Arranon Patient assistance program

Your monthly Arranon cost savings if eligible

If you are eligible to receive your Arranon prescription through the patient assistance program, your medication will be free. We charge a flat monthly service fee of $49 per medication to cover the cost of our services.

Am I eligible for Arranon patient assistance?

To be eligible for the Arranon patient assistance program, you will need to meet specific eligibility criteria set by the pharmaceutical company. At NiceRx, we review each Arranon enrollment application individually. The main factors considered are:

• I am a permanent, legal resident of the United States or Puerto Rico
• I am uninsured or my insurance doesn’t cover my medication
• I meet certain income eligibility requirements

How do I apply for the Arranon patient assistance program?

Applying for the Arranon patient assistance program through NiceRx is simple. Begin by completing the enrollment application on our website. We will ask for details about your healthcare provider, your insurance plan, and your household income. This information is required by the pharmaceutical manufacturers that supply your medication. We may be able to help you access patient assistance for other medications as well as Arranon, so please tell us about any medications that you have been prescribed.

If we determine that you may be eligible for Arranon assistance, we will handle the full enrollment process on your behalf. We will work with your healthcare provider to prepare and submit all the documents required for you to enroll. If you are successfully enrolled in the Arranon patient assistance program, we will also request your Arranon medication refills on your behalf for up to 1 year. At the end of your enrollment period, we will contact you for updated details and seek to re-enroll you in the program.

Is NiceRx an Arranon coupon provider?

NiceRx does not provide Arranon coupons, discount cards or copay cards. We do not offer printable Arranon manufacturer coupons, Arranon discounts, rebates, Arranon savings cards, trial offers, or free samples. We are a service provider that helps eligible individuals access patient assistance programs. Our service cost is $49 a month per medication, so you will likely save more on your Arranon medication with NiceRx.

Can NiceRx help me get Arranon cheaper if I have insurance?

NiceRx may be able to help you access Arranon patient assistance if:

• You have a high copay or coinsurance responsibility for Arranon
• Your insurance company will not pay for your Arranon prescription
• You do not have insurance

Complete your enrollment application online to find out more.

How much does Arranon cost without insurance?

Arranon prices without insurance will vary by retailer. As a guide, Arranon intravenous solution (5 mg/mL) will typically cost around $785 for 50 milliliters.

How much does Arranon cost with insurance?

Your individual healthcare plan will determine the copay of Arranon with insurance. To find out what you will need to pay, contact your pharmacist or insurance provider. They will be able to calculate your copay with your current insurance.

What is Arranon?

Arranon is an FDA (U.S. Food and Drug Administration) approved medication distributed by Novartis Pharmaceuticals.

It is classed as a nucleoside metabolic inhibitor for the treatment of T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma (T-LBL) in patients who have not responded to or have relapsed after treatment with at least two chemotherapy regimens. This use is on the basis of induction of complete responses.

Severe neurologic adverse reactions have been reported when using this treatment. These include altered mental states such as severe somnolence, convulsions, and peripheral neuropathy. Adverse reactions with demyelination, and ascending peripheral neuropathies similar in appearance to Guillain-Barré syndrome have also been reported.

What doses of Arranon are available?

Arranon is available in injection form, in the following doses: 250 mg/50 mL (5 mg/mL) vial.

Nelarabine injection for adult patients is administered intravenously over 2 hours on days 1, 3, and 5 repeated every 21 days. The pediatric dose is administered intravenously over 1 hour daily for 5 consecutive days and repeated every 21 days.

Monitor for neurologic adverse reactions and discontinue treatment for neurologic adverse reactions of NCI common toxicity criteria grade 2 or greater.

Measures should be taken to stop hyperuricemia such as hydration, urine alkalinization, and prophylaxis with allopurinol. Arranon is not recommended in pediatric patients younger than 1 year of age.

Please read the full patient information and always speak with your healthcare provider about any changes to your dose so they can monitor and evaluate your condition.

Arranon active ingredients

Arranon contains nelarabine a prodrug of the cytotoxic deoxyguanosine analogue, 9-β-Darabinofuranosylguanine (ara-G). Nelarabine is classed as an antimetabolite. Its mechanism of action is on specific cell cycles and to attack cells at very specific phases in the cycle. Antimetabolites are classed based on the substances with which they interfere. Nelarabine is classed as an adenosine deaminase inhibitor.

Arranon side effects

The most common side effects of Arranon in clinical trials include:

• Anemia, thrombocytopenia, neutropenia including febrile neutropenia, leukopenia
• Nausea, diarrhea, vomiting, constipation
• Fatigue, pyrexia, cough, and dyspnea
• Neurological adverse reactions include somnolence, dizziness, peripheral neurologic disorders, hypoesthesia, headache, and paresthesia
• Signs of dehydration such as tiredness, thirst, dry mouth, dark and decreased amount of urine, or dizziness
• Unusual bleeding or bruising
• Black or tarry stools, or blood in your stools
• Blood in the urine
• Chest pain or pressure or a fast heartbeat

In rare instances, Arranon can cause more serious adverse effects. These can include:

• Severe neurologic adverse events – extreme sleepiness, somnolence, convulsions, ataxia, confusion, and paresthesias
• Hematologic reactions – complete blood counts including platelets should be monitored regularly
• Fetal harm
• Hematologic
• Tumor Lysis Syndrome (the rapid breakdown of a large number of cancer cells)

Get medical help if you notice any of the following symptoms of a serious allergic reaction, rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, and trouble breathing.

Your doctor will assess the benefits of using Arranon against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Arranon to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Arranon drug interactions

Arranon can interact with other medications. These include:

• Adenosine deaminase inhibitors, such as pentostatin

This list is not exhaustive and other prescription drugs may interact with Arranon. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Arranon contraindications

You should not use Arranon if you:

• Are allergic to the active ingredient nelarabine
• Are allergic to any of the other ingredients in Arranon
• Have recently been given a live vaccine
• Are pregnant or are planning to become pregnant

Talk to your doctor before using Arranon if you:

• Are taking any of the medications that could interact with Arranon
• Have renal impairment or any other kidney problems
• Have hepatic impairment – monitor for toxicities
• Have a nervous system disorder
• Have had prior chemotherapy or radiation treatment of your head, neck, or spinal cord
• Are breastfeeding or are planning to breastfeed

Arranon generic

Arranon is the trademark brand name for nelarabine distributed by Novartis Pharmaceuticals. A generic version of nelarabine is available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Arranon savings through NiceRx.