Elestrin Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Elestrin cost savings if eligible

If you are eligible for the Elestrin patient assistance program, the cost of your medication will be free. We only charge $49 per month for each medication, to cover our service fees. You could receive your Elestrin prescription for just $49 a month, regardless of the retail price of your medication.

Am I eligible for the Elestrin patient assistance program?

We will review your application to determine whether you are eligible for the Elestrin patient assistance program. Each program has its own eligibility criteria which is set by the pharmaceutical companies, however the factors considered by most programs are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Elestrin patient assistance program?

We make it as easy as possible to apply for the Elestrin patient assistance program. The first step is to complete our enrollment application. Tell us about any medications you are taking, including Elestrin. We will also ask for details about your healthcare provider, insurance, and your household income. This information is required by the pharmaceutical manufacturers who ship your medication.

If we determine that you may be eligible for Elestrin assistance, we will handle the application process for you. We will work directly with your healthcare provider to prepare your application documents. Once we have received the signed application and supporting documents, we will submit them to the patient assistance program on your behalf. Our service continues once you are enrolled in the Elestrin patient assistance program, and we will automatically request your Elestrin medication refills for up to 1 year.

Is NiceRx an Elestrin coupon provider?

We are a service provider that helps eligible individuals access the Elestrin patient assistance program. That means that we do not offer printable Elestrin manufacturer coupons, Elestrin discounts, or free Elestrin samples. We are not an Elestrin coupon provider or Elestrin discount card. Our service extends to assisting eligible individuals to access the medications they need through patient assistance programs.

Can NiceRx help me get Elestrin cheaper if I have insurance?

We may be able to help you to access Elestrin patient assistance in a variety of circumstances. This includes when your insurance company will not pay for your Elestrin medication or if you have a high copay or coinsurance responsibility. We may also be able to help you if you do not have insurance. Please apply online to find out more.

How much does Elestrin cost without insurance?

Elestrin cost without insurance will vary depending on where you buy it. As a guide, Elestrin transdermal gel (0.52 mg/0.87 g (0.06%)) usually costs $250 for 52 grams. With NiceRx you will pay a flat monthly fee of $49, regardless of the retail price of your medication.

How much does Elestrin cost with insurance?

The copay for Elestrin with insurance depends on the terms of your healthcare plan. To find out how much this is, your healthcare provider or pharmacist will be able to calculate your copay with your current insurance.

What is Elestrin?

Elestrin (estradiol gel) is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Meda Pharmaceutical. It is an estrogen indicated for the treatment of moderate to severe vasomotor symptoms due to menopause. Symptoms of menopause include night sweats, hot flashes, flushes, and vaginal dryness.

Estrogens are hormones normally made by a woman’s ovaries. Ovaries normally stop making estrogens when a woman is between 45 to 55 years old. This drop in estrogen levels causes menopause. If both ovaries are removed during an operation before natural menopause takes place. The sudden drop in estrogen levels causes surgical menopause.

There is an increased risk of endometrial cancer in a woman with a uterus who uses unopposed estrogens. Estrogen-alone therapy should not be used for the prevention of cardiovascular disease or dementia. The Women’s Health Initiative (WHI) estrogen-alone substudy reported increased risks of stroke and deep vein thrombosis (DVT). The WHI Memory Study (WHIMS) estrogen-alone ancillary study of WHI reported an increased risk of probable dementia in postmenopausal women 65 years of age and older.

Estrogen plus progestin therapy should not be used for the prevention of cardiovascular disease or dementia. The WHI estrogen plus progestin substudy reported increased risks of stroke, DVT, pulmonary embolism (PE), and myocardial infarction. The WHI estrogen plus progestin study reported increased risks of invasive breast cancer. The WHIMS estrogen plus progestin ancillary study of WHI reported an increased risk of probable dementia in postmenopausal women 65 years of age and older.

What doses of Elestrin are available?

Elestrin is available in a metered-dose pump form, in the following doses: 0.52 mg of estradiol in 0.87 g of gel per pump actuation.

Patients should be started with the lowest effective dose, which is one pump per day. Prime the pump before using the pump for the first time. The recommended daily dose is one pump actuation to deliver 0.87 g of gel providing 0.52 mg estradiol, or two pump actuations to deliver 1.7 g of gel providing 1.04 mg estradiol to the upper arm. Elestrin is an alcohol-based gel and is potentially flammable. Avoid fire, flame, or smoking until Elestrin has dried

Always speak with your healthcare provider about any changes to your dose so they can monitor and evaluate your condition.

Elestrin active ingredients

Elestrin contains estradiol as the active ingredient.

Elestrin side effects

The most common side effects of Elestrin in clinical trials compared to placebo include:

  • Breast tenderness
  • Breast pain
  • Metrorrhagia, changes in menstrual periods
  • Nasopharyngitis
  • Upper respiratory tract infections
  • Nausea, vomiting
  • Stomach cramps
  • Bloating, fluid retention
  • Weight gain
  • Headache
  • Vaginal itching or discharge
  • Thinning scalp hair
  • Stuffy nose, sneezing, sore throat

In rare instances, Elestrin can cause more serious side effects. These can include:

  • Gallbladder disease
  • Severe hypercalcemia
  • Loss of vision
  • Severe hypertriglyceridemia
  • Cholestatic jaundice
  • Heart attack, stroke, blood clots
  • Dementia
  • Breast cancer
  • Cancer of the lining of the uterus, cancer of the ovary, enlargement of benign tumors of the uterus (fibroids)
  • High blood pressure
  • High blood sugar
  • Chest pain
  • Liver problems
  • New breast lumps
  • Unusual vaginal bleeding
  • Changes in vision or speech
  • Sudden new severe headaches

Your doctor will assess the benefits of using Elestrin against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Elestrin to the FDA. Visit, or call 1-800-FDA-1088.

Elestrin drug interactions

Elestrin can interact with other medications.

  • Inducers and/or inhibitors of CYP3A4
  • Estradiol absorption was increased when sunscreen was applied 10 minutes before Elestrin application. Sunscreen should not be applied to the same site until at least 25 minutes after the application of Elestrin

This list is not exhaustive and other prescription drugs may interact with Elestrin. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Elestrin contraindications

You should not use Elestrin if you:

  • Are allergic to the active ingredient estradiol
  • Are allergic to any of the other ingredients in Elestrin
  • Have undiagnosed abnormal genital bleeding
  • Have known, suspected, or a history of breast cancer
  • Have known or suspected estrogen-dependent neoplasia
  • Have active DVT, PE, or history of these conditions
  • Have active arterial thromboembolic disease
  • Have known liver impairment or disease
  • Have known protein C, protein S, antithrombin deficiency, or other known thrombophilic disorders
  • Are pregnant or are planning to become pregnant

Talk to your doctor before using Elestrin if you:

  • Are taking any of the medications that could interact with Elestrin
  • Are a woman over 65 years of age – increased risk of probable dementia
  • Have unusual vaginal bleeding
  • Have heart disease, asthma, epilepsy, or other seizure disorder
  • Have hereditary angioedema
  • Have endometriosis
  • Have a thyroid disorder such as hypothyroidism
  • Have high levels of calcium in your blood (hypercalcemia)
  • Suffer from migraines
  • Have gallbladder disease
  • Have risk factors for coronary artery disease (such as diabetes, smoking, being overweight, having high blood pressure or high cholesterol, having a family history of coronary artery disease, being older than 40, or if you have had a hysterectomy)
  • Are breastfeeding or are planning to breastfeed

Elestrin generic

Elestrin is the trademark brand name for estradiol manufactured by Meda Pharmaceutical. A generic version of estradiol is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Elestrin savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.