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Duopa Patient assistance program

Is your Duopa medication too expensive? Start receiving your medication for only $49 per month.*

Complete a free online enrollment application to find out if you’re eligible to pay only $49 per month for your Duopa medication with our help.

Get started today
  • Secure: Your personal and medical information is safe with us
  • Convenient: We manage the whole process and we’re here to assist you
  • Ongoing refills: We request your medication refills on your behalf
  • Secure: Your personal and medical information is safe with us
  • Convenient: We manage the whole process and we’re here to assist you
  • Ongoing refills: We request your medication refills on your behalf

NiceRx works with your healthcare provider to help you access affordable medications directly from U.S. pharmaceutical companies.

An introduction to NiceRx

Play video (01:52)
  • An introduction to NiceRx
    (01:52)
  • Next steps after qualifying
    (00:38)
  • Uploading documents and billing
    (00:50)
  • SSN & billing information
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  • Medication delivery time
    (00:41)

How it works

  • Apply Online

    Get started by filling out the online enrollment application to find out if you are eligible.

  • Qualification

    NiceRx verifies your eligibility for medication assistance and notifies you if you are qualified. The pharmaceutical company provides your medication for free and you only pay our service fee.

  • Upload Documents

    You may be required to submit further information and documents required by the pharmaceutical company which can be securely uploaded online.

  • Application Created

    Your application is created and sent to your doctor for signature. At this stage, you will be billed $49 and will not be billed again until you receive your first medication delivery.

  • Receive Medication

    Your application is sent to the pharmaceutical company. You will be billed again once you receive your medication. We handle the entire ordering process including requesting ongoing refills.

Medically reviewed by  Jamie Winn, PharmD

Your monthly Duopa cost savings if eligible

With our assistance, you could access the Duopa patient assistance program and obtain your medication for free. We only charge a flat monthly fee of $49 per medication for our services.

Am I eligible for Duopa patient assistance?

We review each Duopa enrollment application individually to determine if you are eligible. Each assistance program has its own eligibility criteria and the factors considered by most programs are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Duopa patient assistance program?

Our process makes it as easy as possible to apply for the Duopa patient assistance program. Begin by completing the enrollment application form on our website. Tell us about any medications that you are taking, including Duopa, your healthcare provider, your insurance plan, and your household income. This information is required by the pharmaceutical manufacturers who will supply the medication, so it is important to make sure this information is accurate and up to date.

We will review the information that you have provided to determine whether you are eligible for patient assistance. If we can pre-qualify you for assistance, NiceRx will handle the full enrollment process on your behalf. If you are approved by the pharmaceutical company, you will typically start receiving your medication in 6 – 8 weeks.

Is NiceRx a Duopa coupon provider?

NiceRx is not a Duopa coupon, Duopa discount card, or Duopa copay card provider. We do not offer Duopa manufacturer coupons, Duopa discounts, rebates, Duopa savings cards, trial offers, or free Duopa samples. We are a service provider that helps eligible individuals access their medication directly from the U.S. pharmaceutical company.

Can NiceRx help me get Duopa cheaper if I have insurance?

NiceRx may be able to help you if:

  • You have a high copay or coinsurance responsibility for Duopa
  • Your insurance company will not pay for your Duopa prescription
  • Your healthcare plan does not cover your medication
  • You do not have insurance

Please apply online to find out if we can help you.

How much does Duopa cost without insurance?

Without insurance, Duopa costs will vary depending on where you buy the medication as prices will vary by retailer. As a guide, Duopa enteral suspension (4.63 mg-20 mg/mL) will cost around $1,550 for 700 milliliters.

How much does Duopa cost with insurance?

The copay for Duopa will depend on the terms of your healthcare plan. Your healthcare provider or pharmacist will be able to calculate your copay with your current insurance. Contact them to find out more.

What is Duopa?

Duopa is an FDA (U.S. Food and Drug Administration) approved medication manufactured by AbbVie Inc. It is a combination of carbidopa (an aromatic amino acid decarboxylation inhibitor) and levodopa (an aromatic amino acid) indicated for the treatment of motor fluctuations in patients with advanced Parkinson’s disease.

What doses of Duopa are available?

Duopa is available in enteral suspension form, in the following doses: 4.63 mg carbidopa and 20 mg levodopa per mL.

Before starting Duopa, convert from all forms of levodopa to oral immediate-release carbidopa-levodopa tablets. Administer Duopa into the jejunum through a percutaneous endoscopic gastrostomy with a jejunal tube (PEG-J) with the CADD-Legacy 1400 portable infusion pump.

Duopa is taken over a 16 hour infusion period. The daily dose is based on patient titration and is composed of a morning dose, a continuous dose, and extra doses. The maximum recommended daily dose of Duopa is 2000 mg of the levodopa component (i.e., one cassette per day) over 16 hours. At the end of the daily 16 hour infusion, you will disconnect the pump from the PEG-J and take the night-time dose of oral immediate-release carbidopa-levodopa tablets.

The extra dose function can be used to manage acute “Off” symptoms that are not controlled by the morning dose and the continuous dose administered over 16 hours. The extra dose function is set at 1 mL when starting Duopa. The extra dose frequency is limited to one extra dose every 2 hours. Administration of frequent extra doses may cause or worsen dyskinesias.

Duopa is used at room temperature. Take one Duopa cassette out of the refrigerator and out of the carton 20 minutes before use. You may not receive the right amount of medication if the product is not given at room temperature.

Please read the full prescribing information and medication guide for the instructions for use and always speak with a healthcare professional about any changes to your dose so they can monitor and evaluate your condition.

Duopa active ingredients

The active ingredient of Duopa is carbidopa/levodopa

Duopa side effects

The most common side effects of Duopa in clinical trials include:

  • Complication of device insertion
  • Nausea
  • Depression
  • Peripheral edema
  • Hypertension
  • Upper respiratory tract infection
  • Oropharyngeal pain
  • Incision site erythema

In rare instances, Duopa can cause more serious side effects. These can include:

  • Blockage of your stomach or intestines (bezoar) stopping movement through intestines (ileus)
  • Drainage, redness, swelling, pain, feeling of warmth around the small hole in your stomach wall (stoma)
  • Bleeding from stomach ulcers or your intestines
  • Inflammation of your pancreas (pancreatitis)
  • Infection in your lungs (pneumonia)
  • Air or gas in your abdominal cavity
  • Skin infection around the intestinal tube, a pocket of infection (abscess), or infection in your blood (sepsis) or abdominal cavity may occur after surgery
  • Somnolence, sleepiness
  • Orthostatic hypotension
  • Hallucinations, psychosis, confusion
  • Compulsive behaviors
  • Depression and thoughts of suicide
  • Peripheral neuropathy
  • Myocardial infarction and arrhythmia
  • Increased blood pressure, a fast or irregular heartbeat, or chest pain
  • Glaucoma
  • Upper abdominal pain, duodenal ulcer, duodenal ulcer hemorrhage, erosive duodenitis, erosive gastritis, gastrointestinal hemorrhage, intussusception, peritonitis, post-operative abscess, and small intestine ulcer
  • Stomach pain, nausea, vomiting, ongoing constipation, fever, bloody or tarry stools

Your doctor will assess the benefits of using Duopa against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Duopa to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Duopa drug interactions

Duopa can interact with other medications. These include:

  • Nonselective monoamine oxidase (MAO) inhibitors – isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine
  • Antihypertensive drugs
  • Dopamine D2 receptor antagonists, isoniazid, iron salts, and a high-protein diet may reduce the effectiveness of Duopa

This list is not exhaustive and other prescription drugs may interact with Duopa. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Duopa contraindications

You should not use Duopa if you:

  • Are allergic to the active ingredient carbidopa/levodopa
  • Are allergic to any of the other ingredients in Duopa

Talk to your doctor about your medical condition before using Duopa if you:

  • Are taking any of the medications that could interact with Duopa
  • Have a stomach ulcer or have had stomach surgery
  • Have low blood pressure
  • Have heart disease, high blood pressure, or have had a heart attack
  • Have problems falling asleep suddenly during the day
  • Suffer from depression or mental illness
  • Have glaucoma
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed

Duopa generic

Duopa is the trademark brand name for carbidopa/levodopa manufactured by AbbVie Inc. North Chicago, A generic version of carbidopa/levodopa is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Duopa savings through NiceRx.

*Qualifying persons may obtain medications directly from patient assistance programs without any out-of-pocket cost (or for less than $49 per medication). However, our monthly flat rate of just $49 per medication spares you the hassle of tracking down the different programs and filling out all the required paperwork for each program.

Enrollees enjoy a full-service solution, as NiceRx assists them and their physicians with the entire process. We prepare all required documents for the physician to sign, help enrollees manage all prescription refills, monitor eligibility criteria, and maintain enrollment.

**If you do not receive medications because you were determined to be ineligible for the prescription assistance by the applicable pharmaceutical companies and you have a letter of denial, we will refund any fees you paid toward medications for which you did not qualify to receive prescription assistance (“Refund”).

To receive a refund, you must send the letter of denial to us by fax to 888-517-7444, or by e-mail to [email protected] within 30 days of your receipt of such letter. The Refund is your sole and exclusive remedy for any fees you may wish to dispute.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.