Daraprim Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Daraprim cost savings if eligible

The Daraprim patient assistance program can provide your medication for free. We simply charge $49 a month per medication to cover the cost of our services. With NiceRx, you will only pay $49 to obtain your Daraprim, regardless of the retail price.

StrengthAvg. monthly price at
a US pharmacy
NiceRx monthly
Monthly savings
with NiceRx
25mg 4 tablets$3,000.00$49.00$2,951.00

Am I eligible for the Daraprim patient assistance program?

To find out if you are eligible for Daraprim assistance you can apply online using our enrollment application. Each pharmaceutical company sets its eligibility criteria, and we will review your application individually to determine if you may be eligible. The three main factors to consider are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Daraprim patient assistance program?

Our application process aims to make it as easy as possible to apply for the Daraprim patient assistance program. The first step is to complete our online enrollment application. We will ask you for details about your healthcare provider, your insurance plan, and your household income as this information is required by the pharmaceutical companies. We may be able to help you apply for other patient assistance programs too, so be sure to tell us about any medications you are taking as well as Daraprim.

NiceRx will review your application and determine whether you may be eligible for Daraprim assistance. If so, we will handle the full enrollment process for you and prepare all required documents for your healthcare provider to sign. Once you are successfully enrolled in the Daraprim patient assistance program, we will help you manage your prescription refills by requesting refills on your behalf throughout your enrollment period. At the end of your enrollment period we will contact you for updated information and seek to re-enroll you so you can continue to access affordable Daraprim.

Is NiceRx a Daraprim coupons provider?

NiceRx is a service provider that helps eligible individuals access the Daraprim patient assistance program. We do not offer trial offers or free Daraprim samples. When obtaining your medication through NiceRx, you will only pay $49 a month per medication. This will likely save you more money than if you were to use Daraprim coupons, discount cards, or Daraprim copay cards.

Can NiceRx help me get Daraprim if I have insurance?

NiceRx may be able to help you if your insurance company will not pay for your Daraprim medication. We may also be able to help if you have a high copay or coinsurance responsibility. Whether you have insurance or not, apply online using our enrollment application to find out more.

How much is Daraprim with insurance?

The cost of Daraprim will vary by the terms of your healthcare plan. To find out what you might need to pay for Daraprim with insurance, your insurance provider or pharmacist will be able to help you calculate the copay costs with your current insurance.

How much does Daraprim cost without insurance?

Daraprim prices without insurance will vary depending on the pharmacy you visit. Prices will also vary by retailer. As a guide, Daraprim 25 mg tablets typically cost $23,500 for 30 tablets.

What is Daraprim?

Daraprim contains the prescription medicine pyrimethamine. Pyrimethamine is classed as an antiparasite medicine, used to stop parasites from growing and multiplying in the body.

Daraprim is used to treat certain types of malaria in adults and children. Daraprim is not the preferred choice of medicine to prevent malaria when traveling however, as there is substantial resistance to pyrimethamine worldwide. Daraprim should be used together with other faster-acting anti-malaria medicine such as chloroquine or quinine to treat malaria.

Toxoplasmosis, an infection caused by the Toxoplasma parasite is also treated using Daraprim, in combination with other medicines known as sulfonamides.

Daraprim active ingredients

Pyrimethamine, the active ingredient in Daraprim, blocks the reproduction of the parasite once it is in the hosts’ bloodstream. It does this by interfering with the production of a chemical called tetrahydrofolic acid from dihydrofolate. Tetrahydrofolic acid is vital for DNA production for the parasite. Without this, the parasite is unable to survive.

The effect of pyrimethamine against Toxoplasmosis is far greater when used in combination with sulfonamides.

Daraprim side effects

The most common side effects caused by Daraprim include:

  • Loss of appetite
  • Vomiting

In rare instances, Daraprim can cause more serious side effects. These can include:

  • Irregular heart rhythm
  • Blood in your urine
  • Lack of folate – feeling tired or sick, stomach upset, mood swings, mouth ulcers, loss of appetite
  • Swollen tongue, sore throat
  • Skin rash
  • Pale skin, easily bruised, purple spots under the skin
  • Cold or flu symptoms, cough, fever, difficulty breathing

Your doctor will assess the benefits of using Daraprim against your risk of side effects.

Daraprim drug interactions

Daraprim can interact with other medications. These include:

  • Methotrexate
  • Phenytoin or lamotrigine, used to treat seizures
  • Sulfa drugs such as sulfamethoxazole, sulfadiazine, or sulfasalazine
  • Aurothiglucose or auranofin used to treat rheumatoid arthritis
  • Deferiprone, used to remove excess iron after treatment for thalassemia
  • Gold sodium thiomalate

This list is not exhaustive and other drugs may interact with Daraprim.

Daraprim warning and precautions

You should not use Daraprim if you:

  • Are allergic to the active ingredient pyrimethamine
  • Are allergic to any of the other ingredients in Daraprim
  • Have megaloblastic anemia caused by a lack of folate

Talk to your doctor before using Daraprim if you:

  • Are taking any of the medications that could interact with Daraprim
  • Suffer from seizures, especially if you are taking phenytoin
  • Have liver disease
  • Have kidney disease
  • Suffer from alcoholism
  • If you are malnourished
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed

Related medications

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.