Crinone Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Crinone cost savings if eligible

With our assistance, you could access the Crinone patient assistance program and obtain your medication for free. We only charge a flat monthly fee of $49 per medication for our services.

StrengthAvg. monthly price at
a US pharmacy
NiceRx monthly
Monthly savings
with NiceRx
1.125gm of 4%$110.00$49.00$61.00
1.125gm of 8%$180.00$49.00$131.00

Am I eligible for Crinone patient assistance?

We review each Crinone enrollment application individually to determine if you are eligible. Each assistance program has its own eligibility criteria and the factors considered by most programs are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Crinone patient assistance program?

Our process makes it as easy as possible to apply for the Crinone patient assistance program. Begin by completing the enrollment application form on our website. Tell us about any medications that you are taking, including Crinone, your healthcare provider, your insurance plan, and your household income. This information is required by the pharmaceutical manufacturers who will supply the medication, so it is important to make sure this information is accurate and up to date.

We will review the information that you have provided to determine whether you are eligible for patient assistance. If we can pre-qualify you for assistance, NiceRx will handle the full enrollment process on your behalf. If you are approved by the pharmaceutical company, you will typically start receiving your medication in 6 – 8 weeks.

Is NiceRx a Crinone coupons provider?

NiceRx is not a Crinone coupon, Crinone discount card, or Crinone copay card provider. We do not offer Crinone manufacturer coupons, Crinone discounts, rebates, Crinone savings cards, trial offers, or free Crinone samples. We are a service provider that helps eligible individuals access their medication directly from the U.S. pharmaceutical company.

Can NiceRx help me if I have insurance?

NiceRx may be able to help you if:

  • You have a high copay or coinsurance responsibility for Crinone
  • Your insurance company will not pay for your Crinone prescription
  • Your healthcare plan does not cover your medication
  • You do not have insurance

Please apply online to find out if we can help you.

How much does Crinone cost without insurance?

Without insurance, Crinone costs will vary depending on where you buy the medication as prices will vary by retailer. As a guide, Crinone vaginal gel 4% will cost around $120 for 6.75 grams.

How much does Crinone cost with insurance?

The copay for Crinone will depend on the terms of your healthcare plan. Your healthcare provider or pharmacist will be able to calculate your copay with your current insurance. Contact them to find out more.

What is Crinone?

Crinone (progesterone gel) is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Merck Global. Crinone is used to treat infertility in women who do not make enough of the hormone progesterone, which is needed to maintain pregnancy. Progesterone is also needed to keep menstrual periods and ovulation regular and is used to restore the menstrual cycles in women whose cycles have stopped.

Crinone 8% is indicated for progesterone supplementation or replacement as part of an assisted reproductive technology (“ART”) treatment for infertile women with progesterone deficiency. Crinone 4% is indicated for the treatment of secondary amenorrhea. Crinone 8% is indicated for use in women who have failed to respond to treatment with Crinone 4%.

Crinone is also used to prevent overgrowth in the lining of the uterus in postmenopausal women who are receiving estrogen hormone replacement therapy.

What doses of Crinone are available?

Crinone is available as a vaginal gel in the following doses: 4% gel (45 mg), 8% gel (90 mg).

Crinone gel should not be used with other local intravaginal therapy. If other local intravaginal therapy is to be used, there should be at least a 6-hour period before or after Crinone. Crinone gel should be inserted while you are lying on your back with your knees bent. You do not have to remain lying down after inserting the medication.

Please read the patient information and always speak with a healthcare professional for medical advice or about any changes to your dose so they can monitor and evaluate your condition.

Crinone active ingredients

The active ingredient of Crinone is progesterone. It belongs to a class of drugs called progestins.

Crinone side effects

The most common side effects of Crinone in clinical trials include:

  • Dizziness, confusion, drowsiness, fatigue
  • Headache, mood swings, feeling anxious
  • Abdominal pain, nausea, diarrhea, constipation
  • Bloating, swelling in your hands or feet
  • Breast pain, swelling, or tenderness
  • Cramps, joint pain, perineal pain
  • Vaginal discharge, genital itching, or burning

In rare instances, Crinone can cause more serious side effects. These can include:

  • Risk of blood clots, heart attack, stroke, or breast cancer
  • Unusual vaginal bleeding
  • Pain or burning when you urinate
  • Symptoms of depression
  • Severe headache or pain behind your eyes
  • Symptoms of a heart attack – chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating
  • Liver problems – upper stomach pain, loss of appetite, dark urine, clay-colored stools, yellowing of the skin or eyes
  • Signs of a stroke – sudden numb feeling or weakness, especially down one side of the body, sudden severe headache, slurred speech, problems with speech or balance
  • Signs of a blood clot in the lung – chest pain, cough, wheezing, shortness of breath

Your doctor will assess the benefits of using Crinone against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Crinone to the FDA. Visit, or call 1-800-FDA-1088.

Crinone drug interactions

Crinone can interact with other medications. These include:

  • Anticonvulsants – carbamazepine, phenobarbital, phenytoin
  • Opioids – morphine
  • Antibiotics – clarithromycin, erythromycin
  • Antifungals – ketoconazole, itraconazole

This list is not exhaustive and other prescription drugs may interact with Crinone.

Crinone contraindications

You should not use Crinone if you:

  • Are allergic to the active ingredient progesterone
  • Have had an allergic reaction to any of the other ingredients in Crinone
  • Have a history of stroke, blood clot, or circulation problems
  • Have breast or uterine cancer
  • Have abnormal vaginal bleeding
  • Have liver disease
  • Have any type of food allergy
  • Have recently had a tubal pregnancy or an incomplete or “missed” abortion
  • Are pregnant or are planning to become pregnant – use effective contraception to prevent pregnancy

Talk to your doctor before using Crinone if you:

  • Are taking any of the medications that could interact with Crinone
  • Have high blood pressure, heart disease, congestive heart failure
  • Suffer from migraines
  • Have asthma
  • Have kidney disease
  • Have epilepsy
  • Have a history of depression
  • Have risk factors for coronary artery disease
  • Are breastfeeding or are planning to breastfeed – progesterone vaginal can pass into breast milk and may harm a nursing baby

Crinone generic

Crinone is the trademark brand name for progesterone manufactured by Merck Global. A generic version of progesterone is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Crinone savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.