Lomotil Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Lomotil cost savings if eligible

If you are eligible for the Lomotil patient assistance program, the cost of your medication will be free. We only charge $49 per month for each medication, to cover our service fees. You could receive your Lomotil prescription for just $49 a month, regardless of the retail price of your medication.

Am I eligible for the Lomotil patient assistance program?

We will review your application to determine whether you are eligible for the Lomotil patient assistance program. Each program has its own eligibility criteria which are set by the pharmaceutical companies, however, the factors considered by most programs are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Lomotil patient assistance program?

We make it as easy as possible to apply for the Lomotil patient assistance program. The first step is to complete our enrollment application. Tell us about any medications you are taking, including Lomotil. We will also ask for details about your healthcare provider, insurance, and your household income. This information is required by the pharmaceutical manufacturers who ship your medication.

If we determine that you may be eligible for Lomotil assistance, we will handle the application process for you. We will work directly with your healthcare provider to prepare your application documents. Once we have received the signed application and supporting documents, we will submit them to the patient assistance program on your behalf. Our service continues once you are enrolled in the Lomotil patient assistance program, and we will automatically request your Lomotil medication refills for up to 1 year.

Is NiceRx a Lomotil coupons provider?

We are a service provider that helps eligible individuals access the Lomotil patient assistance program. That means that we do not offer printable Lomotil manufacturer coupons, Lomotil discounts, or free Lomotil samples. We are not a Lomotil coupon provider or Lomotil discount card. Our service extends to assisting eligible individuals to access the medications they need through patient assistance programs.

Can NiceRx help me get Lomotil if I have insurance?

We may be able to help you to access Lomotil patient assistance in a variety of circumstances. This includes when your insurance company will not pay for your Lomotil medication or if you have a high copay or coinsurance responsibility. We may also be able to help you if you do not have insurance. Please apply online to find out more.

How much does Lomotil cost without insurance?

Lomotil cost without insurance will vary depending on where you buy it. As a guide, Lomotil oral tablet (0.025 mg-2.5 mg) usually costs $320 for 100 tablets. With NiceRx you will pay a flat monthly fee of $49, regardless of the retail price of your medication.

How much does Lomotil cost with insurance?

The copay for Lomotil with insurance depends on the terms of your healthcare plan. To find out how much this is, your healthcare provider or pharmacist will be able to calculate your copay with your current insurance.

What is Lomotil?

Lomotil is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Greenstone LLC. Lomotil tablets contain 2.5 mg of diphenoxylate hydrochloride and 0.025 mg of atropine sulfate.

Atropine is classed as an anticholinergic and helps to reduce spasms in the bladder, stomach, and intestines. Diphenoxylate is an antidiarrheal medication. Lomotil is used to treat diarrhea and to decrease the number and frequency of bowel movements.

Lomotil is used in the management of diarrhea in patients 13 years of age and older. It is not known if Lomotil is safe and effective in children younger than 2 years of age.

Lomotil is classed as a Schedule V controlled substance by federal regulation. Diphenoxylate hydrochloride is chemically related to the narcotic analgesic meperidine. In doses used for the treatment of diarrhea, whether acute or chronic, diphenoxylate has not produced addiction. Diphenoxylate hydrochloride does not have morphine-like subjective effects at therapeutic doses, but at high doses, it exhibits codeine-like subjective effects. The dose which produces an antidiarrheal effect is widely separated from the dose which causes central nervous system effects.

What doses of Lomotil are available?

Lomotil is available in tablet form, in the following doses: 2.5 mg of diphenoxylate hydrochloride and 0.025 mg of atropine sulfate.

You should drink plenty of liquids to keep from getting dehydrated while you have diarrhea. Your doctor may recommend an electrolyte supplement while you are taking Lomotil.

Store Lomotil tablets at room temperature away from moisture and heat, where a child cannot reach it. An overdose of atropine and diphenoxylate can be fatal to a child.

Please see the full drug information for patient safety information and always speak with your healthcare provider for medical advice or about any changes to your dose so they can monitor and evaluate your condition.

Lomotil active ingredients

Lomotil contains diphenoxylate hydrochloride and atropine sulfate as the active ingredient.

Lomotil side effects

The most common side effects of Lomotil in clinical trials include:

  • Drowsiness, dizziness
  • Headache
  • Numbness in your hands or feet
  • Depression
  • Confusion
  • Red or swollen gums
  • Dry mouth, nose, or throat
  • Nausea, vomiting, upset stomach, loss of appetite
  • Skin rash, dryness, or itching

In rare instances, Lomotil can cause more serious side effects. These can include:

  • Severe constipation, stomach pain, or bloating
  • Ongoing or worsening diarrhea
  • Severe pain in your upper stomach spreading to your back
  • Fever
  • Hallucinations, seizure
  • Rapid breathing, weak or shallow breathing
  • Fast heart rate
  • Dehydration symptoms–feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin.

Your doctor will assess the benefits of using Lomotil against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Lomotil to the FDA. Visit, or call 1-800-FDA-1088.

Lomotil drug interactions

Lomotil can interact with other medications. These include:

  • Alcohol
  • Other drugs that cause CNS depression – barbiturates, benzodiazepines, opioids, buspirone, antihistamines, muscle relaxants
  • Monoamine oxidase inhibitors (MAO) inhibitors – diphenoxylate may interact with (MAOIs) to cause a hypertensive crisis (headache, hyperthermia, hypertension)

This list is not exhaustive and other prescription drugs may interact with Lomotil. Talk with your doctor and pharmacist. Tell them about all prescription drugs, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use.

Lomotil contraindications

You should not use Lomotil if you:

  • Are allergic to the active ingredient atropine and diphenoxylate
  • Have had an allergic reaction to any of the other ingredients in Lomotil
  • Have diarrhea that is caused by bacteria or by taking an antibiotic
  • Have obstructive jaundice

Talk to your doctor about your medical condition before using Lomotil if you:

  • Are taking any of the medications that could interact with Lomotil
  • Have a blockage in your intestines
  • Have ulcerative colitis
  • Have asthma or other breathing problems
  • Have glaucoma
  • Have urination problems
  • Have liver or kidney disease
  • Have Down’s syndrome
  • Are dehydrated
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed – this medication passes into breast milk

Lomotil generic

Lomotil is the trademark brand name for atropine and diphenoxylate manufactured by Greenstone LLC. A generic version of atropine and diphenoxylate is available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Lomotil savings through NiceRx.

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The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.