medicationsEnvarsus Xr

Envarsus XR Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Envarsus XR cost savings if eligible

If you are eligible for the Envarsus XR patient assistance program, the cost of your medication will be free. We only charge $49 per month for each medication, to cover our service fees. You could receive your Envarsus XR prescription for just $49 a month, regardless of the retail price of your medication.

Am I eligible for the Envarsus XR patient assistance program?

We will review your application to determine whether you are eligible for the Envarsus XR patient assistance program. Each program has its own eligibility criteria which is set by the pharmaceutical companies, however, the factors considered by most programs are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Envarsus XR patient assistance program?

We make it as easy as possible to apply for the Envarsus XR patient assistance program. The first step is to complete our enrollment application. Tell us about any medications you are taking, including Envarsus XR. We will also ask for details about your healthcare provider, insurance, and your household income. This information is required by the pharmaceutical manufacturers who ship your medication.

If we determine that you may be eligible for Envarsus XR assistance, we will handle the application process for you. We will work directly with your healthcare provider to prepare your application documents. Once we have received the signed application and supporting documents, we will submit them to the patient assistance program on your behalf. Our service continues once you are enrolled in the Envarsus XR patient assistance program, and we will automatically request your Envarsus XR medication refills for up to 1 year.

Is NiceRx an Envarsus XR coupon provider?

We are a service provider that helps eligible individuals access the Envarsus XR patient assistance program. That means that we do not offer printable Envarsus XR manufacturer coupons, Envarsus XR discounts, or free Envarsus XR samples. We are not an Envarsus XR coupon provider or Envarsus XR discount card. Our service extends to assisting eligible individuals to access the medications they need through patient assistance programs.

Can NiceRx help me get Envarsus XR cheaper if I have insurance?

We may be able to help you to access Envarsus XR patient assistance in a variety of circumstances. This includes when your insurance company will not pay for your Envarsus XR medication or if you have a high copay or coinsurance responsibility. We may also be able to help you if you do not have insurance. Please apply online to find out more.

How much does Envarsus XR cost without insurance?

Envarsus XR cost without insurance will vary depending on where you buy it. As a guide, Envarsus XR XR oral tablet, extended-release 0.75 mg usually costs $150 for 30 tablets. With NiceRx you will pay a flat monthly fee of $49, regardless of the retail price of your medication.

How much does Envarsus XR cost with insurance?

The copay for Envarsus XR with insurance depends on the terms of your healthcare plan. To find out how much this is, your healthcare provider or pharmacist will be able to calculate your copay with your current insurance.

What is Envarsus XR?

Envarsus XR is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Veloxis Pharmaceuticals. It is a calcineurin-inhibitor immunosuppressant indicated for:

  • The prophylaxis of organ rejection in de novo kidney transplant patients post-transplant in combination with other immunosuppressants
  • The prophylaxis of organ rejection in kidney transplant recipients converted from tacrolimus immediate-release formulations in combination with other immunosuppressants

There is an increased risk for developing serious infections, lymphoma, and malignancies with Envarsus XR or other immunosuppressants that may lead to hospitalization or death.

What doses of Envarsus XR are available?

Envarsus XR is available in extended-release tablet form, in the following doses: 0.75 mg, 1 mg, 4 mg.

Take Envarsus XR once daily on an empty stomach at the same time of day, preferably in the morning. Avoid eating grapefruit or drinking grapefruit juice or alcohol. African-American patients may need to be titrated to higher dosages to achieve the target tacrolimus concentrations. Patients with severe hepatic impairment may require a lower starting dose. Frequent monitoring of trough concentrations is recommended.

If you miss your dose of Envarsus XR, take it as soon as possible, but no longer than 15 hours after missing your dose. If the time after you miss your dose is more than 15 hours, the missed dose should be skipped and the next dose should be taken the following morning at your normal scheduled time. Do not take 2 doses at the same time.

See the full prescribing information for the complete boxed warning, and read the full medication guide. Always speak with your healthcare provider about any changes to your dose so they can monitor and evaluate your condition.

Envarsus XR active ingredients

Envarsus XR contains tacrolimus as the active ingredient.

Envarsus XR side effects

The most common side effects of Envarsus XR in clinical trials (incidence ≥15%) include:

  • Diarrhea, constipation, headache
  • Anemia
  • Urinary tract infection
  • Diabetes mellitus
  • Peripheral edema
  • Hyperkalemia
  • For kidney transplant patients converting from immediate-release to extended-release tacrolimus, the most common adverse reactions include diarrhea and blood creatinine increased

In rare instances, Envarsus XR can cause more serious side effects. These can include:

  • Progressive multifocal leukoencephalopathy (PML)
  • New-Onset diabetes after transplant
  • Nephrotoxicity – monitor renal function
  • Neurotoxicity – including the risk of posterior reversible encephalopathy syndrome (PRES)
  • Hyperkalemia – monitor serum potassium levels
  • Hypertension (high blood pressure)
  • QT prolongation
  • Pure red cell aplasia

Your doctor will assess the benefits of using Envarsus XR against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Envarsus XR to the FDA. Visit, or call 1-800-FDA-1088.

Envarsus XR drug interactions

Envarsus XR can interact with other medications. These include:

  • Mild or moderate CYP3A inhibitors – erythromycin
  • Calcium channel blockers – verapamil, diltiazem, nifedipine, nicardipine
  • Azole antifungals – clotrimazole, fluconazole, voriconazole
  • Aluminum, magnesium antacids
  • Cyclosporine, sirolimus, temsirolimus, ziprasidone
  • Other drugs that may increase the level of potassium in the blood – amiloride, spironolactone
  • Drugs that weaken the immune system and increase the risk of infection – natalizumab, rituximab
  • St. John’s wort
  • HIV and HCV protease inhibitors – nelfinavir, ritonavir, boceprevir, telaprevir
  • Rifamycins – rifampin, rifabutin
  • Avoid live vaccines

This list is not exhaustive and other prescription drugs may interact with Envarsus XR. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Envarsus XR contraindications

You should not use Envarsus XR if you:

  • Are allergic to the active ingredient tacrolimus
  • Are allergic to any of the other ingredients in Envarsus XR
  • Are pregnant or are planning to become pregnant

Talk to your doctor before using Envarsus XR if you:

  • Are taking any of the medications that could interact with Envarsus XR
  • Are breastfeeding or are planning to breastfeed

Envarsus XR generic

Envarsus XR is the trademark brand name for tacrolimus manufactured by Veloxis Pharmaceuticals. A generic version of tacrolimus is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Envarsus XR savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.