Evomela Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Evomela cost savings if eligible

With our assistance, you could access the Evomela patient assistance program and obtain your medication for free. We only charge a flat monthly fee of $49 per medication for our services.

Am I eligible for Evomela patient assistance?

We review each Evomela enrollment application individually to determine if you are eligible. Each assistance program has its own eligibility criteria and the factors considered by most programs are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Evomela patient assistance program?

Our process makes it as easy as possible to apply for the Evomela patient assistance program. Begin by completing the enrollment application form on our website. Tell us about any medications that you are taking, including Evomela, your healthcare provider, your insurance plan, and your household income. This information is required by the pharmaceutical manufacturers who will supply the medication, so it is important to make sure this information is accurate and up to date.

We will review the information that you have provided to determine whether you are eligible for patient assistance. If we can pre-qualify you for assistance, NiceRx will handle the full enrollment process on your behalf. If you are approved by the pharmaceutical company, you will typically start receiving your medication in 6 – 8 weeks.

Is NiceRx an Evomela coupon provider?

NiceRx is not an Evomela coupon, Evomela discount card, or Evomela copay card provider. We do not offer Evomela manufacturer coupons, Evomela discounts, rebates, Evomela savings cards, trial offers, or free Evomela samples. We are a service provider that helps eligible individuals access their medication directly from the U.S. pharmaceutical company.

Can NiceRx help me get Evomela cheaper if I have insurance?

NiceRx may be able to help you if:

  • You have a high copay or coinsurance responsibility for Evomela
  • Your insurance company will not pay for your Evomela prescription
  • Your healthcare plan does not cover your medication
  • You do not have insurance

Please apply online to find out if we can help you.

How much does Evomela cost without insurance?

Without insurance, Evomela costs will vary depending on where you buy the medication as prices will vary by retailer. As a guide, Evomela intravenous powder for injection 50 mg will cost around $1,700 for 1 powder for injection.

How much does Evomela cost with insurance?

The copay for Evomela will depend on the terms of your healthcare plan. Your healthcare provider or pharmacist will be able to calculate your copay with your current insurance. Contact them to find out more.

What is Evomela?

Evomela is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Acrotech Biopharma LLC. Evomela is an alkylating agent indicated for:

  • Use as a high-dose conditioning treatment prior to hematopoietic progenitor (stem) cell transplantation in patients with multiple myeloma
  • The palliative treatment of patients with multiple myeloma for whom oral therapy is not appropriate

What doses of Evomela are available?

Evomela is available in injection form, in the following doses: 50 mg per vial, lyophilized powder in a single-dose vial for reconstitution.

For conditioning treatment, the recommended dose of Evomela is 100 mg/m2 each day administered over 30 minutes by intravenous infusion for 2 consecutive days prior to autologous stem cell transplantation (ASCT).

For palliative treatment, the recommended dose of Evomela is 16 mg/m2 administered as a single intravenous infusion over 15-20 minutes at 2-week intervals for 4 doses, then, after adequate recovery from toxicity, at 4-week intervals.

Do not mix Evomela with other melphalan hydrochloride for injection drug products. See the full prescribing information for the complete boxed warning, and always speak with a healthcare professional about any changes to your dose so they can monitor and evaluate your condition.

Evomela active ingredients

The active ingredient of Evomela is melphalan.

Evomela side effects

The most common side effects of Evomela in clinical trials include:

  • Neutropenia (decreased neutrophil count)
  • Decreased white blood cell count
  • Decreased lymphocyte count
  • Thrombocytopenia (decreased platelet count)
  • Hypokalemia
  • Anemia
  • Fatigue

In rare instances, Evomela can cause more serious side effects. These can include:

  • Gastrointestinal toxicity – nausea, vomiting, diarrhea, or oral mucositis. Provide supportive care using antiemetic and antidiarrheal medications
  • Embryo-fetal toxicity
  • Infertility – may cause ovarian function suppression or testicular suppression
  • Liver problems – symptoms include yellowing of your skin or the whites of your eyes, pain on the right side of your stomach area, severe nausea or vomiting, dark urine
  • Severe bone marrow suppression with resulting infection or bleeding may occur. Controlled trials comparing intravenous (IV) melphalan to oral melphalan have shown more myelosuppression with the IV formulation. Monitor hematologic laboratory parameters
  • Hypersensitivity reactions, including anaphylaxis, have occurred in approximately 2% of patients who received the IV formulation of melphalan. Discontinue treatment for serious hypersensitivity reactions

Your doctor will assess the benefits of using Evomela against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Evomela to the FDA. Visit, or call 1-800-FDA-1088.

Evomela drug interactions

Evomela can interact with other medications.

  • Severe renal impairment has been reported in patients treated with a single dose of intravenous melphalan followed by standard oral doses of cyclosporine
  • When nalidixic acid and IV melphalan are given simultaneously, the incidence of severe hemorrhagic necrotic enterocolitis increases in pediatric patients

This list is not exhaustive and other prescription drugs may interact with Evomela. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Evomela contraindications

You should not use Evomela if you:

  • Have a history of serious allergic reactions to melphalan
  • Are allergic to any of the other ingredients in Evomela
  • Are pregnant or are planning to become pregnant – females of reproductive potential are advised to use effective contraception during treatment and for 6 months after the last dose
  • Are breastfeeding or are planning to breastfeed

Talk to your doctor before using Evomela if you:

  • Are taking any of the medications that could interact with Evomela

Evomela generic

Evomela is the trademark brand name for melphalan manufactured by Acrotech Biopharma LLC. A generic version of melphalan is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Evomela savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.