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Medically reviewed by  Jamie Winn, PharmD

Your monthly Inrebic cost savings if eligible

If you are eligible for the Inrebic patient assistance program, the cost of your medication will be free. We only charge $49 per month for each medication, to cover our service fees. You could receive your Inrebic prescription for just $49 a month, regardless of the retail price of your medication.

Am I eligible for the Inrebic patient assistance program?

We will review your application to determine whether you are eligible for the Inrebic patient assistance program. Each program has its own eligibility criteria which are set by the pharmaceutical companies, however, the factors considered by most programs are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Inrebic patient assistance program?

We make it as easy as possible to apply for the Inrebic patient assistance program. The first step is to complete our enrollment application. Tell us about any medications you are taking, including Inrebic. We will also ask for details about your healthcare provider, insurance, and your household income. This information is required by the pharmaceutical manufacturers who ship your medication.

If we determine that you may be eligible for Inrebic assistance, we will handle the application process for you. We will work directly with your healthcare provider to prepare your application documents. Once we have received the signed application and supporting documents, we will submit them to the patient assistance program on your behalf. Our service continues once you are enrolled in the Inrebic patient assistance program, and we will automatically request your Inrebic medication refills for up to 1 year.

Is NiceRx an Inrebic coupons provider?

We are a service provider that helps eligible individuals access the Inrebic patient assistance program. That means that we do not offer printable Inrebic manufacturer coupons, Inrebic discounts, or free Inrebic samples. We are not an Inrebic coupon provider or Inrebic discount card. Our service extends to assisting eligible individuals to access the medications they need through patient assistance programs.

Can NiceRx help me get Inrebic if I have insurance?

We may be able to help you to access Inrebic patient assistance in a variety of circumstances. This includes when your insurance company will not pay for your Inrebic medication or if you have a high copay or coinsurance responsibility. We may also be able to help you if you do not have insurance. Please apply online to find out more.

How much does Inrebic cost without insurance?

Inrebic cost without insurance will vary depending on where you buy it. As a guide, Inrebic oral capsules 100 mg usually cost $22,900 for 120 capsules. With NiceRx you will pay a flat monthly fee of $49, regardless of the retail price of your medication.

How much does Inrebic cost with insurance?

The copay for Inrebic with insurance depends on the terms of your healthcare plan. To find out how much this is, your healthcare provider or pharmacist will be able to calculate your copay with your current insurance.

What is Inrebic?

Inrebic is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Celgene Corporation, a Bristol-Myers Squibb company.

Inrebicis a kinase inhibitor used for the treatment of adult patients with intermediate-2 or high-risk primary or secondary (post-polycythemia vera or post-essential thrombocythemia) myelofibrosis (MF). Myelofibrosis is a serious and rare bone marrow disorder that disrupts the body’s normal production of blood cells.

See the full prescribing information for a complete boxed warning. Serious and fatal encephalopathy, including Wernicke’s, has occurred in patients treated with Inrebic. Wernicke’s encephalopathy is a neurologic emergency. Assess thiamine levels in all patients prior to starting and periodically during treatment, and as clinically indicated. Do not start treatment in patients with thiamine deficiency, replete thiamine prior to treatment initiation. If encephalopathy is suspected, immediately discontinue treatment and initiate parenteral thiamine. Monitor until symptoms resolve or improve and thiamine levels normalize.

What doses of Inrebic are available?

Inrebic is available in capsule form, in the following doses: 100 mg.

The recommended dosage is 400 mg orally once daily with or without food for patients with a baseline platelet count of greater than or equal to 50 x 109/L. Take with a high-fat meal if Inrebic upsets your stomach. Reduce the dose for patients taking strong CYP3A inhibitors or with severe renal impairment.

Your vitamin B1 (thiamine) levels will be checked before and during treatment with Inrebic. You may need to take a vitamin B1 supplement. Always speak with your healthcare provider about any changes to your dose so they can monitor and evaluate your condition.

Inrebic active ingredients

Fedratinib is an oral kinase inhibitor with activity against wild type and mutationally activated Janus Associated Kinase 2 (JAK2) and FMS-like tyrosine kinase 3 (FLT3). Abnormal activation of JAK2 is associated with myeloproliferative neoplasms (MPNs), including myelofibrosis and polycythemia vera.

In cell models expressing mutationally active JAK2V617F or FLT3ITD, fedratinib reduced phosphorylation of signal transducer and activator of transcription (STAT3/5) proteins, inhibited cell growth, and spread, and induced cell death. In mouse models of JAK2V617F-driven myeloproliferative disease, fedratinib blocks phosphorylation of STAT3/5 improves survival, white blood cell counts, hematocrit, splenomegaly, and fibrosis.

Inrebic side effects

The most common side effects of Inrebic in clinical trials include:

  • Diarrhea, nausea, vomiting
  • Elevated creatinine

In rare instances, Inrebic can cause more serious side effects. These can include:

  • Anemia and thrombocytopenia
  • Gastrointestinal toxicity
  • Hepatic toxicity
  • Amylase and lipase elevation

Your healthcare professional will assess the benefits of using Inrebic against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Inrebic to the FDA. Visit, or call 1-800-FDA-1088.

Inrebic drug interactions

Inrebic can interact with other medications. These include:

  • Strong CYP3A4 Inhibitors
  • Strong and moderate CYP3A4 Inducers
  • Dual CYP3A4 and CYP2C19 Inhibitors
  • CYP2D6 substrates

This list is not exhaustive and other prescription drugs may interact with Inrebic.

Inrebic contraindications

You should not use Inrebic if you:

  • Are allergic to the active ingredient fedratinib
  • Are allergic to any of the other ingredients in Inrebic
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed, and for 1 month after your last dose
  • Have a severe hepatic impairment

Talk to your doctor before using Inrebic if you:

  • Are taking any of the medications that could interact with Inrebic
  • Have low levels of platelets or red blood cells
  • Have liver disease or kidney disease
  • Have been taking ruxolitinib (Jakafi)

Inrebic generic

Inrebic is the trademark brand name for fedratinib manufactured by Celgene Corporation a Bristol-Myers Squibb company. A generic version of fedratinib is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Inrebic savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.