Onivyde Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Onivyde cost savings if eligible

If you are eligible to receive your Onivyde prescription through the patient assistance program, your medication will be free. We charge a flat monthly service fee of $49 per medication to cover the cost of our services.

Am I eligible for Onivyde patient assistance?

To be eligible for the Onivyde patient assistance program, you will need to meet specific eligibility criteria set by the pharmaceutical company. At NiceRx, we review each Onivyde enrollment application individually. The main factors considered are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Onivyde patient assistance program?

Applying for the Onivyde patient assistance program through NiceRx is simple. Begin by completing the enrollment application on our website. We will ask for details about your healthcare provider, your insurance plan, and your household income. This information is required by the pharmaceutical manufacturers that supply your medication. We may be able to help you access patient assistance for other medications as well as Onivyde, so please tell us about any medications that you have been prescribed.

If we determine that you may be eligible for Onivyde assistance, we will handle the full enrollment process on your behalf. We will work with your healthcare provider to prepare and submit all the documents required for you to enroll. If you are successfully enrolled in the Onivyde patient assistance program, we will also request your Onivyde medication refills on your behalf for up to 1 year. At the end of your enrollment period, we will contact you for updated details and seek to re-enroll you in the program.

Is NiceRx an Onivyde coupons provider?

NiceRx does not provide Onivyde coupons, discount cards, or copay cards. We do not offer printable Onivyde manufacturer coupons, Onivyde discounts, rebates, Onivyde savings cards, trial offers, or free samples. We are a service provider that helps eligible individuals access patient assistance programs. Our service cost is $49 a month per medication, so you will likely save more on your Onivyde medication with NiceRx.

Can NiceRx help me get Onivyde if I have insurance?

NiceRx may be able to help you access Onivyde patient assistance if:

  • You have a high copay or coinsurance responsibility for Onivyde
  • Your insurance company will not pay for your Onivyde prescription
  • You do not have insurance

Complete your enrollment application online to find out more.

How much does Onivyde cost without insurance?

Onivyde prices without insurance will vary by retailer. As a guide, Onivyde intravenous dispersion (4.3 mg/mL) will typically cost around $2,600 for a supply of 10 milliliters.

How much does Onivyde cost with insurance?

Your individual healthcare plan will determine the copay of Onivyde with insurance. To find out what you will need to pay, contact your pharmacist or insurance provider. They will be able to calculate your copay with your current insurance.

What is Onivyde?

Onivyde is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Ipsen Biopharmaceuticals, Inc. Onivyde is a topoisomerase inhibitor indicated, in combination with 5 fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancreas (metastatic pancreatic cancer) after disease progression following gemcitabine-based therapy. It is not indicated as a single agent for the treatment of patients with metastatic adenocarcinoma of the pancreas.

See the full prescribing information for a complete boxed warning. Fatal neutropenic sepsis occurred in 0.8% of patients receiving Onivyde. Severe or life-threatening neutropenic fever or sepsis occurred in 3% and severe or life-threatening neutropenia occurred in 20% of patients receiving Onivyde in combination with fluorouracil and leucovorin. Withhold Onivyde for absolute neutrophil counts below 1500/mm3 or neutropenic fever. Monitor blood cell counts regularly during treatment.

Severe diarrhea occurred in 13% of patients receiving Onivyde in combination with fluorouracil and leucovorin. Do not give Onivyde to patients with bowel obstruction. Withhold treatment for diarrhea of Grade 2-4. Administer loperamide for late diarrhea of any severity. Administer atropine, if not contraindicated, for early diarrhea of any severity.

What doses of Onivyde are available?

Onivyde is available in injection form, in the following doses: 43 mg/10 mL single-dose vial.

Do not substitute Onivyde for other drugs containing irinotecan HCl. The recommended starting dose of Onivyde in patients homozygous for UGT1A1*28 is 50 mg/m2 every two weeks. There is no recommended dose for patients with serum bilirubin above the upper limit of normal.

Always speak with a healthcare professional about any changes to your dose so they can monitor and evaluate your condition.

Onivyde active ingredients

Irinotecan liposome injection is the active ingredient in Onivyde.

Onivyde side effects

The most common side effects of Onivyde in clinical trials include:

  • Diarrhea
  • Fatigue/asthenia
  • Vomiting, nausea
  • Decreased appetite
  • Stomatitis
  • Pyrexia
  • Lymphopenia neutropenia, and thrombocytopenia

In rare instances, Onivyde can cause more serious adverse reactions. These can include:

  • Interstitial lung disease (ILD)
  • Severe hypersensitivity reaction: Permanently discontinue ONIVYDE for severe hypersensitivity reactions

Your doctor will assess the benefits of using Onivyde against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Onivyde to the FDA. Visit, or call 1-800-FDA-1088.

Onivyde drug interactions

Onivyde can interact with other medications. These include:

  • Strong CYP3A4 inducers – substitute non-enzyme inducing therapies at least 2 weeks before Onivyde treatment
  • Avoid the use of strong CYP3A4 or UGT1A1 inhibitors

This list is not exhaustive and other prescription drugs may interact with Onivyde.

Onivyde contraindications

You should not use Onivyde if you:

  • Are allergic to the active ingredient irinotecan
  • Are allergic to any of the other ingredients in Onivyde
  • Have had a severe hypersensitivity reaction to Onivyde or irinotecan HCl
  • Are pregnant or are planning to become pregnant – Embryo-fetal toxicity. Females of reproductive potential are advised to use effective contraception

Talk to your doctor before using Onivyde if you:

  • Are taking any of the medications that could interact with Onivyde
  • Are breastfeeding or are planning to breastfeed

Onivyde generic

Onivyde is the trademark brand name for irinotecan manufactured by Ipsen Biopharmaceuticals, Inc. A generic version of irinotecan is available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Onivyde savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.