- Type 2 diabetes
$49 per month
- Adults and children 10 years or older with Type 2 diabetes mellitus
Drug facts and comparison
You should not use Rybelsus if you:
You should talk to your doctor before using Rybelsus if you:
You should not use Metformin if you:
You should talk to your doctor before using Metformin if you:
Once, twice or three times a day
30, 3 mg Rybelsus oral tablet will cost around $950
14, 500 mg Metformin oral tablets will cost $11
Metformin is recommended as the first-line treatment for Type 2 diabetes mellitus by the American Diabetes Association. Metformin is a generic diabetes treatment used as part of a larger treatment plan for Type 2 diabetes. It can be used alone or in combination with other medications.
Rybelsus is the brand name for a prescription diabetes drug containing semaglutide, also used to help with blood sugar control in adults with type 2 diabetes mellitus. It belongs to a class of drugs called glucagon-like peptide-1 (GLP-1) agonists.
Here we will explain how they work, their similarities and differences, their side effects, and more. This should provide you with the basics to better understand your options.
Rybelsus (oral semaglutide) is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Novo Nordisk Inc. It is given to adults with type 2 diabetes to help lower their blood sugar (glucose) when used with exercise and diet changes.
Common, serious, long-term complications of type 2 diabetes are cardiovascular disease, which can lead to problems like heart attack, stroke, and even death. People with type 2 diabetes are at twice the risk of cardiovascular disease as people without diabetes.
Rybelsus is a non-insulin medication that causes your pancreas to produce more insulin, helping to lower your blood sugar levels. You take Rybelsus in tablet form, usually once a day when you first wake up but make sure you always use your Rybelsus as directed by your doctor or pharmacist.
The active ingredient in Rybelsus is called semaglutide. It’s a non-insulin drug that can help lower your blood glucose levels by stimulating the cells in your pancreas that produce insulin (called beta cells). Rybelsus belongs to a class of drugs called glucagon-like peptide-1 receptor agonists (GLP-1 agonists). When you take Rybelsus, semaglutide molecules attach to beta cells in your pancreas at sites called glucagon-like peptide-1 receptors (it is classed as a GLP-1 receptor agonist). The semaglutide stimulates these receptors, which makes the beta cells produce more insulin, helping to lower your blood sugar after you’ve eaten.
Semaglutide also encourages the growth of more beta cells in your pancreas, allowing your pancreas to produce higher levels of insulin, reversing any declines in your body’s insulin production.
Rybelsus is available in tablet form, in the following doses: 3 mg, 7 mg, and 14 mg dose.
Take Rybelsus at least 30 minutes before your first food, beverage, or other oral medications of the day with not more than 4 ounces of water only. Swallow the tablets whole. Do not cut, crush, or chew the tablets. The starting dosage is 3 mg once daily for 30 days, followed after 30 days by an increase to 7 mg once daily. The dose may be increased to 14 mg once daily after another 30 days if needed.
Read the full prescribing information and always speak with a healthcare professional for medical advice about any changes to your dose so they can monitor and evaluate your condition.
Metformin is an FDA (U.S. Food and Drug Administration) approved medication manufactured by various generic manufacturers. Metformin is in the drug class of biguanide, used as a first-line treatment for diabetes because of its mode of action in increasing your body’s insulin sensitivity. Also, metformin does not cause weight gain. Metformin effectively lowers fasting blood sugar and hemoglobin A1c levels.
It is used in combination with changes to diet and exercise to improve glycemic control in adults and pediatric patients with type 2 diabetes mellitus. It works by reducing the amount of glucose absorbed from your intestines, decreasing how much glucose is made in your liver, and improving your insulin sensitivity.
Metformin is available as an immediate release or extended-release oral tablet, or as an oral suspension.
Metformin is taken with a meal unless your doctor tells you otherwise. Do not crush, chew, or break the extended-release tablet. Swallow it whole. Your doctor may prescribe a glucagon injection kit in case you have severe hypoglycemia. You may also be prescribed extra vitamin B12 while you are taking this medicine.
The most common side effects of Rybelsus in clinical trials compared to placebo include:
More serious side effects of Rybelsus include:
The most common side effects of metformin in clinical trials include:
More serious side effects of metformin include
These aren’t all the side effects Rybelsus or metformin can cause. You can find more details in the patient leaflet that comes with your medication. If you have any concerns about side effects, talk to your physician or pharmacist.
Rybelsus can interact with other medications. These include:
Metformin can interact with other medications. These include:
Rybelsus and metformin can interact with other medications. This can change how Rybelsus and metformin and other medications work and can make side effects more likely. Tell your prescribing physician about all your drugs, including vitamins and dietary supplements.
You should not use Rybelsus if you:
Talk to your doctor before taking Rybelsus if you:
You should not use metformin if you:
Talk to your doctor before using metformin if you:
If you have any concerns about Rybelsus or metformin side effects, or your diabetes care, talk to your physician, or pharmacist for medical advice. Also inform your healthcare provider about any medical conditions, supplements, and over-the-counter meds you are taking. You are also encouraged to report side effects to the FDA: visit http://www.fda.gov/medwatch or call 1-800-FDA-1088.