
  • Beta-blockers – atenolol, bisoprolol, propranolol, sotalol
  • Calcium channel blockers – amlodipine, felodipine, nifedipine
  • Diuretics – bendroflumethizaide, bumetanide, furosemide
  • ACE inhibitors – captopril, enalapril, ramipril
  • Corticosteroids – betamethasone, fludrocortisone, prednisolone
  • Anticonvulsants – carbamazepine, phenytoin, phenobarbital
Moderate interactions
  • Topical steroid treatments
Severe interaction
  • Antibiotics for bacterial infections such as gatifloxacin
  • Bexarotene used to treat skin cancer
Serious interaction
  • Beta-blockers – atenolol, bisoprolol, propranolol, sotalol
  • Calcium channel blockers – amlodipine, felodipine, nifedipine
  • Diuretics – bendroflumethizaide, bumetanide, furosemide
  • ACE inhibitors – captopril, enalapril, ramipril
  • Corticosteroids – betamethasone, fludrocortisone, prednisolone
  • Anticonvulsants – carbamazepine, phenytoin, phenobarbital
Moderate interaction
  • Topical steroid treatments

Warnings

You should not use Invokana if you:

  • Are allergic to the active ingredient canagliflozin
  • Are allergic to any of the other ingredients in Invokana
  • Have type 1 diabetes
  • Are breastfeeding

You should talk to your doctor before using Invokana if you:

  • Have diabetic ketoacidosis (a diabetes complication that can cause rapid weight loss, nausea, and vomiting)
  • Have had a serious heart condition or have ever had a stroke
  • Have severe liver problems
  • Have severe kidney problems or are on dialysis
  • Have had a lower limb amputation
  • If you are under 18 years of age
  • Are pregnant or are trying to get pregnant
  • Are intolerant of some sugars

You should not use Jardiance if you:

  • Are allergic to the active ingredient empagliflozin
  • Are allergic to any of the other ingredients in Jardiance
  • Have type 1 diabetes (Jardiance is for type 2 diabetes only)
  • Are under 18 years of age

You should talk to your doctor before using Jardiance if you:

  • Have any liver or kidney problems
  • Have or have ever had problems with your pancreas, like pancreatitis or surgery on your pancreas
  • Have a history of urinary tract infections or any problems with urination
  • Often drink alcohol, or drink a lot of alcohol in a short period of time (“binge” drinking)
  • Are going to have surgery in the near future
  • Are eating less than usual or have changed your diet
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed

Dosage

Once daily

Once daily

Cost

30, 300mg Invokana tablets will cost around $600.

30, 10 mg Jardiance tablets will cost around $675.

FAQs

Invokana and Jardiance are brand names for prescription drugs used for the treatment of high blood sugar levels in people with type 2 diabetes. Both Jardiance and Invokana are diabetes drugs classed as sodium-glucose co-transporter 2 inhibitors (SGLT2 inhibitors).

Here we will explain how they work, their similarities and differences, their side effects, and more. This should provide you with the basics to better understand your options.

What is Invokana?

Invokana is an FDA-approved (U.S. Food and Drug Administration) medication manufactured by Janssen Pharmaceuticals, Inc. It’s usually prescribed with exercise and diet changes to help manage blood sugar levels. Invokana helps with type 2 diabetes by increasing the amount of sugar that’s removed from your body in your urine. This helps to keep your blood sugar levels lower. Invokana is taken orally as a tablet swallowed with water.

With type 2 diabetes, a lack of insulin, or insulin no longer working effectively as it should, causes you to have too much sugar in your blood. Having high blood sugar can make you feel hungry, thirsty, and tired. But, over time, high blood sugar can have more serious consequences. It can cause a range of health problems, including heart attacks, strokes, and kidney failure.

The active ingredient in Invokana is called canagliflozin. It helps to lower your blood sugar by blocking a process in your body that reabsorbs sugar (glucose) from your urine. This increases the amount of sugar in your urine and causes you to lose more than you would normally do when you urinate. Used alongside exercise and improvements in your diet, and sometimes other diabetes medications, canagliflozin can help you maintain a lower blood sugar level.

Invokana dosage

Invokana is available in tablet form, in the following doses: 100 mg, and 300 mg.

The recommended starting dose for Invokana is 100 mg once daily, taken before the first meal of the day. A dose adjustment for patients with renal impairment may be required.

What is Jardiance?

Jardiance is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Boehringer Ingelheim Pharmaceuticals, Inc. Jardiance is also a diabetes medicine prescribed to adults with type 2 diabetes. It’s used to reduce blood sugar levels when used alongside exercise and diet changes, and to reduce the risk of death by heart disease.

  • In combination with diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus
  • To reduce the risk of cardiovascular death in adults with type 2 diabetes mellitus and established cardiovascular disease
  • To reduce the risk of cardiovascular death plus hospitalization for heart failure in adults with heart failure and reduced ejection fraction

Jardiance can help you lower your blood glucose levels when taken alongside dietary and lifestyle changes. It causes you to excrete more sugar in your urine than you would normally. This lowers your blood sugar and helps to reduce your risk of health conditions like cardiovascular disease.

The active ingredient in Jardiance is called empagliflozin. It lowers your blood sugar levels by causing you to lose more sugar in your urine than you usually would. Your kidneys help recycle sugar back into your blood from your urine, with the help of a protein called SGLT-2. Empagliflozin blocks this protein from working, reducing how much sugar your kidneys recycle. This makes you lose more sugar in your urine, rather than it being excreted back into your blood.

Jardiance dosage

Jardiance is available in tablet form, in the following doses: 10 mg, and 25 mg. The recommended dose of Jardiance is 10 mg once daily, in the morning, with or without food.

Common side effects of Invokana and Jardiance

The most common side effects of Invokana in clinical trials include:

  • Nausea
  • Constipation
  • Genital yeast infections
  • Urinary tract infections
  • Hypoglycemia (low blood sugar)

More serious side effects of Invokana include:

  • Allergic reactions
  • Kidney failure
  • Diabetic ketoacidosis – a potentially life-threatening condition where your body breaks down too much fat too quickly, causing you to produce high levels of blood acids called ketones

The most common side effects of Jardiance in clinical trials include:

  • Genital yeast infections in both men and women
  • Needing to urinate more often and urinating more than usual
  • Feeling more thirsty than usual
  • Itching
  • A skin rash – this may be itchy and include raised bumps and blisters that leak fluid, and may cause your skin to redden
  • An increase in cholesterol levels

More serious side effects of Jardiance include

  • Severe allergic reactions to the medication
  • Low blood pressure (hypotension)
  • A rare but serious bacterial infection that damages tissue under the skin (necrotizing fasciitis) in the area between the anus and genitals (perineum)
  • Diabetic ketoacidosis
  • Hypoglycemia
  • An increased risk of serious urinary tract infections
  • Increased risk of bone fracture
  • A high and potentially harmful increase in your cholesterol levels
  • Dehydration

These aren’t all the side effects Invokana or Jardiance can cause. You can find more details in the patient leaflet that comes with your medication. If you have any concerns about side effects, talk to your physician or pharmacist.

Invokana and Jardiance drug interactions

Invokana can interact with other medications. These include:

  • Other antidiabetic drugs
  • Medications used to lower your blood pressure
  • Carbamazepine, phenytoin, or phenobarbital to control seizures
  • Efavirenz or ritonavir to treat HIV infection
  • Rifampicin to treat tuberculosis
  • Cholestyramine to reduce cholesterol
  • Digoxin or digitoxin used to treat certain heart problems
  • The blood thinner dabigatran
  • St John’s wort

Jardiance can interact with other medications. These include:

  • Any other diabetes medications, like insulin or sulfonylureas
  • Diuretics
  • Corticosteroids
  • Estrogens
  • Oral contraceptives
  • Nicotinic acid
  • Calcium channel blocking drugs
  • Rifampin

Invokana and Jardiance can interact with other medications. This can change how Invokana and Jardiance and other medications work and can make side effects more likely. Tell your prescribing physician about all your drugs, including vitamins and dietary supplements.

Invokana and Jardiance contraindications

You should not use Invokana if you:

  • Are allergic to the active ingredient canagliflozin
  • Are allergic to any of the other ingredients in Invokana
  • Have type 1 diabetes (Invokana is for type 2 diabetes)
  • Are breastfeeding or planning to breastfeed

Talk to your doctor before using Invokana if you:

  • Have diabetic ketoacidosis (a diabetes complication that can cause rapid weight loss, nausea, and vomiting)
  • Have had a serious heart condition or have ever had a stroke
  • Have severe liver problems
  • Have severe kidney problems or are on dialysis
  • Have had a lower limb amputation
  • If you are under 18 years of age
  • Are pregnant or are trying to get pregnant
  • Are intolerant of some sugars

You should not use Jardiance if you:

  • Are allergic to the active ingredient empagliflozin
  • Are allergic to any of the other ingredients in Jardiance
  • Have type 1 diabetes (Jardiance is for type 2 diabetes only)
  • Are under 18 years of age

Talk to your doctor before using Jardiance if you:

  • Have liver or kidney disease
  • Have or have ever had problems with your pancreas, like pancreatitis or surgery on your pancreas
  • Have a history of urinary tract infections or any problems with urination
  • Often drink alcohol, or drink a lot of alcohol in a short period of time
  • Are going to have surgery in the near future
  • Are eating less than usual or have changed your diet
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed

Other drugs for type 2 diabetes

If you have any concerns about Invokana or Jardiance side effects, talk to your physician, or pharmacist for medical advice. Also inform your healthcare provider about any medical conditions, supplements, and over-the-counter meds you are taking. You are also encouraged to report side effects to the FDA: visit http://www.fda.gov/medwatch or call 1-800-FDA-1088.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.
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