Orfadin Coupon & Prices
Complete a free online enrollment application to find out if you’re eligible to pay only $49 per month for your Orfadin medication with our help.Get Started Now
Secure: Your personal and medical information is safe with us
Convenient: Your medication is delivered straight to your door
Ongoing refills: Your medication is refilled automatically
Secure: Your personal and medical information is safe with us
Convenient: We manage the whole process and we’re here to assist you
Ongoing refills: We request your medication refills on your behalf
NiceRx works with your healthcare provider to help you access affordable medications directly from U.S. pharmaceutical companies.
How it works
Get started by filling out the online enrollment application to find out if you are eligible for assistance.
NiceRx verifies your eligibility for medication assistance and notifies you if you are pre-qualified. The pharmaceutical company provides your medication for free, and you only pay our service fee.
We will request documents to be submitted by you and your healthcare provider that are required by the pharmaceutical company to complete your enrollment.
Once approved, the pharmaceutical company typically ships a 90-day supply of medication to your home or healthcare provider’s address. Final acceptance is determined by the pharmaceutical company.
Your monthly Orfadin cost savings if eligible
With our assistance, you could access the Orfadin patient assistance program and obtain your medication for free. We only charge a flat monthly fee of $49 per medication for our services.
Am I eligible for Orfadin patient assistance?
We review each Orfadin enrollment application individually to determine if you are eligible. Each assistance program has its own eligibility criteria and the factors considered by most programs are:
- I am a permanent, legal resident of the United States or Puerto Rico
- I am uninsured or my insurance doesn’t cover my medication
- I meet certain income eligibility requirements
How do I apply for the Orfadin patient assistance program?
Our process makes it as easy as possible to apply for the Orfadin patient assistance program. Begin by completing the enrollment application form on our website. Tell us about any medications that you are taking, including Orfadin, your healthcare provider, your insurance plan, and your household income. This information is required by the pharmaceutical manufacturers who will supply the medication, so it is important to make sure this information is accurate and up to date.
We will review the information that you have provided to determine whether you are eligible for patient assistance. If we can pre-qualify you for assistance, NiceRx will handle the full enrollment process on your behalf. If you are approved by the pharmaceutical company, you will typically start receiving your medication in 6 – 8 weeks.
Is NiceRx an Orfadin coupon provider?
NiceRx is not an Orfadin coupon, Orfadin discount card, or Orfadin copay card provider. We do not offer Orfadin manufacturer coupons, Orfadin discounts, rebates, Orfadin savings cards, trial offers, or free Orfadin samples. We are a service provider that helps eligible individuals access their medication directly from the U.S. pharmaceutical company.
Can NiceRx help me get Orfadin cheaper if I have insurance?
NiceRx may be able to help you if:
- You have a high copay or coinsurance responsibility for Orfadin
- Your insurance company will not pay for your Orfadin prescription
- Your healthcare plan does not cover your medication
- You do not have insurance
Please apply online to find out if we can help you.
How much does Orfadin cost without insurance?
Without insurance, Orfadin costs will vary depending on where you buy the medication as prices will vary by retailer. As a guide, Orfadin oral capsules 2 mg will cost around $5,750 for 60 capsules.
How much does Orfadin cost with insurance?
The copay for Orfadin will depend on the terms of your healthcare plan. Your healthcare provider or pharmacist will be able to calculate your copay with your current insurance. Contact them to find out more.
What is Orfadin?
Orfadin is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Apotek Produktion & Laboratorier AB, Sweden. and marketed by Swedish Orphan Biovitrum (Sobi). It is a 4-hydroxyphenylpyruvate dioxygenase inhibitor indicated for the treatment of hereditary tyrosinemia type 1 (HT-1) as an adjunct to dietary restriction of tyrosine and phenylalanine.
What doses of Orfadin are available?
Orfadin is available in capsule form, in the following doses: 2 mg, 5 mg, 10 mg, 20 mg, and as an oral suspension, in the following dose: 4 mg/mL.
The recommended initial daily dose is 0.5 mg/kg orally twice daily and based on body weight. Titrate the dose based on biochemical and/or clinical response, as described in the full prescribing information. The maximum dosage is 1 mg/kg orally twice daily.
Take Orfadin capsules at least one hour before, or two hours after a meal. If you have difficulties swallowing capsules and are intolerant to the oral suspension, the capsules may be opened and the contents suspended in a small amount of water, formula, or apple sauce immediately before use.
Restrict tyrosine and phenylalanine intake through your diet and always speak with a healthcare professional for medical advice about any changes to your dose so they can monitor and evaluate your condition.
Orfadin active ingredients
Patients with HT-1 and AKU lack enzymes to break down the amino acid tyrosine properly and, as a result, it is converted to harmful substances. The active ingredient in Orfadin, nitisinone, blocks the enzymes that convert tyrosine into harmful substances. Diet restrictions prevent excessive levels of amino acids such as tyrosine and of phenylalanine, which is converted into tyrosine in the body.
Orfadin side effects
The most common adverse reactions of Orfadin in clinical trials include:
- Elevated plasma tyrosine levels
- Thrombocytopenia (low platelets)
- Leukopenia (low white blood cell counts)
- Ocular symptoms – conjunctivitis, corneal opacity, keratitis, photophobia, eye pain, blepharitis, cataracts
- Pruritus, exfoliative dermatitis, dry skin, maculopapular rash
- Liver cancer, liver failure
- Doses of 20 mL of Orfadin oral suspension may cause headache, upset stomach, and diarrhea due to the glycerol content, consider switching patients to Orfadin capsules
Your doctor will assess the benefits of using Orfadin against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Orfadin to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Orfadin drug interactions
Orfadin can interact with other medications. These include:
- CYP2C9 substrates
This list is not exhaustive and other prescription drugs may interact with Orfadin.
You should not use Orfadin if you:
- Are allergic to the active ingredient nitisinone
- Are allergic to any of the other ingredients in Orfadin
Talk to your doctor before using Orfadin if you:
- Are taking any of the medications that could interact with Orfadin
- Are pregnant or are planning to become pregnant
- Are breastfeeding or are planning to breastfeed
Orfadin is the trademark brand name for nitisinone manufactured by Apotek Produktion & Laboratorier AB, Sweden., and marketed by Swedish Orphan Biovitrum (Sobi). A generic version of nitisinone is available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Orfadin savings through NiceRx.
*Qualifying persons may obtain medications directly from patient assistance programs without any out-of-pocket cost (or for less than $49 per medication). However, our monthly flat rate of just $49 per medication spares you the hassle of tracking the different programs and filling out all the required paperwork for each program. Subject to medication availability and acceptance by the pharmaceutical companies. NiceRx is not responsible for any delays or rejection by the pharmaceutical companies.
Enrollees enjoy a full-service solution, as NiceRx assists them and their physicians with the entire process. We prepare all required documents for the physician to sign, help enrollees manage all prescription refills, monitor eligibility criteria, and maintain enrollment.
**If you do not receive medications because you were determined to be ineligible for the prescription assistance by the applicable pharmaceutical companies and you have a letter of denial, we will refund any fees you paid toward medications for which you did not qualify to receive prescription assistance (“Refund”).
To receive a refund, you must send the letter of denial to us by fax to 888-517-7444, or by e-mail to [email protected] within 30 days of your receipt of such letter. The Refund is your sole and exclusive remedy for any fees you may wish to dispute.
The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.