If you have Type 2 diabetes, there are medications such as Ozempic and Trulicity that can help lower your blood glucose levels. It is not always easy to know how these medications work and the differences between them. Your doctor will prescribe you the most appropriate medication for your needs, but it is still important to better understand the diabetes medicines available to you.
Both Ozempic and Trulicity are injectable Type 2 diabetes medications. But are they the same? Here we focus on Ozempic vs Trulicity and explain clearly and simply what they are, how they work, and the similarities and differences between them.
Understanding GLP-1 receptor agonists
Ozempic and Trulicity belong to a group of medications called GLP-1 (glucagon-like peptide-1) receptor agonists. When you eat and drink, your body produces digestive hormones called incretins. GLP-1 is one of these incretin hormones.
GLP-1 incretin hormones help lower your blood glucose levels when you digest food in three ways. They:
- Stimulate your body to produce more insulin
- Prevent the release of glucagon
- Slow down how quickly your body digests food
Ozempic and Trulicity act in the same way as GLP-1 incretin hormones. By stimulating the same receptors, they cause your body to release more insulin, less glucagon, and digest food slower.
Trulicity and Ozempic are more active when you have consumed food and are digesting it. They become less active when you stop eating or drinking. They help to ensure your blood glucose levels do not fall too low (hypoglycemia).
What is the difference between Trulicity and Ozempic?
So, what is the difference between Trulicity and Ozempic? Both are GLP-1 receptor agonist medications used to treat type 2 diabetes. They are taken by injection under the skin (subcutaneous injection) using a self-injecting pen device, and they work in the same way. Although Ozempic and Trulicity are similar, there are key differences between them.
The active ingredients they contain are the most important difference between Ozempic and Trulicity. Ozempic contains a GLP-1 receptor agonist called semaglutide, whilst Trulicity contains a GLP-1 receptor agonist called dulaglutide. Semaglutide and dulaglutide do work in similar ways, but they are not identical. You may respond to them differently.
The doses prescribed for each drug also vary. Ozempic can be prescribed in 0.25 mg, 0.5 mg, and 1 mg doses, whereas Trulicity can be prescribed in larger 0.75 mg, 1.5 mg, 3 mg, and 4.5 mg doses. Ozempic is typically taken in smaller doses, as independent research has shown it to be more effective than Trulicity.
How effective is Ozempic vs Trulicity?
Both Ozempic and Trulicity are proven and effective treatments for type 2 diabetes.
However, in independent research that compared the two medications, Ozempic was found to be more effective than Trulicity. The study was conducted on 1,201 patients with type 2 diabetes from 194 hospitals in 16 countries. Over the 40-week trial, Ozempic lowered blood glucose levels further than Trulicity on average and caused more weight loss. No noteworthy differences in side effects were found between Ozempic and Trulicity.
Although Ozempic was found to be more effective than Trulicity on average, it is important to note that people respond to medications differently. This means some people will get better results from Trulicity and some from Ozempic.
Ozempic vs Trulicity cost comparison
Ozempic and Trulicity are both bought as packages of self-injecting pens. The price you pay for Ozempic or Trulicity without insurance will depend on the number of pens per pack and the strength of the pens. Prices will also vary by retailer. On average, Ozempic and Trulicity prices are similar, but Ozempic can be slightly more expensive:
- 2 mg/1.5 ml pre-filled Ozempic Pen costs $899 on average for 1.5 milliliters
- 0.75 mg/0.5 ml pre-filled Trulicity Pen costs $891 on average for 2 milliliters
The cost of Ozempic and Trulicity, if you have insurance, will depend on the details of your healthcare plan. Contact your pharmacist or insurance provider to calculate your copay with your current insurance.
If you’re approved for Ozempic or Trulicity assistance through NiceRx, you could get your prescription for only $49 per month. We may be able to help you even if you have insurance. Fill in our online enrollment application to find out more.