Opzelura Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Opzelura cost savings if eligible

The Opzelura patient assistance program can provide your medication for free. We simply charge $49 per month for each medication to cover the cost of our services. With NiceRx, you will only pay $49 to obtain your Opzelura, regardless of the retail price.

Am I eligible for the Opzelura patient assistance program?

To find out if you are eligible for Opzelura assistance you can apply online using our enrollment application. Each pharmaceutical company sets its eligibility criteria, and we will review your application individually to determine if you may be eligible. The three main factors to consider are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Opzelura patient assistance program?

Our application process aims to make it as easy as possible to apply for the Opzelura patient assistance program. The first step is to complete our online enrollment application. We will ask you for details about your healthcare provider, your insurance plan, and your household income as this information is required by the pharmaceutical companies. We may be able to help you apply for other patient assistance programs too, so be sure to tell us about any medications you are taking as well as Opzelura.

NiceRx will review your application and determine whether you may be eligible for Opzelura assistance. If so, we will handle the full enrollment process for you and prepare all required documents for your healthcare provider to sign. Once you are successfully enrolled in the Opzelura patient assistance program, we will help you manage your prescription refills by requesting refills on your behalf throughout your enrollment period. At the end of your enrollment period, we will contact you for updated information and seek to re-enroll you so you can continue to access affordable Opzelura.

Is NiceRx an Opzelura coupon provider?

NiceRx is a service provider that helps eligible individuals access the Opzelura patient assistance program. We do not offer trial offers or free Opzelura samples. When obtaining your medication through NiceRx, you will only pay $49 a month per medication. This will likely save you more money than if you were to use Opzelura coupons, discount cards, or Opzelura copay cards.

Can NiceRx help me get Opzelura cheaper if I have insurance?

NiceRx may be able to help you if your insurance company will not pay for your Opzelura medication. We may also be able to help if you have a high copay or coinsurance responsibility. Whether you have insurance or not, apply online using our enrollment application to find out more.

How much does Opzelura cost without insurance?

Opzelura prices without insurance will vary depending on how much you buy. Prices will also vary by retailer. As a guide, Opzelura topical cream 1.5% typically costs $2,100 for a supply of 60 grams.

How much does Opzelura cost with insurance?

The copay for Opzelura will vary by the terms of your healthcare plan. To find out what you might need to pay for Opzelura with insurance, your insurance provider or pharmacist will be able to help you calculate the copay costs with your current insurance.

What is Opzelura?

Opzelura is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Incyte Corporation. It is classed as a Janus kinase inhibitor for the short-term and non-continuous treatment of atopic dermatitis (eczema) in non-immunocompromised adolescent patients 12 years of age and older whose disease is not controlled well enough with prescription therapies or when those therapies are not recommended.

The use of Opzelura with other therapeutic biologics, JAK inhibitors or potent immunosuppressants such as azathioprine or cyclosporine is not recommended.

What doses of Opzelura are available?

Opzelura is available as ruxolitinib cream, in the following doses: 1.5%

Apply a thin layer of cream twice daily to the affected areas of up to 20% body surface area. Do not use more than 60 grams per week. Opzelura is for topical use only and is not for ophthalmic, oral, or intravaginal use.

Please see the full prescribing information for the complete boxed warning and always speak with your healthcare provider about any changes to your dose so they can monitor and evaluate your condition.

Opzelura active ingredients

Ruxolitinib, the active ingredient in Opzelura blocks JAK1 and JAK2 which control the signaling of cytokines and growth factors that are important for hematopoiesis and immune function.

Opzelura side effects

The most common side effects of Opzelura in clinical trials include:

  • Nasopharyngitis
  • Diarrhea
  • Bronchitis
  • Ear infection
  • Eosinophil count increased
  • Urticaria
  • Folliculitis
  • Tonsillitis
  • Rhinorrhea

In rare instances, Opzelura can cause more serious side effects. These can include:

  • Increases in lipid parameters including total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides
  • Serious infections leading to hospitalization or death, including tuberculosis and bacterial, invasive fungal, viral, and other infections
  • Higher rate of all-cause mortality, including sudden cardiovascular death
  • Lymphoma and other malignancies
  • A higher rate of major adverse cardiovascular events (MACE), including cardiovascular death, myocardial infarction, and stroke
  • Thrombosis, including deep venous thrombosis, pulmonary embolism, and arterial thrombosis, some fatal, have occurred in patients treated for inflammatory conditions
  • Non-melanoma skin cancers
  • Thrombocytopenia, anemia, and neutropenia

Your doctor will assess the benefits of using Opzelura against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Opzelura to the FDA. Visit, or call 1-800-FDA-1088.

Opzelura drug interactions

Opzelura can interact with other medications. These include:

  • Strong inhibitors of CYP3A4
  • Inducers of CYP3A4

This list is not exhaustive and other prescription drugs may interact with Opzelura.

Opzelura contraindications

You should not use Opzelura if you:

  • Are allergic to the active ingredient ruxolitinib
  • Are allergic to any of the other ingredients in Opzelura
  • Are pregnant or are planning to become pregnant

Talk to your doctor before using Opzelura if you:

  • Are taking any of the medications that could interact with Opzelura
  • Have an infection that keeps coming back
  • Have diabetes, chronic lung disease, HIV, or a weak immune system
  • Have tuberculosis or have been in close contact with someone with tuberculosis
  • Have had shingles
  • Have had hepatitis B or C
  • Are breastfeeding or are planning to breastfeed

Opzelura generic

Opzelura is the trademark brand name for ruxolitinib manufactured by Incyte Corporation. A generic version of ruxolitinib is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Opzelura savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.