Aplenzin Coupon & Prices

Is your Aplenzin medication too expensive? Start receiving your medication for only $49 per month.*

Complete a free online enrollment application to find out if you’re eligible to pay only $49 per month for your Aplenzin medication with our help.

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  • NiceRx Benefit
    Secure: Your personal and medical information is safe with us
  • NiceRx Benefit
    Convenient: We manage the whole process and we’re here to assist you
  • NiceRx Benefit
    Ongoing refills: We request your medication refills on your behalf
  • NiceRx Benefit
    Secure: Your personal and medical information is safe with us
  • NiceRx Benefit
    Convenient: We manage the whole process and we’re here to assist you
  • NiceRx Benefit
    Ongoing refills: We request your medication refills on your behalf

NiceRx works with your healthcare provider to help you access affordable medications directly from U.S. pharmaceutical companies.

How it works

  • Enroll online

    Get started by filling out the online enrollment application to find out if you are eligible for assistance.

  • Pre-qualification

    NiceRx verifies your eligibility for medication assistance and notifies you if you are pre-qualified. The pharmaceutical company provides your medication for free, and you only pay our service fee.

  • Submit documents

    We will request documents to be submitted by you and your healthcare provider that are required by the pharmaceutical company to complete your enrollment.

  • Receive medication

    Once approved, the pharmaceutical company typically ships a 90-day supply of medication to your home or healthcare provider’s address. Final acceptance is determined by the pharmaceutical company.

Medically reviewed by  Jamie Winn, PharmD

Your monthly Aplenzin cost savings if eligible

If you are eligible for the Aplenzin patient assistance program, the cost of your medication will be free. We only charge $49 per month for each medication, to cover our service fees. You could receive your Aplenzin prescription for just $49 a month, regardless of the retail price of your medication.

Am I eligible for the Aplenzin patient assistance program?

We will review your application to determine whether you are eligible for the Aplenzin patient assistance program. Each program has its own eligibility criteria which are set by the pharmaceutical companies, however, the factors considered by most programs are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Aplenzin patient assistance program?

We make it as easy as possible to apply for the Aplenzin patient assistance program. The first step is to complete our enrollment application. Tell us about any medications you are taking, including Aplenzin. We will also ask for details about your healthcare provider, insurance, and your household income. This information is required by the pharmaceutical manufacturers who ship your medication.

If we determine that you may be eligible for Aplenzin assistance, we will handle the application process for you. We will work directly with your healthcare provider to prepare your application documents. Once we have received the signed application and supporting documents, we will submit them to the patient assistance program on your behalf. Our service continues once you are enrolled in the Aplenzin patient assistance program, and we will automatically request your Aplenzin medication refills for up to 1 year.

Is NiceRx an Aplenzin coupons provider?

We are a service provider that helps eligible individuals access the Aplenzin patient assistance program. That means that we do not offer printable Aplenzin manufacturer coupons, Aplenzin discounts, or free Aplenzin samples. We are not an Aplenzin coupon provider or Aplenzin discount card. Our service extends to assisting eligible individuals to access the medications they need through patient assistance programs.

Can NiceRx help me get Aplenzin if I have insurance?

We may be able to help you to access Aplenzin patient assistance in a variety of circumstances. This includes when your insurance company will not pay for your Aplenzin medication or if you have a high copay or coinsurance responsibility. We may also be able to help you if you do not have insurance. Please apply online to find out more.

How much does Aplenzin cost without insurance?

Aplenzin cost without insurance will vary depending on where you buy it. As a guide, Aplenzin oral tablets, extended-release (hydrobromide 174 mg/24 hours) usually cost $1,800 for 30. With NiceRx you will pay a flat monthly fee of $49, regardless of the retail price of your medication.

How much does Aplenzin cost with insurance?

The copay for Aplenzin with insurance depends on the terms of your healthcare plan. To find out how much this is, your healthcare provider or pharmacist will be able to calculate your copay with your current insurance.

What is Aplenzin?

Aplenzin is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Bausch Health Companies Inc. Aplenzin is an aminoketone antidepressant indicated for the treatment of major depressive disorder (MDD). It may also be used to prevent seasonal affective disorder (SAD), a type of depression that occurs each year at the same time (e.g. during the winter season). It is thought that Aplenzin may work by restoring the balance of dopamine and norepinephrine in the brain.

Aplenzin is not FDA-approved to treat sexual dysfunction, including trouble getting an erection or achieving an orgasm. The American Psychiatric Association does however recommend using bupropion off-label to treat sexual dysfunction when it’s a side effect of a selective serotonin reuptake inhibitor (SSRI) medication.

Antidepressants have been seen to increase the risk compared to placebo of suicidal thoughts and behavior in children, adolescents, and young adults in studies of major depressive disorder and other psychiatric disorders.

What doses of Aplenzin are available?

Aplenzin is available in extended-release tablet form, in the following doses: 174 mg, 348 mg, 522 mg.

Increase the dose of Aplenzin gradually to reduce the risk of seizures and other effects. The recommended starting dose for adults is 174 mg/day, to achieve a target dose of 348 mg/day.

When switching from other brands such as Wellbutrin, Wellbutrin SR, or Wellbutrin XL patients should be given an equivalent daily dose, if possible. Patients with impaired hepatic or renal function should take a reduced dose or frequency of Aplenzin.

Please read the full medication guide and always speak with your healthcare provider about any changes to your dose so they can monitor and evaluate your condition.

Aplenzin active ingredients

Aplenzin contains bupropion hydrobromide (HBR) as the active ingredient.

Aplenzin side effects

The most common side effects of Aplenzin in clinical trials compared to placebo include:

  • Dry mouth, nausea
  • Trouble sleeping
  • Dizziness
  • Pharyngitis, stuffy nose
  • Abdominal pain, constipation
  • Agitation, anxiety, tremor, palpitation, sweating
  • Tinnitus
  • Myalgia
  • Anorexia
  • Urinary frequency, rash

In rare instances, Aplenzin can cause more serious side effects. These can include:

  • Increased risk of suicide
  • Risk of activation of psychosis and/or mixed/manic episodes – screen patients for bipolar disorder
  • Risk of seizure – this can be minimized by limiting the daily dose
  • Hepatic impairment
  • Risk of neuropsychiatric events such as delusions, hallucinations, psychosis, concentration disturbance, paranoia, confusion
  • Loss of appetite should be considered if weight loss is a concern
  • Risk of anaphylactic reactions
  • Risk of severe hypertension (high blood pressure)

Your doctor will assess the benefits of using Aplenzin against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Aplenzin to the FDA. Visit, or call 1-800-FDA-1088.

Aplenzin drug interactions

Aplenzin can interact with other medications. These include:

  • CYP2B6 substrates or inhibitors such as cyclophosphamide, orphenadrine, thiotepa, efavirenz, fluvoxamine, norfluoxetine, nelfinavir, paroxetine, ritonavir, sertraline
  • Carbamazepine, phenobarbital, phenytoin
  • Antidepressants – nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, sertraline
  • Antipsychotics – haloperidol, risperidone, thioridazine
  • Beta-blockers – metoprolol
  • Type 1C antiarrhythmics – propafenone, flecainide
  • MAO inhibitors
  • Levodopa, amantadine
  • Drugs that lower seizure threshold
  • Alcohol – minimize consumption or avoid

This list is not exhaustive and other prescription drugs may interact with Aplenzin.

Aplenzin contraindications

You should not use Aplenzin if you:

  • Are allergic to the active ingredient bupropion hydrobromide
  • Have had an allergic reaction to any of the other ingredients in Aplenzin
  • Have a seizure disorder
  • Are using Zyban (bupropion hydrochloride) sustained-release tablets, Wellbutrin (bupropion HCl), Wellbutrin SR (bupropion HCl) tablets, or any other medications that contain bupropion
  • Have a current or prior diagnosis of bulimia or anorexia nervosa
  • Have suddenly stopped drinking alcohol, or taking sedatives such as benzodiazepines
  • Use MAO inhibitors (MAOIs). At least 14 days should elapse between discontinuation of an MAO inhibitor and initiation of Aplenzin
  • Have had an eating disorder such as anorexia or bulimia

Talk to your doctor about any other medical conditions before using Aplenzin if you:

  • Are taking any of the medications that could interact with Aplenzin
  • Have renal Impairment
  • Have hepatic impairment
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed

Aplenzin generic

Aplenzin is the trademark brand name for bupropion hydrobromide manufactured by Bausch Health Companies Inc. A generic version of bupropion hydrobromide is available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Aplenzin savings through NiceRx.

Related medications

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*Qualifying persons may obtain medications directly from patient assistance programs without any out-of-pocket cost (or for less than $49 per medication). However, our monthly flat rate of just $49 per medication spares you the hassle of tracking the different programs and filling out all the required paperwork for each program. Subject to medication availability and acceptance by the pharmaceutical companies. NiceRx is not responsible for any delays or rejection by the pharmaceutical companies.

Enrollees enjoy a full-service solution, as NiceRx assists them and their physicians with the entire process. We prepare all required documents for the physician to sign, help enrollees manage all prescription refills, monitor eligibility criteria, and maintain enrollment.

**If you do not receive medications because you were determined to be ineligible for the prescription assistance by the applicable pharmaceutical companies and you have a letter of denial, we will refund any fees you paid toward medications for which you did not qualify to receive prescription assistance (“Refund”).

To receive a refund, you must send the letter of denial to us by fax to 888-517-7444, or by e-mail to [email protected] within 30 days of your receipt of such letter. The Refund is your sole and exclusive remedy for any fees you may wish to dispute.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.