Duopa Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Is NiceRx a Duopa coupon provider?

NiceRx is not a Duopa coupon, Duopa discount card, or Duopa copay card provider. We do not offer Duopa manufacturer coupons, Duopa discounts, rebates, Duopa savings cards, trial offers, or free Duopa samples. We are a service provider that helps eligible individuals access their medication directly from the U.S. pharmaceutical company.

Duopa patient assistance program

Patient assistance programs are typically sponsored by pharmaceutical companies and provide free or discounted medications to individuals with low income who are uninsured or under-insured and meet the eligibility criteria that vary by program. There are currently no known patient assistance programs for this medication.

How much does Duopa cost without insurance?

Without insurance, Duopa costs will vary depending on where you buy the medication as prices will vary by retailer. As a guide, Duopa enteral suspension (4.63 mg-20 mg/mL) will cost around $1,550 for 700 milliliters.

How much does Duopa cost with insurance?

The copay for Duopa will depend on the terms of your healthcare plan. Your healthcare provider or pharmacist will be able to calculate your copay with your current insurance. Contact them to find out more.

What is Duopa?

Duopa is an FDA (U.S. Food and Drug Administration) approved medication manufactured by AbbVie Inc. It is a combination of carbidopa (an aromatic amino acid decarboxylation inhibitor) and levodopa (an aromatic amino acid) indicated for the treatment of motor fluctuations in patients with advanced Parkinson’s disease.

What doses of Duopa are available?

Duopa is available in enteral suspension form, in the following doses: 4.63 mg carbidopa and 20 mg levodopa per mL.

Before starting Duopa, convert from all forms of levodopa to oral immediate-release carbidopa-levodopa tablets. Administer Duopa into the jejunum through a percutaneous endoscopic gastrostomy with a jejunal tube (PEG-J) with the CADD-Legacy 1400 portable infusion pump.

Duopa is taken over a 16 hour infusion period. The daily dose is based on patient titration and is composed of a morning dose, a continuous dose, and extra doses. The maximum recommended daily dose of Duopa is 2000 mg of the levodopa component (i.e., one cassette per day) over 16 hours. At the end of the daily 16 hour infusion, you will disconnect the pump from the PEG-J and take the night-time dose of oral immediate-release carbidopa-levodopa tablets.

The extra dose function can be used to manage acute “Off” symptoms that are not controlled by the morning dose and the continuous dose administered over 16 hours. The extra dose function is set at 1 mL when starting Duopa. The extra dose frequency is limited to one extra dose every 2 hours. Administration of frequent extra doses may cause or worsen dyskinesias.

Duopa is used at room temperature. Take one Duopa cassette out of the refrigerator and out of the carton 20 minutes before use. You may not receive the right amount of medication if the product is not given at room temperature.

Please read the full prescribing information and medication guide for the instructions for use and always speak with a healthcare professional about any changes to your dose so they can monitor and evaluate your condition.

Duopa active ingredients

The active ingredient of Duopa is carbidopa/levodopa

Duopa side effects

The most common side effects of Duopa in clinical trials include:

  • Complication of device insertion
  • Nausea
  • Depression
  • Peripheral edema
  • Hypertension
  • Upper respiratory tract infection
  • Oropharyngeal pain
  • Incision site erythema

In rare instances, Duopa can cause more serious side effects. These can include:

  • Blockage of your stomach or intestines (bezoar) stopping movement through intestines (ileus)
  • Drainage, redness, swelling, pain, feeling of warmth around the small hole in your stomach wall (stoma)
  • Bleeding from stomach ulcers or your intestines
  • Inflammation of your pancreas (pancreatitis)
  • Infection in your lungs (pneumonia)
  • Air or gas in your abdominal cavity
  • Skin infection around the intestinal tube, a pocket of infection (abscess), or infection in your blood (sepsis) or abdominal cavity may occur after surgery
  • Somnolence, sleepiness
  • Orthostatic hypotension
  • Hallucinations, psychosis, confusion
  • Compulsive behaviors
  • Depression and thoughts of suicide
  • Peripheral neuropathy
  • Myocardial infarction and arrhythmia
  • Increased blood pressure, a fast or irregular heartbeat, or chest pain
  • Glaucoma
  • Upper abdominal pain, duodenal ulcer, duodenal ulcer hemorrhage, erosive duodenitis, erosive gastritis, gastrointestinal hemorrhage, intussusception, peritonitis, post-operative abscess, and small intestine ulcer
  • Stomach pain, nausea, vomiting, ongoing constipation, fever, bloody or tarry stools

Your doctor will assess the benefits of using Duopa against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Duopa to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Duopa drug interactions

Duopa can interact with other medications. These include:

  • Nonselective monoamine oxidase (MAO) inhibitors – isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine
  • Antihypertensive drugs
  • Dopamine D2 receptor antagonists, isoniazid, iron salts, and a high-protein diet may reduce the effectiveness of Duopa

This list is not exhaustive and other prescription drugs may interact with Duopa. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Duopa contraindications

You should not use Duopa if you:

  • Are allergic to the active ingredient carbidopa/levodopa
  • Are allergic to any of the other ingredients in Duopa

Talk to your doctor about your medical condition before using Duopa if you:

  • Are taking any of the medications that could interact with Duopa
  • Have a stomach ulcer or have had stomach surgery
  • Have low blood pressure
  • Have heart disease, high blood pressure, or have had a heart attack
  • Have problems falling asleep suddenly during the day
  • Suffer from depression or mental illness
  • Have glaucoma
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed

Duopa generic

Duopa is the trademark brand name for carbidopa/levodopa manufactured by AbbVie Inc. North Chicago, A generic version of carbidopa/levodopa is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Duopa savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.