Estrace Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Estrace cost savings if eligible

With our assistance, you could access the  Estrace patient assistance program and obtain your medication for free. We only charge a flat monthly fee of $49 per medication for our services.

Am I eligible for  Estrace patient assistance?

We review each  Estrace enrollment application individually to determine if you are eligible. Each assistance program has its own eligibility criteria and the factors considered by most programs are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the  Estrace patient assistance program?

Our process makes it as easy as possible to apply for the  Estrace patient assistance program. Begin by completing the enrollment application form on our website. Tell us about any medications that you are taking, including  Estrace, your healthcare provider, your insurance plan, and your household income. This information is required by the pharmaceutical manufacturers who will supply the medication, so it is important to make sure this information is accurate and up to date.

We will review the information that you have provided to determine whether you are eligible for patient assistance. If we can pre-qualify you for assistance, NiceRx will handle the full enrollment process on your behalf. If you are approved by the pharmaceutical company, you will typically start receiving your medication in 6 – 8 weeks.

Is NiceRx an  Estrace coupon provider?

NiceRx is not an  Estrace coupon,  Estrace discount card, or  Estrace copay card provider. We do not offer  Estrace manufacturer coupons,  Estrace discounts, rebates,  Estrace savings cards, trial offers, or free  Estrace samples. We are a service provider that helps eligible individuals access their medication directly from the U.S. pharmaceutical company.

Can NiceRx help me get  Estrace cheaper if I have insurance?

NiceRx may be able to help you if:

  • You have a high copay or coinsurance responsibility for  Estrace
  • Your insurance company will not pay for your  Estrace prescription
  • Your healthcare plan does not cover your medication
  • You do not have insurance

Please apply online to find out if we can help you.

How much does  Estrace cost without insurance?

Without insurance,  Estrace costs will vary depending on where you buy the medication as prices will vary by retailer. As a guide,  Estrace oral tablets 0.5 mg will cost around $580 for 100 tablets.

How much does  Estrace cost with insurance?

The copay for  Estrace will depend on the terms of your healthcare plan. Your healthcare provider or pharmacist will be able to calculate your copay with your current insurance. Contact them to find out more.

What is  Estrace?

Estrace is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Teva Pharmaceutical Industries Ltd. Estrace is used to treat the symptoms of menopause such as hot flashes, vaginal changes, the prevention of osteoporosis in menopausal women, and to replace estrogen in women with ovarian failure.

Estrace is not recommended to prevent heart disease, stroke, or dementia.

What doses of  Estrace are available?

Estrace is available in tablet form, in the following doses: 0.5 mg. Estrace is also available as a vaginal cream.

Make sure you have regular physical exams and mammograms and self-examine your breasts for lumps on a monthly basis while using Estrace.

Please read the full patient information and drug information provided and always speak with a healthcare professional for medical advice about any changes to your dose so they can monitor and evaluate your condition.

 Estrace active ingredients

The active ingredient of  Estrace is estradiol.

 Estrace side effects

The most common side effects of  Estrace in clinical trials include:

  • Bloating
  • Breast tenderness, breast pain
  • Headache, back pain
  • Weight gain
  • Nausea, vomiting, diarrhea, stomach cramps
  • Mood changes
  • Sleep problems (insomnia)
  • Thinning scalp hair
  • Vaginal itching or discharge
  • Changes in your menstrual periods
  • Breakthrough bleeding

In rare instances,  Estrace can cause more serious side effects. These can include:

  • Risk of endometrial cancer increases with the use of unopposed estrogens. Adding progestin may reduce the risk of endometrial hyperplasia, a precursor to uterine cancer
  • Increased risk of blood clots, stroke, heart attack, or cancer of the breast, uterus, or ovaries
  • Chest pain or pressure, spreading to your jaw or shoulder, nausea, sweating
  • Sudden numbness or weakness (especially down one side of the body), sudden severe headache, slurred speech
  • Sudden vision loss, sharp chest pain, shortness of breath, coughing up blood, pain or warmth in one or both legs
  • Jaundice (yellowing of the skin or eyes)
  • Memory problems, confusion
  • Abnormal vaginal bleeding, pelvic pain
  • High levels of calcium in your blood

Your doctor will assess the benefits of using  Estrace against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of  Estrace to the FDA. Visit, or call 1-800-FDA-1088.

 Estrace drug interactions

Estrace can interact with other medications. These include:

  • Aromatase inhibitors – anastrozole, exemestane, letrozole
  • Inducers of CYP3A4 such as St. John’s Wort, phenobarbital, carbamazepine, and rifampin
  • Inhibitors of CYP3A4 such as erythromycin, clarithromycin, ketoconazole, itraconazole, ritonavir, and grapefruit juice
  • Patients on thyroid replacement therapy may require higher doses of thyroid hormone

This list is not exhaustive and other prescription drugs may interact with  Estrace. Tell your healthcare provider about all the medicines you take. This includes prescription and nonprescription medicines, vitamins, and herbal supplements.

 Estrace contraindications

You should not use  Estrace if you:

  • Are allergic to the active ingredient estradiol
  • Have had an allergic reaction to any of the other ingredients in  Estrace
  • Have undiagnosed vaginal bleeding
  • Have liver disease
  • Have a bleeding disorder
  • Have ever had a heart attack, a stroke, or a blood clot
  • Have undiagnosed unusual vaginal bleeding
  • Have a history of hormone-related cancer, breast cancer, or cancer of the uterus/cervix, or vagina
  • Are pregnant or are planning to become pregnant

Talk to your doctor before using  Estrace if you:

  • Are taking any of the medications that could interact with  Estrace
  • Have high blood pressure
  • Have diabetes
  • Have high cholesterol
  • Are overweight
  • Smoke
  • Have heart disease
  • Have liver problems, or jaundice caused by pregnancy or taking hormones
  • Have kidney disease
  • Have gallbladder disease
  • Have asthma
  • Suffer from seizures
  • Suffer from migraines
  • Have endometriosis or uterine fibroid tumors
  • Have a family history of angioedema
  • Have porphyria
  • Have a thyroid disorder
  • Have high levels of calcium in your blood
  • Are breastfeeding or are planning to breastfeed – Estrace can slow breast milk production

 Estrace generic

Estrace is the trademark brand name for estradiol manufactured by Teva Pharmaceutical Industries Ltd. A generic version of estradiol is available. Generic drugs are generally cheaper than brand-name drugs, but you can still find  Estrace savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.