Opdualag Coupon & Prices

Is your Opdualag medication too expensive? Start receiving your medication for only $49 per month.*

Complete a free online enrollment application to find out if you’re eligible to pay only $49 per month for your Opdualag medication with our help.

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  • NiceRx Benefit
    Secure: Your personal and medical information is safe with us
  • NiceRx Benefit
    Convenient: We manage the whole process and we’re here to assist you
  • NiceRx Benefit
    Ongoing refills: We request your medication refills on your behalf
  • NiceRx Benefit
    Secure: Your personal and medical information is safe with us
  • NiceRx Benefit
    Convenient: We manage the whole process and we’re here to assist you
  • NiceRx Benefit
    Ongoing refills: We request your medication refills on your behalf

NiceRx works with your healthcare provider to help you access affordable medications directly from U.S. pharmaceutical companies.

How it works

  • Enroll online

    Get started by filling out the online enrollment application to find out if you are eligible for assistance.

  • Pre-qualification

    NiceRx verifies your eligibility for medication assistance and notifies you if you are pre-qualified. The pharmaceutical company provides your medication for free, and you only pay our service fee.

  • Submit documents

    We will request documents to be submitted by you and your healthcare provider that are required by the pharmaceutical company to complete your enrollment.

  • Receive medication

    Once approved, the pharmaceutical company typically ships a 90-day supply of medication to your home or healthcare provider’s address. Final acceptance is determined by the pharmaceutical company.

Medically reviewed by  Jamie Winn, PharmD

Your monthly Opdualag cost savings if eligible

If you are eligible for the Opdualag patient assistance program you can receive your medication for free. Our monthly service fee of $49 per medication covers the cost of our services in applying for the program and requesting your ongoing refills on your behalf. If you obtain your Opdualag through NiceRx, you will only pay $49 a month regardless of the retail price of your medication.

Am I eligible for the Opdualag patient assistance program?

You could receive your Opdualag without paying the full retail price if you meet the eligibility criteria for assistance. The eligibility requirements are set by the pharmaceutical companies that are providing assistance programs. At NiceRx, we review each application individually, although the main factors considered by most programs are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for Opdualag patient assistance?

We do everything that we can to take the hassle and stress out of applying for patient assistance programs. Simply start by filling in our enrollment application. We will ask for details about your healthcare provider, your insurance, and your household income. This information is required by the pharmaceutical companies you are applying to for assistance. We may also be able to help you access patient assistance for other medications that you have been prescribed, so be sure to tell us about any medications you are taking as well as Opdualag.

NiceRx will review the information you have provided, and if we determine that you may be eligible for assistance, we will seek to enroll you in the Opdualag patient assistance program. We will handle the enrollment process for you by working with your healthcare provider and preparing all the required paperwork for your doctor to sign. We will also request your Opdualag medication refills on your behalf for up to 1 year once you are enrolled in the program.

Is NiceRx an Opdualag coupon provider?

At NiceRx, we help eligible individuals access the Opdualag patient assistance program. This means that we are not an Opdualag coupon, an Opdualag discount card, or an Opdualag copay card provider. We do not offer any medication trial offers, or free Opdualag samples.

Can NiceRx help me get Opdualag cheaper if I have insurance?

We may be able to help you if you have insurance, including if your insurance company will not pay for your Opdualag medication, or if you have a high copay or coinsurance responsibility. We may even be able to assist if you do not have insurance. Please fill in our enrollment application to find out more.

How much does Opdualag cost without insurance?

Opdualag costs without insurance will vary depending on how much you buy and the retailer you buy it from. As a guide, Opdualag intravenous solution (rmbw 240 mg-80 mg/20 mL) will typically cost around $14,400 for 20 milliliters. If you obtain your medication through NiceRx, you will pay a flat monthly rate of $49 per medication regardless of its retail price.

How much does Opdualag cost with insurance?

The copay of Opdualag will vary in line with the specific terms of your healthcare plan. For further details about what you may need to pay, your insurance provider or pharmacist will be able to calculate the copay costs with your current insurance.

What is Opdualag?

Opdualag is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Bristol-Myers Squibb (BMS). Approval of Opdualag was based on results from a study called the RELATIVITY-047 trial which compared the combination of nivolumab and relatlimab with nivolumab alone. The trial met its primary endpoint, progression-free survival (PFS), and Opdualag more than doubled the median PFS when compared to nivolumab monotherapy. Combination results in increased T-cell activation compared to the activity of either antibody alone.

Opdualag is a combination immunotherapy of nivolumab, a programmed death receptor-1 (PD-1) blocking antibody, and relatlimab, a lymphocyte activation gene-3 (LAG-3) blocking antibody. I is indicated for the treatment of adult and pediatric patients 12 years of age or older with unresectable or metastatic melanoma.

What doses of Opdualag are available?

Opdualag is available in injection form, in the following doses: 240 mg of nivolumab and 80 mg of relatlimab per 20 mL (12 mg and 4 mg per mL) in a single-dose vial.

The recommended dose for adult patients and pediatric patients 12 years of age or older who weigh at least 40 kg is 480 mg nivolumab and 160 mg relatlimab as an intravenous infusion over 30 minutes every 4 weeks. Your caregiver will check you for side effects during treatment, and may treat you with corticosteroids or hormone replacement medicines.

See the full prescribing information for dosage modifications for adverse reactions and preparation and administration instructions for the injection, and always speak with a healthcare professional about any changes to your dose so they can monitor and evaluate your condition.

Opdualag active ingredients

Opdualag contains nivolumab and relatlimab-rmbw as the active ingredients.

Opdualag side effects

The most common side effects of Opdualag in clinical trials include:

  • Nausea, headache
  • Diarrhea, loss of appetite
  • Tiredness
  • Musculoskeletal pain
  • Pruritus
  • Laboratory abnormalities include decreased hemoglobin, lymphocytes, and sodium, and increased AST and ALT

In rare instances, Opdualag can cause more serious side effects. These can include:

  • Hormone gland problems such as thyroid, pituitary, adrenal, or pancreas
  • Immune-mediated adverse reactions – immune-mediated pneumonitis, colitis, hepatitis, endocrinopathies, dermatologic adverse reactions, immune-mediated nephritis with renal dysfunction, and immune-mediated myocarditis
  • Infusion-related reactions
  • Complications of allogeneic HSCT – fatal and other serious complications can occur in patients who receive allogeneic HSCT before or after being treated with a PD-1/PD-L1 blocking antibody
  • Embryo-fetal toxicity – females of reproductive potential should use effective contraception

Your doctor will assess the benefits of using Opdualag against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Opdualag to the FDA. Visit, or call 1-800-FDA-1088.

Opdualag drug interactions

Other drugs may interact with Opdualag, including prescription drugs and over-the-counter medicines, vitamins, and herbal products. Tell your health care provider about all of your medication including any supplements you are taking.

Opdualag contraindications

You should not use Opdualag if you:

  • Are allergic to the active ingredients nivolumab and relatlimab-rmbw
  • Are allergic to any of the other ingredients in Opdualag
  • Are pregnant or are planning to become pregnant – use an effective method of birth control during treatment and for at least 5 months after your last dose

Talk to your doctor before using Opdualag if you:

  • Are taking any of the medications that could interact with Opdualag
  • Have immune system problems such as Crohn’s disease, ulcerative colitis, or lupus
  • Have received an organ transplant
  • Plan to receive a stem cell transplant that uses donor stem cells (allogeneic)
  • Have a condition such as myasthenia gravis or Guillain-Barré syndrome
  • Are breastfeeding or are planning to breastfeed – It is not known if Opdualag passes into breast milk

Opdualag generic

Opdualag is the trademark brand name for nivolumab and relatlimab-rmbw manufactured by Bristol-Myers Squibb Company. A generic version of nivolumab and relatlimab-rmbw is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Opdualag savings through NiceRx.

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*Qualifying persons may obtain medications directly from patient assistance programs without any out-of-pocket cost (or for less than $49 per medication). However, our monthly flat rate of just $49 per medication spares you the hassle of tracking the different programs and filling out all the required paperwork for each program. Subject to medication availability and acceptance by the pharmaceutical companies. NiceRx is not responsible for any delays or rejection by the pharmaceutical companies.

Enrollees enjoy a full-service solution, as NiceRx assists them and their physicians with the entire process. We prepare all required documents for the physician to sign, help enrollees manage all prescription refills, monitor eligibility criteria, and maintain enrollment.

**If you do not receive medications because you were determined to be ineligible for the prescription assistance by the applicable pharmaceutical companies and you have a letter of denial, we will refund any fees you paid toward medications for which you did not qualify to receive prescription assistance (“Refund”).

To receive a refund, you must send the letter of denial to us by fax to 888-517-7444, or by e-mail to [email protected] within 30 days of your receipt of such letter. The Refund is your sole and exclusive remedy for any fees you may wish to dispute.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.