Buphenyl Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Buphenyl cost savings if eligible

If you are eligible to receive your Buphenyl prescription through the patient assistance program, your medication will be free. We charge a flat monthly service fee of $49 per medication to cover the cost of our services.

Am I eligible for Buphenyl patient assistance?

To be eligible for the Buphenyl patient assistance program, you will need to meet specific eligibility criteria set by the pharmaceutical company. At NiceRx, we review each Buphenyl enrollment application individually. The main factors considered are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Buphenyl patient assistance program?

Applying for the Buphenyl patient assistance program through NiceRx is simple. Begin by completing the enrollment application on our website. We will ask for details about your healthcare provider, your insurance plan, and your household income. This information is required by the pharmaceutical manufacturers that supply your medication. We may be able to help you access patient assistance for other medications as well as Buphenyl, so please tell us about any medications that you have been prescribed.

If we determine that you may be eligible for Buphenyl assistance, we will handle the full enrollment process on your behalf. We will work with your healthcare provider to prepare and submit all the documents required for you to enroll. If you are successfully enrolled in the Buphenyl patient assistance program, we will also request your Buphenyl medication refills on your behalf for up to 1 year. At the end of your enrollment period, we will contact you for updated details and seek to re-enroll you in the program.

Is NiceRx a Buphenyl coupon provider?

NiceRx does not provide Buphenyl coupons, discount cards or copay cards. We do not offer printable Buphenyl manufacturer coupons, Buphenyl discounts, rebates, Buphenyl savings cards, trial offers, or free samples. We are a service provider that helps eligible individuals access patient assistance programs. Our service cost is $49 a month per medication, so you will likely save more on your Buphenyl medication with NiceRx.

Can NiceRx help me get Buphenyl cheaper if I have insurance?

NiceRx may be able to help you access Buphenyl patient assistance if:

  • You have a high copay or coinsurance responsibility for Buphenyl
  • Your insurance company will not pay for your Buphenyl prescription
  • You do not have insurance

Complete your enrollment application online to find out more.

How much does Buphenyl cost without insurance?

Buphenyl prices without insurance will vary by retailer. As a guide, Buphenyl oral powder for reconstitution (0.94 g/g) will typically cost around $14,360 for 250 grams.

How much does Buphenyl cost with insurance?

Your individual healthcare plan will determine the copay of Buphenyl with insurance. To find out what you will need to pay, contact your pharmacist or insurance provider. They will be able to calculate your copay with your current insurance.

What is Buphenyl?

Buphenyl (sodium phenylbutyrate) is an FDA (U.S. Food and Drug Administration) approved medication. It decreases elevated plasma ammonia glutamine levels and is used to treat urea cycle disorders in people who lack certain liver enzymes needed to properly eliminate waste substances from the body. High ammonia levels in the body can cause brain damage and sometimes death

Buphenyl is only used to treat high blood levels of ammonia in patients with carbamylphosphate synthetase (CPS), ornithine transcarbamylase (OTC), and argininosuccinic acid synthetase (AS) deficiencies.

Buphenyl should not be used to manage acute hyperammonemia, which is a medical emergency.

What doses of Buphenyl are available?

Buphenyl is available in tablet form, in the following doses: 500 mg, and powder form in the following doses: 940mg/gram.

Always speak with a healthcare professional for medical advice about any changes to your dose so they can monitor and evaluate your condition.

Buphenyl active ingredients

The active ingredient sodium phenylbutyrate is a prodrug that is metabolized to phenylacetate which conjugates with glutamine to form phenylacetylglutamine, a nitrogen waste product that is excreted renally.

Buphenyl side effects

The most common side effects of Buphenyl in clinical trials include:

  • Loss of appetite
  • Headache
  • Unusual or unpleasant taste in your mouth
  • Amenorrhea (irregular menstrual cycles)
  • Decreased appetite
  • Body odor

In rare instances, Buphenyl can cause more serious adverse effects. These can include:

  • Severe drowsiness
  • Confusion
  • Swelling, rapid weight gain
  • Feeling light-headed
  • Short of breath
  • Increased heart rate
  • Metabolic acidosis – rapid breathing, muscle twitching
  • Hypoalbuminemia, anemia, alkalosis, hyperchloremia, hypophosphatemia, increased alkaline phosphatase, increased liver transaminases, leukopenia, leukocytosis

Seek emergency medical attention if you notice any signs of ammonia build-up, including mood or behavior changes, memory loss, thinking problems, muscle twitching, back and forth movement of the eyes, vomiting, increasing weakness, slurred speech, seizure (convulsions), and fainting.

Your doctor will assess the benefits of using Buphenyl against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Buphenyl to the FDA. Visit, or call 1-800-FDA-1088.

Buphenyl drug interactions

Buphenyl can interact with other medications. These include:

  • Divalproex
  • Haloperidol
  • Valproic acid

This list is not exhaustive and other prescription drugs may interact with Buphenyl. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Buphenyl contraindications

You should not use Buphenyl if you:

  • Are allergic to the active ingredient sodium phenylbutyrate
  • Have had an allergic reaction to any of the other ingredients in Buphenyl

Talk to your doctor before using Buphenyl if you:

  • Are taking any of the medications that could interact with Buphenyl
  • Have congestive heart failure
  • Have high blood pressure
  • Have severe kidney disease
  • Have swelling or fluid retention (edema)
  • Have epilepsy or other seizure disorder
  • Weigh less than 44 pounds
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed

Buphenyl generic

Buphenyl is the trademark brand name for sodium phenylbutyrate. A generic version of sodium phenylbutyrate is available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Buphenyl savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.