Ongentys Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Ongentys cost savings if eligible

With our assistance, you could access the Ongentys patient assistance program and obtain your medication for free. We only charge a flat monthly fee of $49 per medication for our services.

Am I eligible for Ongentys patient assistance?

We review each Ongentys enrollment application individually to determine if you are eligible. Each assistance program has its own eligibility criteria and the factors considered by most programs are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Ongentys patient assistance program?

Our process makes it as easy as possible to apply for the Ongentys patient assistance program. Begin by completing the enrollment application form on our website. Tell us about any medications that you are taking, including Ongentys, your healthcare provider, your insurance plan, and your household income. This information is required by the pharmaceutical manufacturers who will supply the medication, so it is important to make sure this information is accurate and up to date.

We will review the information that you have provided to determine whether you are eligible for patient assistance. If we can pre-qualify you for assistance, NiceRx will handle the full enrollment process on your behalf. If you are approved by the pharmaceutical company, you will typically start receiving your medication in 6 – 8 weeks.

Is NiceRx an Ongentys coupons provider?

NiceRx is not an Ongentys coupon, Ongentys discount card, or Ongentys copay card provider. We do not offer Ongentys manufacturer coupons, Ongentys discounts, rebates, Ongentys savings cards, trial offers, or free Ongentys samples. We are a service provider that helps eligible individuals access their medication directly from the U.S. pharmaceutical company.

Can NiceRx help me if I have insurance?

NiceRx may be able to help you if:

  • You have a high copay or coinsurance responsibility for Ongentys
  • Your insurance company will not pay for your Ongentys prescription
  • Your healthcare plan does not cover your medication
  • You do not have insurance

Please apply online to find out if we can help you.

How much does Ongentys cost without insurance?

Without insurance, Ongentys costs will vary depending on where you buy the medication as prices will vary by retailer. As a guide, Ongentys oral capsule 25 mg will cost around $625 for 30 capsules.

How much does Ongentys cost with insurance?

The copay for Ongentys will depend on the terms of your healthcare plan. Your healthcare provider or pharmacist will be able to calculate your copay with your current insurance. Contact them to find out more.

What is Ongentys?

Ongentys is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Neurocrine Biosciences Inc. Ongentys is a catechol-O-methyltransferase (COMT) inhibitor used as adjunctive treatment to levodopa/carbidopa in patients with Parkinson’s disease (PD) experiencing “off” episodes or off time.

What doses of Ongentys are available?

Ongentys is available in capsule form, in the following doses: 25 mg and 50 mg.

The recommended dose is 50 mg orally once daily at bedtime. Patients should not eat food for 1 hour before and for at least 1 hour after taking Ongentys. The recommended dose in patients with moderate hepatic impairment is 25 mg orally once daily at bedtime. If a dose is missed, skip the missed dose and take the next dose at the regular time (the next day at bedtime).

Always speak with your healthcare provider for medical advice or about any changes to your dose so they can monitor and evaluate your condition.

Ongentys active ingredients

The active ingredient of Ongentys is opicapone, it is classed as a COMT inhibitor and is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT).

Physiological substrates of COMT include DOPA, catecholamines (dopamine, norepinephrine, and epinephrine), and their hydroxylated metabolites. When decarboxylation of levodopa is prevented by carbidopa, COMT becomes the major metabolizing enzyme for levodopa.

Ongentys side effects

The most common side effects of Ongentys in clinical trials include:

  • Constipation
  • Increased blood creatine kinase
  • Hypotension (low blood pressure), lightheadedness
  • Syncope
  • Weight loss

In rare instances, Ongentys can cause more serious adverse effects. These can include:

  • Arrhythmias, increased heart rate
  • Drowsiness
  • Dyskinesia – consider levodopa or dopaminergic medication dose reduction
  • Hallucinations and psychosis
  • Impulse Control/Compulsive Disorders – sexual urges, unusual urges to gamble, binge eating, or other intense urges
  • Withdrawal-Emergent Hyperpyrexia and Confusion – when discontinuing Ongentys monitor patients and consider adjustment of other dopaminergic therapies

Your healthcare professional will assess the benefits of using Ongentys against your risk of possible side effects. Patients are encouraged to report negative side effects or adverse reactions of Ongentys to the FDA. Visit, or call 1-800-FDA-1088.

Ongentys drug interactions

Ongentys can interact with other medications. These include:

  • MAO inhibitors such as isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine

This list is not exhaustive and other prescription drugs may interact with Ongentys. Tell your healthcare provider about all the medicines you take, including prescription drugs and over-the-counter medicines, vitamins, and herbal supplements.

Ongentys contraindications

You should not use Ongentys if you:

  • Are allergic to the active ingredient opicapone
  • Are allergic to any of the other ingredients in Ongentys
  • Have pheochromocytoma (tumor of the adrenal gland)
  • Have paraganglioma (tumor of the nerve cells)
  • Have other catecholamine secreting neoplasms

Talk to your doctor before using Ongentys if you:

  • Are taking any of the medications that could interact with Ongentys
  • Are breastfeeding or are planning to breastfeed
  • Are taking non-selective monoamine oxidase (MAO) inhibitors
  • Are pregnant or are planning to become pregnant – may cause fetal harm
  • Have a sleep disorder that causes daytime sleepiness
  • Have uncontrolled muscle movements
  • Have liver disease
  • Have kidney disease

Ongentys generic

Ongentys is the trademark brand name for opicapone manufactured by Neurocrine Biosciences Inc. A generic version of opicapone is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Ongentys savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.