Isturisa Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Isturisa cost savings if eligible

The Isturisa patient assistance program can provide your medication for free. We simply charge $49 per month for each medication to cover the cost of our services. With NiceRx, you will only pay $49 to obtain your Istursia, regardless of the retail price.

Am I eligible for the Isturisa patient assistance program?

To find out if you are eligible for Isturisa assistance you can apply online using our enrollment application. Each pharmaceutical company sets its eligibility criteria, and we will review your application individually to determine if you may be eligible. The three main factors to consider are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Isturisa patient assistance program?

Our application process aims to make it as easy as possible to apply for the Isturisa patient assistance program. The first step is to complete our online enrollment application. We will ask you for details about your healthcare provider, your insurance plan, and your household income as this information is required by the pharmaceutical companies. We may be able to help you apply for other patient assistance programs too, so be sure to tell us about any medications you are taking as well as Isturisa.

NiceRx will review your application and determine whether you may be eligible for Isturisa assistance. If so, we will handle the full enrollment process for you and prepare all required documents for your healthcare provider to sign. Once you are successfully enrolled in the Isturisa patient assistance program, we will help you manage your prescription refills by requesting refills on your behalf throughout your enrollment period. At the end of your enrollment period, we will contact you for updated information and seek to re-enroll you so you can continue to access affordable Isturisa.

Is NiceRx an Isturisa coupons provider?

NiceRx is a service provider that helps eligible individuals access the Isturisa patient assistance program. We do not offer trial offers or free Isturisa samples. When obtaining your medication through NiceRx, you will only pay $49 a month per medication. This will likely save you more money than if you were to use Isturisa coupons, discount cards, or Isturisa copay cards.

Can NiceRx help me get Isturisa if I have insurance?

NiceRx may be able to help you if your insurance company will not pay for your Isturisa medication. We may also be able to help if you have a high copay or coinsurance responsibility. Whether you have insurance or not, apply online using our enrollment application to find out more.

How much does Isturisa cost without insurance?

Isturisa prices without insurance will vary depending on how much you buy. Prices will also vary by retailer. As a guide, Isturisa oral tablets 1 mg typically cost $2,770 for 20 tablets.

How much does Isturisa cost with insurance?

The copay for Isturisa will vary by the terms of your healthcare plan. To find out what you might need to pay for Isturisa with insurance, your insurance provider or pharmacist will be able to help you calculate the copay costs with your current insurance.

What is Isturisa?

Isturisa is an FDA (U.S. Food and Drug Administration) approved medication distributed by Recordati Rare Disease, Inc.

Isturisa is a cortisol synthesis inhibitor indicated for the treatment of Cushing’s disease in adult patients for whom pituitary surgery is not an option or has not been curative. Cushing’s disease is a severe, rare endocrine disease. When the excessive adrenocorticotropic hormone is released due to enlargement of the pituitary gland or by a pituitary tumor, the adrenal glands get stimulated to produce a large amount of cortisol, which causes Cushing’s disease.

Isturisa blocks the activity of an enzyme involved in the production of cortisol called 11-beta-hydroxylase. This reduces the amount of cortisol made in the adrenal glands, helping patients with Cushing’s syndrome reach and maintain normal cortisol levels.

What doses of Isturisa are available?

Isturisa is available in tablet form, in the following doses: 1 mg, 5 mg, and 10 mg.

Correct hypokalemia and hypomagnesemia, and obtain baseline electrocardiogram before starting treatment. Initiate dosage at 2 mg orally twice daily, with or without food. Titrate the dosage by 1 to 2 mg twice daily, no more frequently than every 2 weeks based on the rate of cortisol changes, individual tolerability, and improvement in signs and symptoms. The maximum recommended dosage is 30 mg twice daily. See the full prescribing information for complete titration, laboratory, and dosage modification recommendations.

Always speak with a healthcare professional about any changes to your dose so they can monitor and evaluate your condition.

Isturisa active ingredients

Isturisa contains the active ingredient osilodrostat, which is classed as an adrenal corticosteroid inhibitor.

Isturisa side effects

The most common side effects of Isturisa in clinical trials compared to placebo include:

  • Adrenal insufficiency
  • Tiredness
  • Nausea, headache
  • Swelling of the legs, ankles, or other signs of fluid retention (edema)

In rare instances, Isturisa can cause more serious side effects. These can include:

  • Hypocortisolism – low blood pressure, stomach pain, loss of appetite, dizziness
  • QTc Prolongation
  • Elevations in adrenal hormone precursors and androgens. Monitor for hypokalemia, worsening of hypertension (high blood pressure), edema, and hirsutism

Your doctor will assess the benefits of using Isturisa against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Isturisa to the FDA. Visit, or call 1-800-FDA-1088.

Isturisa drug interactions

Isturisa can interact with other medications. These include:

  • CYP3A4 Inhibitor
  • CYP3A4 and CYP2B6 Inducers

This list is not exhaustive and other prescription drugs may interact with Isturisa. Tell your healthcare provider about all the medicines you take, including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements.

Isturisa contraindications

You should not use Isturisa if you:

  • Are allergic to the active ingredient osilodrostat
  • Are allergic to any of the other ingredients in Isturisa
  • Are breastfeeding or are planning to breastfeed
  • Are younger than 18 years of age

Talk to your doctor before using Isturisa if you:

  • Are taking any of the medications that could interact with Isturisa
  • Are pregnant or are planning to become pregnant
  • Have a heart rhythm disorder, long QT syndrome, congestive heart failure, or high blood pressure
  • Have an electrolyte imbalance (such as low levels of potassium or magnesium in your blood)
  • Have fluid retention
  • Have liver disease

Isturisa generic

Isturisa is the trademark brand name for osilodrostat distributed by Recordati Rare Disease, Inc. A generic version of osilodrostat is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Isturisa savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.