Orenitram Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Orenitram cost savings if eligible

If you are eligible to receive your Orenitram prescription through the patient assistance program, your medication will be free. We charge a flat monthly service fee of $49 per medication to cover the cost of our services.

Am I eligible for Orenitram patient assistance?

To be eligible for the Orenitram patient assistance program, you will need to meet specific eligibility criteria set by the pharmaceutical company. At NiceRx, we review each Orenitram enrollment application individually. The main factors considered are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Orenitram patient assistance program?

Applying for the Orenitram patient assistance program through NiceRx is simple. Begin by completing the enrollment application on our website. We will ask for details about your healthcare provider, your insurance plan, and your household income. This information is required by the pharmaceutical manufacturers that supply your medication. We may be able to help you access patient assistance for other medications as well as Orenitram, so please tell us about any medications that you have been prescribed.

If we determine that you may be eligible for Orenitram assistance, we will handle the full enrollment process on your behalf. We will work with your healthcare provider to prepare and submit all the documents required for you to enroll. If you are successfully enrolled in the Orenitram patient assistance program, we will also request your Orenitram medication refills on your behalf for up to 1 year. At the end of your enrollment period, we will contact you for updated details and seek to re-enroll you in the program.

Is NiceRx an Orenitram coupons provider?

NiceRx does not provide Orenitram coupons, discount cards or copay cards. We do not offer printable Orenitram manufacturer coupons, Orenitram discounts, rebates, Orenitram savings cards, trial offers, or free samples. We are a service provider that helps eligible individuals access patient assistance programs. Our service cost is $49 a month per medication, so you will likely save more on your Orenitram medication with NiceRx.

Can NiceRx help me get Orenitram if I have insurance?

NiceRx may be able to help you access Orenitram patient assistance if:

  • You have a high copay or coinsurance responsibility for Orenitram
  • Your insurance company will not pay for your Orenitram prescription
  • You do not have insurance

Complete your enrollment application online to find out more.

How much does Orenitram cost without insurance?

Orenitram prices without insurance will vary by retailer. As a guide, Orenitram oral tablets, extended-release 5 mg will typically cost around $2,600 for 10 tablets.

How much does Orenitram cost with insurance?

Your individual healthcare plan will determine the copay of Orenitram with insurance. To find out what you will need to pay, contact your pharmacist or insurance provider. They will be able to calculate your copay with your current insurance.

What is Orenitram?

Orenitram is an FDA (U.S. Food and Drug Administration) approved medication manufactured by United Therapeutics Corporation. Orenitram is a prostacyclin vasodilator indicated for the treatment of pulmonary arterial hypertension (common symptoms of PAH include tiredness and shortness of breath or difficulty breathing, especially when doing daily activities) (WHO Group 1) to improve exercise capacity.

The study that established effectiveness included predominately patients with WHO (World Health Organization) functional class II-III symptoms and etiologies of idiopathic or heritable PAH (75%) or PAH associated with connective tissue disease (19%). As the sole vasodilator, the effect on exercise is small. Orenitram has not been shown to add to other vasodilator therapy.

What doses of Orenitram are available?

Orenitram is available in extended-release tablet form, in the following doses: 0.125 mg, 0.25 mg, 1 mg, and 2.5 mg.

The recommended starting dose is 0.25 mg orally every 12 hours with food. The total daily dose can be divided and given every 8 hours with food, in titrations of 0.125 mg 3 times daily.
The maximum dose will depend on tolerability. The maximum dose studied was 21 mg orally every 12 hours with food.

Do not crush, chew, or break an extended-release tablet. Swallow the tablet whole. Orenitram is made with a shell that is not absorbed in the body and part of the tablet shell may appear in your stool. Call your doctor if you have new or worsening PAH symptoms such as shortness of breath (even with mild exertion), tiredness, chest pain, and pale skin.

Store the tablets at room temperature away from moisture and heat. Read the full patient information and the additional information supplied with your medication. Always speak with your healthcare provider for medical advice or about any changes to your dose so they can monitor and evaluate your condition.

Orenitram active ingredients

Orenitram contains treprostinil as the active ingredient.

Orenitram side effects

The most common side effects of Orenitram in clinical trials compared to placebo include:

  • Headache
  • Nausea
  • Diarrhea

In rare instances, Orenitram can cause more serious adverse effects. These can include:

  • Abrupt discontinuation of Orenitram may cause worsening of your PAH symptoms
  • Increased risk of bleeding, particularly if you are receiving anticoagulants
  • In patients with diverticulosis, Orenitram tablets can become lodged in a diverticulum

Your doctor will assess the benefits of using Orenitram against your risk of adverse events. Patients are encouraged to report negative side effects or adverse reactions of Orenitram to the FDA. Visit, or call 1-800-FDA-1088.

Orenitram drug interactions

Orenitram can interact with other medications. These include:

  • Blood pressure-lowering drugs, such as diuretics, antihypertensive agents, or vasodilators
  • Strong CYP2C8 inhibitors
  • Do not take Orenitram with alcohol

This list is not exhaustive and other prescription drugs may interact with Orenitram.

Orenitram contraindications

You should not use Orenitram if you:

  • Are allergic to the active ingredient treprostinil
  • Are allergic to any of the other ingredients in Orenitram
  • Have severe hepatic impairment (Child-Pugh Class C)
  • Are pregnant or are planning to become pregnant – animal reproductive studies have shown an adverse effect on the fetus

Talk to your doctor about your medical condition before using Orenitram if you:

  • Are taking any of the medications that could interact with Orenitram
  • Have diverticulosis
  • Take another medicine that contains treprostinil, such as Remodulin, or Tyvaso
  • Are breastfeeding or are planning to breastfeed – it is not known if Orenitram passes into your breast milk

Orenitram generic

Orenitram is the trademark brand name for treprostinil manufactured by United Therapeutics Corporation. A generic version of treprostinil is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Orenitram savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.