Orladeyo Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Is NiceRx an Orladeyo coupon provider?

We are a service provider that helps eligible individuals access patient assistance programs. That means that we do not offer printable Orladeyo manufacturer coupons, Orladeyo discounts, or free Orladeyo samples. We are not an Orladeyo coupon provider or Orladeyo discount card. Our service extends to assisting eligible individuals to access the medications they need through patient assistance programs.

Orladeyo patient assistance program

Patient assistance programs are typically sponsored by pharmaceutical companies and provide free or discounted medications to individuals with low income who are uninsured or under-insured and meet the eligibility criteria that vary by program. There are currently no known patient assistance programs for this medication.

How much does Orladeyo cost without insurance?

Orladeyo cost without insurance will vary depending on where you buy it. As a guide, Orladeyo oral capsules 110 mg usually cost $40,500 for 28 capsules.

How much does Orladeyo cost with insurance?

The copay for Orladeyo with insurance depends on the terms of your healthcare plan. To find out how much this is, your healthcare provider or pharmacist will be able to calculate your copay with your current insurance.

What is Orladeyo?

Orladeyo is an FDA (U.S. Food and Drug Administration) approved medication manufactured for BioCryst Pharmaceuticals, Inc. FDA approval of Orladeyo is based on results from the APeX study.

Orladeyo is a plasma kallikrein inhibitor used for prophylaxis to prevent attacks of hereditary angioedema (HAE) in adults and pediatric patients 12 years of age and older. Orladeyo has a limitation of use, in that it should not be used for the treatment of acute HAE attacks.

What doses of Orladeyo are available?

Orladeyo is available in capsule form, in the following doses: 150 mg, and 110 mg.

The recommended dose of Orladeyo is one 150 mg capsule orally once daily with food. For patients with moderate or severe hepatic impairment, the recommended dose of Orladeyo is one 110 mg capsule taken once daily with food. The recommended dose for concomitant use with P-GP or BCRP inhibitors, such as cyclosporine is also one 110 mg capsule once daily with food.

Please see the full prescribing information and patient information and always speak with a healthcare professional for medical advice about any changes to your dose so they can monitor and evaluate your condition.

Orladeyo active ingredients

Orladeyo contains berotralstat as the active ingredient. By binding to kallikrein in the body it lowers the amount of bradykinin which causes symptoms during an attack of HAE.

Orladeyo side effects

The most common side effects of Orladeyo in clinical trials compared to placebo include:

  • Abdominal pain
  • Vomiting
  • Diarrhea
  • Back pain
  • Gastroesophageal reflux disease (heartburn)

In rare instances, Orladeyo can cause more serious side effects. These can include:

  • An increase in QT prolongation at doses higher than the recommended daily dose

Your doctor will assess the benefits of using Orladeyo against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Orladeyo to the FDA. Visit, or call 1-800-FDA-1088.

Orladeyo drug interactions

Orladeyo can interact with other medications. These include:

  • P-GP or BCRP inhibitors
  • P-GP inducers
  • CYP2D6, CYP3A4, or P-GP Substrates
  • St. John’s wort

This list is not exhaustive and other prescription drugs may interact with Orladeyo.

Orladeyo contraindications

You should not use Orladeyo if you:

  • Are allergic to the active ingredient berotralstat
  • Are allergic to any of the other ingredients in Orladeyo
  • Are pregnant or are planning to become pregnant

Talk to your doctor before using Orladeyo if you:

  • Are taking any of the medications that could interact with Orladeyo
  • Are breastfeeding or are planning to breastfeed

Orladeyo generic

Orladeyo is the trademark brand name for berotralstat manufactured for BioCryst Pharmaceuticals, Inc. A generic version of berotralstat is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Orladeyo savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.