Orkambi Coupon & Prices

Is your Orkambi medication too expensive? Start receiving your medication for only $49 per month.*

Complete a free online enrollment application to find out if you’re eligible to pay only $49 per month for your Orkambi medication with our help.

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  • NiceRx Benefit
    Secure: Your personal and medical information is safe with us
  • NiceRx Benefit
    Convenient: We manage the whole process and we’re here to assist you
  • NiceRx Benefit
    Ongoing refills: We request your medication refills on your behalf
  • NiceRx Benefit
    Secure: Your personal and medical information is safe with us
  • NiceRx Benefit
    Convenient: We manage the whole process and we’re here to assist you
  • NiceRx Benefit
    Ongoing refills: We request your medication refills on your behalf

NiceRx works with your healthcare provider to help you access affordable medications directly from U.S. pharmaceutical companies.

How it works

  • Enroll online

    Get started by filling out the online enrollment application to find out if you are eligible for assistance.

  • Pre-qualification

    NiceRx verifies your eligibility for medication assistance and notifies you if you are pre-qualified. The pharmaceutical company provides your medication for free, and you only pay our service fee.

  • Submit documents

    We will request documents to be submitted by you and your healthcare provider that are required by the pharmaceutical company to complete your enrollment.

  • Receive medication

    Once approved, the pharmaceutical company typically ships a 90-day supply of medication to your home or healthcare provider’s address. Final acceptance is determined by the pharmaceutical company.

Medically reviewed by  Jamie Winn, PharmD

Your monthly Orkambi cost savings if eligible

If you are eligible for the Orkambi patient assistance program you can receive your medication for free. Our monthly service fee of $49 per medication covers the cost of our services in applying for the program and requesting your ongoing refills on your behalf. If you obtain your Orkambi through NiceRx, you will only pay $49 a month regardless of the retail price of your medication.

Am I eligible for the Orkambi patient assistance program?

You could receive your Orkambi without paying the full retail price if you meet the eligibility criteria for assistance. The eligibility requirements are set by the pharmaceutical companies who are providing assistance programs. At NiceRx, we review each application individually, although the main factors considered by most programs are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for Orkambi patient assistance?

We do everything that we can to take the hassle and stress out of applying for patient assistance programs. Simply start by filling in our enrollment application. We will ask for details about your healthcare provider, your insurance, and your household income. This information is required by the pharmaceutical companies you are applying to for assistance. We may also be able to help you access patient assistance for other medications that you have been prescribed, so be sure to tell us about any medications you are taking as well as Orkambi.

NiceRx will review the information you have provided, and if we determine that you may be eligible for assistance, we will seek to enroll you in the Orkambi patient assistance program. We will handle the enrollment process for you by working with your healthcare provider and preparing all the required paperwork for your doctor to sign. We will also request your Orkambi medication refills on your behalf for up to 1 year once you are enrolled in the program.

Is NiceRx an Orkambi coupons provider?

At NiceRx, we help eligible individuals access the Orkambi patient assistance program. This means that we are not an Orkambi coupon, an Orkambi discount card, or an Orkambi copay card provider. We do not offer any medication trial offers, or free Orkambi samples.

Can NiceRx help me get Orkambi if I have insurance?

We may be able to help you if you have insurance, including if your insurance company will not pay for your Orkambi medication, or you have a high copay or coinsurance responsibility. We may even be able to assist if you do not have insurance. Please fill in our enrollment application to find out more.

How much does Orkambi cost without insurance?

Orkambi costs without insurance will vary depending on how much you buy and the retailer you buy it from. As a guide, Orkambi oral granules for reconstitution (125 mg-100 mg) will typically cost around $23,000 for 56 granules. If you obtain your medication through NiceRx, you will pay a flat monthly rate of $49 per medication regardless of its retail price.

How much does Orkambi cost with insurance?

The copay of Orkambi will vary in line with the specific terms of your healthcare plan. For further details about what you may need to pay, your insurance provider or pharmacist will be able to calculate the copay costs with your current insurance.

What is Orkambi?

Orkambi is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Vertex Pharmaceuticals Incorporated. It is a combination of lumacaftor and ivacaftor, a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, indicated for the treatment of cystic fibrosis (CF) in patients 2 years of age and older who are homozygous for the F508del mutation in the CFTR gene. If the patient’s genotype is unknown, an FDA-cleared CF mutation test should be used to detect the presence of the F508del mutation on both alleles of the CFTR gene.

The efficacy and safety of Orkambi have not been established in patients with CF other than those homozygous for the F508del mutation.

What doses of Orkambi are available?

Orkambi is available in tablet form, in the following doses: lumacaftor 100 mg and ivacaftor 125 mg, lumacaftor 200 mg and ivacaftor 125 mg.

Orkambi is available in granule form, in the following doses: Unit-dose packets of lumacaftor 100 mg and ivacaftor 125 mg, lumacaftor 150 mg and ivacaftor 188 mg.

Always speak with your healthcare provider about any changes to your dose so they can monitor and evaluate your condition.

Orkambi active ingredients

Orkambi contains the active ingredients lumacaftor and ivacaftor. These compounds target the defective chloride channels. Lumacaftor increases the amount of this channel on cell surfaces, while ivacaftor helps defective channels work better. Together, they maintain the balance between salt and water, keeping mucus from clogging the ducts of organs. Patients treated with Orkambi experience significant improvements in lung function.

Everyone inherits two copies of each gene, including the CFTR gene. More than 1,700 mutations have been found in the CFTR gene. Orkambi works for patients with the F508del mutation in both copies of the CFTR gene. This is the most common mutation in people with cystic fibrosis worldwide.

Orkambi side effects

The most common side effects of Orkambi in clinical trials compared to placebo include:

  • Dyspnea
  • Nasopharyngitis, runny nose
  • Nausea
  • Diarrhea
  • Upper respiratory tract infection
  • Fatigue
  • Blood creatine phosphokinase increased
  • Rash
  • Flatulence
  • Rhinorrhea
  • Cold symptoms

In rare instances, Orkambi can cause more serious side effects. These can include:

  • Shortness of breath, chest tightness
  • Liver problems – nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, yellowing of the skin or eyes
  • Increased blood pressure
  • Non-congenital lens opacities/cataracts have been reported in pediatric patients. Baseline and follow-up examinations are recommended in pediatric patients initiating treatment

Your doctor will assess the benefits of using Orkambi against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Orkambi to the FDA. Visit, or call 1-800-FDA-1088.

Orkambi drug interactions

Orkambi can interact with other medications. These include:

  • Strong CYP3A inhibitors – ketoconazole, itraconazole, posaconazole, voriconazole, telithromycin, clarithromycin
  • Strong CYP3A inducers – rifampin, rifabutin, phenobarbital, carbamazepine, phenytoin, and St. John’s wort (Hypericum perforatum)
  • CYP3A substrates – Benzodiazepines (midazolam, triazolam), Immunosuppressants (cyclosporine, everolimus, sirolimus, and tacrolimus)
  • CYP2B6 and CYP2C substrates
  • Digoxin and other P-gp substrates
  • Anti-allergics and systemic corticosteroids – montelukast, prednisone, and methylprednisolone
  • Antibiotics – clarithromycin, erythromycin, and telithromycin
  • Antifungals – itraconazole, ketoconazole, posaconazole, and voriconazole
  • Anti-inflammatories – ibuprofen
  • Antidepressants – citalopram, escitalopram, and sertraline
  • Hormonal contraceptives, including oral, injectable, transdermal, and implantable, should not be relied upon as an effective method of contraception when co-administered with Orkambi. Concomitant use with hormonal contraceptives increased menstrual abnormality events
  • Oral hypoglycemic – repaglinide, sulfonylurea
  • Proton Pump Inhibitors, H2 Blockers, Antacids – omeprazole, esomeprazole, lansoprazole, and ranitidine
  • Warfarin

This list is not exhaustive and other prescription drugs may interact with Orkambi.

Orkambi contraindications

You should not use Orkambi if you:

  • Are allergic to the active ingredient lumacaftor/ivacaftor
  • Are allergic to any of the other ingredients in Orkambi
  • Are pregnant or are planning to become pregnant

Talk to your doctor before using Orkambi if you:

  • Are taking any of the medications that could interact with Orkambi
  • Have liver disease – your liver function will be monitored
  • Have kidney disease
  • Have high blood pressure
  • Have asthma or other lung diseases
  • Have had an organ transplant
  • Are breastfeeding or are planning to breastfeed

Orkambi generic

Orkambi is the trademark brand name for lumacaftor/ivacaftor manufactured by Vertex Pharmaceuticals Incorporated. A generic version of lumacaftor/ivacaftor is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Orkambi savings through NiceRx.

Related conditions

*Qualifying persons may obtain medications directly from patient assistance programs without any out-of-pocket cost (or for less than $49 per medication). However, our monthly flat rate of just $49 per medication spares you the hassle of tracking the different programs and filling out all the required paperwork for each program. Subject to medication availability and acceptance by the pharmaceutical companies. NiceRx is not responsible for any delays or rejection by the pharmaceutical companies.

Enrollees enjoy a full-service solution, as NiceRx assists them and their physicians with the entire process. We prepare all required documents for the physician to sign, help enrollees manage all prescription refills, monitor eligibility criteria, and maintain enrollment.

**If you do not receive medications because you were determined to be ineligible for the prescription assistance by the applicable pharmaceutical companies and you have a letter of denial, we will refund any fees you paid toward medications for which you did not qualify to receive prescription assistance (“Refund”).

To receive a refund, you must send the letter of denial to us by fax to 888-517-7444, or by e-mail to [email protected] within 30 days of your receipt of such letter. The Refund is your sole and exclusive remedy for any fees you may wish to dispute.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.