Defitelio Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Defitelio cost savings if eligible

If you are eligible for the Defitelio patient assistance program you can receive your medication for free. Our monthly service fee of $49 per medication covers the cost of our services in applying for the program and requesting your ongoing refills on your behalf. If you obtain your Defitelio through NiceRx, you will only pay $49 a month regardless of the retail price of your medication.

Am I eligible for the Defitelio patient assistance program?

You could receive your Defitelio without paying the full retail price if you meet the eligibility criteria for assistance. The eligibility requirements are set by the pharmaceutical companies that are providing assistance programs. At NiceRx, we review each application individually, although the main factors considered by most programs are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for Defitelio patient assistance?

We do everything that we can to take the hassle and stress out of applying for patient assistance programs. Simply start by filling in our enrollment application. We will ask for details about your healthcare provider, your insurance, and your household income. This information is required by the pharmaceutical companies you are applying to for assistance. We may also be able to help you access patient assistance for other medications that you have been prescribed, so be sure to tell us about any medications you are taking as well as Defitelio.

NiceRx will review the information you have provided, and if we determine that you may be eligible for assistance, we will seek to enroll you in the Defitelio patient assistance program. We will handle the enrollment process for you by working with your healthcare provider and preparing all the required paperwork for your doctor to sign. We will also request your Defitelio medication refills on your behalf for up to 1 year once you are enrolled in the program.

Is NiceRx a Defitelio coupon provider?

At NiceRx, we help eligible individuals access the Defitelio patient assistance program. This means that we are not a Defitelio coupon, a Defitelio discount card, or a Defitelio copay card provider. We do not offer any medication trial offers, or free Defitelio samples.

Can NiceRx help me get Defitelio cheaper if I have insurance?

We may be able to help you if you have insurance, including if your insurance company will not pay for your Defitelio medication, or if you have a high copay or coinsurance responsibility. We may even be able to assist if you do not have insurance. Please fill in our enrollment application to find out more.

How much does Defitelio cost without insurance?

Defitelio costs without insurance will vary depending on how much you buy and the retailer you buy it from. As a guide, Defitelio intravenous solution (80 mg/mL) will typically cost around $10,200 for 25 milliliters. If you obtain your medication through NiceRx, you will pay a flat monthly rate of $49 per medication regardless of its retail price.

How much does Defitelio cost with insurance?

The copay of Defitelio will vary in line with the specific terms of your healthcare plan. For further details about what you may need to pay, your insurance provider or pharmacist will be able to calculate the copay costs with your current insurance.

What is Defitelio?

Defitelio is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Jazz Pharmaceuticals. Defitelio is indicated for the treatment of adult and pediatric patients with hepatic veno-occlusive disease (hepatic VOD), also known as sinusoidal obstruction syndrome (SOS), with renal or pulmonary dysfunction following hematopoietic stem-cell transplantation (HSCT).

What doses of Defitelio are available?

Defitelio is available in injection form, in the following doses: 200 mg/2.5 mL (80 mg/mL) in a single-patient-use vial.

Defitelio is given as a 2-hour intravenous infusion every 6 hours. Treat for a minimum of 21 days. If after 21 days signs and symptoms of VOD have not resolved, continue until resolution.

Please see the full prescribing information and always speak with a healthcare professional about any changes to your dose so they can monitor and evaluate your condition.

Defitelio active ingredients

Defitelio contains defibrotide sodium as the active ingredient. Its mechanism of action is to increase the breakdown of clots in the blood, and may also protect the endothelial cells that line blood vessels.

Defitelio side effects

The most common side effects of Defitelio in clinical trials (incidence ≥10%) include:

  • Hypotension (low blood pressure)
  • Diarrhea, vomiting, nausea
  • Epistaxis

In rare instances, Defitelio can cause more serious side effects. These can include:

  • Hemorrhage – discontinue treatment if significant bleeding occurs
  • Hypersensitivity reactions including anaphylaxis

Your doctor will assess the benefits of using Defitelio against your risk of adverse events. Patients are encouraged to report negative side effects or adverse reactions of Defitelio to the FDA. Visit, or call 1-800-FDA-1088.

Defitelio drug interactions

Defitelio can interact with other medications. These include:

  • Antithrombotic, fibrinolytic drugs – warfarin, heparin

This list is not exhaustive and other prescription drugs may interact with Defitelio.

Defitelio contraindications

You should not use Defitelio if you:

  • Are allergic to the active ingredient defibrotide sodium
  • Have had an allergic reaction to any of the other excipients in Defitelio
  • Are using systemic anticoagulant or fibrinolytic therapy
  • Are pregnant or are planning to become pregnant

Talk to your doctor before using Defitelio if you:

  • Are taking any of the medications that could interact with Defitelio
  • Are breastfeeding or are planning to breastfeed

Defitelio generic

Defitelio is the trademark brand name for defibrotide sodium manufactured by Jazz Pharmaceuticals. A generic version of defibrotide sodium is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Defitelio savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.