Mytesi Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Mytesi cost savings if eligible

The Mytesi patient assistance program can provide your medication for free. We simply charge $49 per month for each medication to cover the cost of our services. With NiceRx, you will only pay $49 to obtain your Mytesi, regardless of the retail price.

Am I eligible for the Mytesi patient assistance program?

To find out if you are eligible for Mytesi assistance you can apply online using our enrollment application. Each pharmaceutical company sets its eligibility criteria, and we will review your application individually to determine if you may be eligible. The three main factors to consider are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Mytesi patient assistance program?

Our application process aims to make it as easy as possible to apply for the Mytesi patient assistance program. The first step is to complete our online enrollment application. We will ask you for details about your healthcare provider, your insurance plan, and your household income as this information is required by the pharmaceutical companies. We may be able to help you apply for other patient assistance programs too, so be sure to tell us about any medications you are taking as well as Mytesi.

NiceRx will review your application and determine whether you may be eligible for Mytesi assistance. If so, we will handle the full enrollment process for you and prepare all required documents for your healthcare provider to sign. Once you are successfully enrolled in the Mytesi patient assistance program, we will help you manage your prescription refills by requesting refills on your behalf throughout your enrollment period. At the end of your enrollment period, we will contact you for updated information and seek to re-enroll you so you can continue to access affordable Mytesi.

Is NiceRx a Mytesi coupon provider?

NiceRx is a service provider that helps eligible individuals access the Mytesi patient assistance program. We do not offer trial offers or free Mytesi samples. When obtaining your medication through NiceRx, you will only pay $49 a month per medication. This will likely save you more money than if you were to use Mytesi coupons, discount cards, or Mytesi copay cards.

Can NiceRx help me get Mytesi cheaper if I have insurance?

NiceRx may be able to help you if your insurance company will not pay for your Mytesi medication. We may also be able to help if you have a high copay or coinsurance responsibility. Whether you have insurance or not, apply online using our enrollment application to find out more.

How much does Mytesi cost without insurance?

Mytesi prices without insurance will vary depending on how much you buy. Prices will also vary by retailer. As a guide, Mytesi oral delayed-release tablet 125 mg typically costs $2,400 for 60 tablets.

How much does Mytesi cost with insurance?

The copay for Mytesi will vary by the terms of your healthcare plan. To find out what you might need to pay for Mytesi with insurance, your insurance provider or pharmacist will be able to help you calculate the copay costs with your current insurance.

What is Mytesi?

Mytesi is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Patheon Pharmaceuticals Inc. for Napo Pharmaceuticals, Inc. Mytesi is an anti-diarrheal indicated for the symptomatic relief of non-infectious diarrhea in adult patients with HIV/AIDS on antiretroviral therapy who have had an inadequate response, intolerable side effects, or contraindication with either loperamide or diphenoxylate/atropine.

Crofelemer, the active ingredient in Mytesi, is a plant-based drug extracted and purified from the red bark sap of the medicinal Croton lechleri tree in the Amazon rainforest.

What doses of Mytesi are available?

Mytesi is available in delayed-release tablets form, in the following doses: 125 mg.

Before starting Mytesi, rule out infectious etiologies of diarrhea. The recommended adult dosage is 125 mg taken orally twice a day, with or without food. Do not crush or chew the tablets. Swallow the tablets whole.

Please read the full prescribing information and always speak with your healthcare provider for medical advice about any changes to your dose so they can monitor and evaluate your condition.

Mytesi active ingredients

Mytesi contains crofelemer as the active ingredient. Crofelemer is an inhibitor of both the cyclic adenosine monophosphate (cAMP)-stimulated cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion (Cl‾) channel and the calcium-activated Cl‾ channels (CaCC) at the luminal membrane of enterocytes.

Crofelemer acts by blocking Cl‾ secretion and accompanying high volume water loss in diarrhea, normalizing the flow of Cl‾ and water in the gastrointestinal tract.

Mytesi side effects

The most common side effects of Mytesi in placebo-controlled clinical trials include:

  • Upper respiratory tract infection
  • Flatulence
  • Bronchitis
  • Cough
  • Increased bilirubin
  • Nausea
  • Back pain
  • Joint pain
  • Urinary tract infection (UTI)
  • runny or stuffy nose,
  • Musculoskeletal pain
  • Hemorrhoids
  • Anxiety
  • Bloating

Your doctor will assess the benefits of using Mytesi against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Mytesi to the FDA. Visit, or call 1-800-FDA-1088.

Mytesi drug interactions

Other drugs may interact with Mytesi, including prescription drugs and over-the-counter medicines, vitamins, and herbal products. Tell your health care provider about all of your medicines including any supplements you are taking.

Mytesi contraindications

You should not use Mytesi if you:

  • Are allergic to the active ingredient crofelemer
  • Are allergic to any of the other ingredients in Mytesi
  • Are pregnant or are planning to become pregnant

Talk to your doctor before using Mytesi if you:

  • Are taking any of the medications that could interact with Mytesi
  • Are breastfeeding or are planning to breastfeed – It is unknown if this medication passes into breast milk

Mytesi generic

Mytesi is the trademark brand name for crofelemer manufactured by Patheon Pharmaceuticals Inc. A generic version of crofelemer is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Mytesi savings through NiceRx.

Related conditions

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.