Brineura Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Brineura cost savings if eligible

If you are eligible for the Brineura patient assistance program you can receive your medication for free. Our monthly service fee of $49 per medication covers the cost of our services in applying for the program and requesting your ongoing refills on your behalf. If you obtain your Brineura through NiceRx, you will only pay $49 a month regardless of the retail price of your medication.

Am I eligible for the Brineura patient assistance program?

You could receive your Brineura without paying the full retail price if you meet the eligibility criteria for assistance. The eligibility requirements are set by the pharmaceutical companies that are providing assistance programs. At NiceRx, we review each application individually, although the main factors considered by most programs are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for Brineura patient assistance?

We do everything that we can to take the hassle and stress out of applying for patient assistance programs. Simply start by filling in our enrollment application. We will ask for details about your healthcare provider, your insurance, and your household income. This information is required by the pharmaceutical companies you are applying to for assistance. We may also be able to help you access patient assistance for other medications that you have been prescribed, so be sure to tell us about any medications you are taking as well as Brineura.

NiceRx will review the information you have provided, and if we determine that you may be eligible for assistance, we will seek to enroll you in the Brineura patient assistance program. We will handle the enrollment process for you by working with your healthcare provider and preparing all the required paperwork for your doctor to sign. We will also request your Brineura medication refills on your behalf for up to 1 year once you are enrolled in the program.

Is NiceRx a Brineura coupons provider?

At NiceRx, we help eligible individuals access the Brineura patient assistance program. This means that we are not a Brineura coupon, a Brineura discount card, or a Brineura copay card provider. We do not offer any medication trial offers, or free Brineura samples.

Can NiceRx help me get Brineura if I have insurance?

We may be able to help you if you have insurance, including if your insurance company will not pay for your Brineura medication, or you have a high copay or coinsurance responsibility. We may even be able to assist if you do not have insurance. Please fill in our enrollment application to find out more.

How much does Brineura cost without insurance?

Brineura costs without insurance will vary depending on how many you buy and the retailer you buy it from. As a guide, Brineura injectable kits (150 mg/5 mL) typically cost around $30,360 for 1 kit. If you obtain your medication through NiceRx, you will pay a flat monthly rate of $49 per medication regardless of its retail price.

How much does Brineura cost with insurance?

The copay of Brineura will vary in line with the specific terms of your healthcare plan. For further details about what you may need to pay, your insurance provider or pharmacist will be able to calculate the copay costs with your current insurance.

What is Brineura?

Brineura is an FDA (U.S. Food and Drug Administration) approved medication manufactured by BioMarin Pharmaceutical Inc. Brineura is a hydrolytic lysosomal N-terminal tripeptidyl peptidase enzyme indicated to slow the loss of ambulation in symptomatic pediatric patients 3 years of age and older with late infantile neuronal ceroid lipofuscinosis type 2 (CLN2 disease), also known as tripeptidyl peptidase 1 (TPP1) deficiency. Brineura is the only enzyme replacement therapy that helps treat CLN2 disease, which is a common form of Batten disease.

What doses of Brineura are available?

Brineura is available in injection form, in the following doses: 150 mg/5 mL (30 mg/mL) solution, two single-dose vials per carton co-packaged with intraventricular electrolytes injection 5 mL in a single-dose vial.

Brineura should be administered by, or under the direction of a physician knowledgeable in intraventricular administration. Brineura is administered to the cerebrospinal fluid (CSF) by infusion via a surgically implanted reservoir and catheter. Pre-treatment of patients with antihistamines with or without antipyretics or corticosteroids is recommended 30 to 60 minutes before the start of infusion. The recommended dosage is 300 mg once every other week as an intraventricular infusion followed by infusion of intraventricular electrolytes over approximately 4.5 hours. Please see the full prescribing information for further drug information.

Always speak with a healthcare professional for medical advice or about any changes to your dose so they can monitor and evaluate your condition.

Brineura active ingredients

Brinurea contains cerliponase alfa as the active ingredient.

Brineura side effects

The most common side effects of Brineura in clinical trials include:

  • Pyrexia
  • ECG abnormalities
  • Decreased CSF protein
  • Vomiting
  • Seizures
  • Hematoma
  • Headache
  • Irritability
  • Pleocytosis
  • Device-related infection
  • Bradycardia
  • Hypotension (low blood pressure)

In rare instances, Brineura can cause more serious side effects. These can include:

  • Intraventricular access device-related complications – inspect the scalp for skin integrity and for signs of intraventricular access device leakage. Do not administer if there are signs of device leakage or infection. Routinely send CSF samples for testing to detect subclinical device-related infections
  • Cardiovascular adverse reactions – monitor vital signs before, during, and post-infusion. Monitor electrocardiogram (ECG) in patients with a history of bradycardia, conduction disorder, or structural heart disease, during the infusion
  • Hypersensitivity reactions including anaphylaxis may occur

Your doctor will assess the benefits of using Brineura against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Brineura to the FDA. Visit, or call 1-800-FDA-1088.

Brineura drug interactions

There is currently no data for Brineura’s interactions with other medications. Tell your healthcare provider about all the medicines you take, including prescription drugs and over-the-counter medicines, vitamins, and herbal supplements.

Brineura contraindications

You should not use Brineura if you:

  • Are allergic to the active ingredient cerliponase alfa
  • Are allergic to any of the other ingredients in Brineura
  • Have acute intraventricular access device-related complications (e.g., leakage, device failure, or device-related infection)
  • Have ventriculoperitoneal shunts
  • Are younger than 3 years of age

Talk to your doctor before using Brineura if you:

  • Are taking any of the medications that could interact with Brineura
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed

Brineura generic

Brineura is the trademark brand name for cerliponase alfa manufactured by BioMarin Pharmaceutical Inc. A generic version of cerliponase alfa is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Brineura savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.