Koselugo Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Koselugo cost savings if eligible

If you are eligible for the Koselugo patient assistance program, the cost of your medication will be free. We only charge $49 per month for each medication, to cover our service fees. You could receive your Koselugo prescription for just $49 a month, regardless of the retail price of your medication.

Am I eligible for the Koselugo patient assistance program?

We will review your application to determine whether you are eligible for the Koselugo patient assistance program. Each program has its own eligibility criteria which are set by the pharmaceutical companies, however, the factors considered by most programs are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Koselugo patient assistance program?

We make it as easy as possible to apply for the Koselugo patient assistance program. The first step is to complete our enrollment application. Tell us about any medications you are taking, including Koselugo. We will also ask for details about your healthcare provider, insurance, and your household income. This information is required by the pharmaceutical manufacturers who ship your medication.

If we determine that you may be eligible for Koselugo assistance, we will handle the application process for you. We will work directly with your healthcare provider to prepare your application documents. Once we have received the signed application and supporting documents, we will submit them to the patient assistance program on your behalf. Our service continues once you are enrolled in the Koselugo patient assistance program, and we will automatically request your Koselugo medication refills for up to 1 year.

Is NiceRx a Koselugo coupons provider?

We are a service provider that helps eligible individuals access the Koselugo patient assistance program. That means that we do not offer printable Koselugo manufacturer coupons, Koselugo discounts, or free Koselugo samples. We are not a Koselugo coupon provider or Koselugo discount card. Our service extends to assisting eligible individuals to access the medications they need through patient assistance programs.

Can NiceRx help me get Koselugo if I have insurance?

We may be able to help you to access Koselugo patient assistance in a variety of circumstances. This includes when your insurance company will not pay for your Koselugo medication or if you have a high copay or coinsurance responsibility. We may also be able to help you if you do not have insurance. Please apply online to find out more.

How much does Koselugo cost without insurance?

Koselugo’s cost without insurance will vary depending on where you buy it. As a guide, Koselugo oral capsules 10 mg usually cost $2,300 for 28 capsules. With NiceRx you will pay a flat monthly fee of $49, regardless of the retail price of your medication.

How much does Koselugo cost with insurance?

The copay for Koselugo with insurance depends on the terms of your healthcare plan. To find out how much this is, your healthcare provider or pharmacist will be able to calculate your copay with your current insurance.

What is Koselugo?

Koselugo is an FDA (U.S. Food and Drug Administration) approved medication manufactured by AstraZeneca Pharmaceuticals lp. It is a kinase inhibitor for the treatment of pediatric patients 2 years of age and older with neurofibromatosis type 1 (NF1) who have symptomatic, inoperable plexiform neurofibromas (PN).

The FDA approved Koselugo based on a clinical trial conducted by the National Cancer Institute (NCI) of pediatric patients who had NF1 and inoperable PN.

What doses of Koselugo are available?

Koselugo is available in capsule form, in the following doses: 10 mg and 25 mg.

The recommended dose is 25 mg/m2 orally twice daily on an empty stomach until disease progression or unacceptable toxicity. Do not consume food 2 hours before or 1 hour after each dose. Reduce the dosage to 20 mg/m2 orally twice daily for patients with moderate hepatic impairment.

Always speak with a healthcare professional about any changes to your dose so they can monitor and evaluate your condition.

Koselugo active ingredients

Koselugo contains the active ingredient selumetinib, an inhibitor of mitogen-activated protein kinase, kinases 1 and 2 (MEK1/2). Both MEK and ERK are critical parts of the RAS-regulated RAF-MEK-ERK pathway, which is often activated in different types of cancers.

Koselugo side effects

The most common side effects of Koselugo in clinical trials include:

  • Vomiting, abdominal pain, diarrhea, bowel dysfunction, nausea
  • Dry skin, acneiform rash, stomatitis
  • Fatigue, musculoskeletal pain
  • Pyrexia, headache
  • Paronychia, pruritus

In rare instances, Koselugo can cause more serious side effects. These can include:

  • Cardiomyopathy
  • Ocular Toxicity – carry out ophthalmic assessments before and during treatment. Stop treatment if retinal vein occlusion (RVO) occurs. Withhold treatment if retinal pigment epithelial detachment (RPED) occurs, resume at a lower dose
  • Gastrointestinal Toxicity
  • Skin Toxicity
  • Increased Creatinine Phosphokinase (CPK)
  • Increased Vitamin E Levels and risk of bleeding

Your doctor will assess the benefits of using Koselugo against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Koselugo to the FDA. Visit, or call 1-800-FDA-1088.

Koselugo drug interactions

Koselugo can interact with other medications. These include:

  • Strong or Moderate CYP3A4 Inhibitors or Fluconazole
  • Strong or Moderate CYP3A4 Inducers

This list is not exhaustive and other prescription medicines may interact with Koselugo. Talk to your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, or herbal supplements.

Koselugo contraindications

You should not use Koselugo if you:

  • Are allergic to the active ingredient selumetinib
  • Are allergic to any of the other ingredients in Koselugo
  • Are pregnant or are planning to become pregnant – Koselugo can harm your unborn baby. Females who could become pregnant and males with female partners who could become pregnant should use birth control (contraception) during treatment and for 1 week after your last dose

Talk to your doctor before using Koselugo if you:

  • Are taking any of the medications that could interact with Koselugo
  • Are breastfeeding or are planning to breastfeed – do not breastfeed during treatment and for 1 week after your last dose

Koselugo generic

Koselugo is the trademark brand name for selumetinib manufactured by AstraZeneca pharmaceuticals lp. A generic version of selumetinib is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Koselugo savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.