Imcivree Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Imcivree cost savings if eligible

If you are eligible to receive your Imcivree prescription through the patient assistance program, your medication will be free. We charge a flat monthly service fee of $49 per medication to cover the cost of our services.

Am I eligible for Imcivree patient assistance?

To be eligible for the Imcivree patient assistance program, you will need to meet specific eligibility criteria set by the pharmaceutical company. At NiceRx, we review each Imcivree enrollment application individually. The main factors considered are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Imcivree patient assistance program?

Applying for the Imcivree patient assistance program through NiceRx is simple. Begin by completing the enrollment application on our website. We will ask for details about your healthcare provider, your insurance plan, and your household income. This information is required by the pharmaceutical manufacturers that supply your medication. We may be able to help you access patient assistance for other medications as well as Imcivree, so please tell us about any medications that you have been prescribed.

If we determine that you may be eligible for Imcivree assistance, we will handle the full enrollment process on your behalf. We will work with your healthcare provider to prepare and submit all the documents required for you to enroll. If you are successfully enrolled in the Imcivree patient assistance program, we will also request your Imcivree medication refills on your behalf for up to 1 year. At the end of your enrollment period, we will contact you for updated details and seek to re-enroll you in the program.

Is NiceRx an Imcivree coupon provider?

NiceRx does not provide Imcivree coupons, discount cards or copay cards. We do not offer printable Imcivree manufacturer coupons, Imcivree discounts, rebates, Imcivree savings cards, trial offers, or free samples. We are a service provider that helps eligible individuals access patient assistance programs. Our service cost is $49 a month per medication, so you will likely save more on your Imcivree medication with NiceRx.

Can NiceRx help me get Imcivree cheaper if I have insurance?

NiceRx may be able to help you access Imcivree patient assistance if:

  • You have a high copay or coinsurance responsibility for Imcivree
  • Your insurance company will not pay for your Imcivree prescription
  • You do not have insurance

Complete your enrollment application online to find out more.

How much does Imcivree cost without insurance?

Imcivree prices without insurance will vary by retailer. As a guide, Imcivree will typically cost around $330 per milligram for an adult at the recommended dose of 3 mg per day.

How much does Imcivree cost with insurance?

Your individual healthcare plan will determine the copay of Imcivree with insurance. To find out what you will need to pay, contact your pharmacist or insurance provider. They will be able to calculate your copay with your current insurance.

What is Imcivree?

Imcivree is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Rhythm Pharmaceutical, Inc. Imcivree is a melanocortin 4 (MC4) receptor agonist indicated for chronic weight management (weight loss and weight maintenance for at least one year) in adult and pediatric patients 6 years of age and older with obesity (adults had a body mass index (BMI) of 30 kg/m2 or more) due to proopiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1 (PCSK1), or leptin receptor (LEPR) deficiency confirmed by genetic testing demonstrating variants in POMC, PCSK1, or LEPR genes that are interpreted as pathogenic, likely pathogenic, or of uncertain significance (VUS). 8 out of 10 people lost at least 10% of their body weight at 1 year of treatment with Imcivree.

The limitations of the use of Imcivree are that it is not indicated for the treatment of patients with obesity due to suspected POMC-, PCSK1-, or LEPR-deficiency with POMC, PCSK1, or LEPR variants classified as benign or likely benign, or other types of obesity not related to POMC, PCSK1 or LEPR deficiency, including obesity-associated with other genetic syndromes and general (polygenic) obesity.

What doses of Imcivree are available?

Imcivree is available in injection form, in the following doses: 10 mg/mL solution in a 1 mL multiple-dose vial.

The starting dose in adults and pediatric patients 12 years of age and older is 2 mg (0.2 mL) injected subcutaneously once daily for 2 weeks. If the starting dose is not tolerated, reduce to 1 mg (0.1 mL) once daily. If the 1 mg once daily dose is tolerated and additional weight loss is desired, titrate to 2 mg (0.2 mL) once daily. If the 2 mg daily dose is tolerated, increase the dose to 3 mg (0.3 mL) once daily. If the 3 mg once daily dose is not tolerated, maintain the administration of 2 mg (0.2 mL) once daily. The starting dose in pediatric patients 6 to less than 12 years of age is 1 mg (0.1 mL) injected subcutaneously once daily for 2 weeks.

Always speak with your healthcare provider about any changes to your dose so they can monitor and evaluate your condition.

Imcivree active ingredients

Imcivree contains the active ingredient setmelanotide.

Imcivree side effects

The most common side effects of Imcivree in clinical trials include:

  • Injection site reactions
  • Skin hyperpigmentation
  • Nausea, vomiting
  • Headache
  • Diarrhea, abdominal pain
  • Back pain
  • Tiredness
  • Upper respiratory tract infection

In rare instances, Imcivree can cause more serious adverse effects. These can include:

  • Disturbance in sexual arousal – spontaneous penile erections in males and sexual adverse reactions in females
  • Depression and suicidal ideation
  • Skin hyperpigmentation and darkening of pre-existing Nevi
  • Risk of serious adverse reactions including “gasping syndrome” due to benzyl alcohol preservative in neonates and low birth weight infants

Your doctor will assess the benefits of using Imcivree against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Imcivree to the FDA. Visit, or call 1-800-FDA-1088.

Imcivree drug interactions

Other drugs may interact with Imcivree, including prescription drugs and over-the-counter medicines, vitamins, and herbal products. Tell your health care provider about all of your medicines including any supplements you are taking.

Imcivree contraindications

You should not use Imcivree if you:

  • Are allergic to the active ingredient setmelanotide
  • Are allergic to any of the other ingredients in Imcivree
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed

Talk to your doctor before using Imcivree if you:

  • Are taking any of the medications that could interact with Imcivree
  • Have depression, or a history of depression
  • Have kidney disease
  • Have obesity caused by other genetic conditions

Imcivree generic

Imcivree is the trademark brand name for setmelanotide manufactured by Rhythm Pharmaceutical, Inc. A generic version of setmelanotide is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Imcivree savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.