Home / Medications / Orladeyo

Orladeyo Patient assistance program

Is your Orladeyo medication too expensive? Start receiving your medication for only $49 per month.*

Complete a free online enrollment application to find out if you’re eligible to pay only $49 per month for your Orladeyo medication with our help.

Get Started Now
  • NiceRx Benefit
    Secure: Your personal and medical information is safe with us
  • NiceRx Benefit
    Convenient: Your medication is delivered straight to your door
  • NiceRx Benefit
    Ongoing refills: Your medication is refilled automatically
  • NiceRx Benefit
    Secure: Your personal and medical information is safe with us
  • NiceRx Benefit
    Convenient: We manage the whole process and we’re here to assist you
  • NiceRx Benefit
    Ongoing refills: We request your medication refills on your behalf

NiceRx works with your healthcare provider to help you access affordable medications directly from U.S. pharmaceutical companies.

An introduction to NiceRx

Play video (01:52)
  • An introduction to NiceRx
  • Next steps after qualifying
  • Uploading documents and billing
  • SSN & billing information
  • Medication delivery time

How it works

  • Apply Online

    Get started by filling out the online enrollment application to find out if you are eligible.

  • Qualification

    NiceRx verifies your eligibility for medication assistance and notifies you if you are qualified. The pharmaceutical company provides your medication for free and you only pay our service fee.

  • Upload Documents

    You may be required to submit further information and documents required by the pharmaceutical company which can be securely uploaded online.

  • Application Created

    Your application is created and sent to your doctor for signature. At this stage, you will be billed $49 and will not be billed again until you receive your first medication delivery.

  • Receive Medication

    Your application is sent to the pharmaceutical company. You will be billed again once you receive your medication. We handle the entire ordering process including requesting ongoing refills.

Medically reviewed by  Jamie Winn, PharmD

Your monthly Orladeyo cost savings if eligible

If you are eligible for the Orladeyo patient assistance program, the cost of your medication will be free. We only charge $49 per month for each medication, to cover our service fees. You could receive your Orladeyo prescription for just $49 a month, regardless of the retail price of your medication.

Am I eligible for the Orladeyo patient assistance program?

We will review your application to determine whether you are eligible for the Orladeyo patient assistance program. Each program has its own eligibility criteria which are set by the pharmaceutical companies, however, the factors considered by most programs are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Orladeyo patient assistance program?

We make it as easy as possible to apply for the Orladeyo patient assistance program. The first step is to complete our enrollment application. Tell us about any medications you are taking, including Orladeyo. We will also ask for details about your healthcare provider, insurance, and your household income. This information is required by the pharmaceutical manufacturers who ship your medication.

If we determine that you may be eligible for Orladeyo assistance, we will handle the application process for you. We will work directly with your healthcare provider to prepare your application documents. Once we have received the signed application and supporting documents, we will submit them to the patient assistance program on your behalf. Our service continues once you are enrolled in the Orladeyo patient assistance program, and we will automatically request your Orladeyo medication refills for up to 1 year.

Is NiceRx an Orladeyo coupon provider?

We are a service provider that helps eligible individuals access the Orladeyo patient assistance program. That means that we do not offer printable Orladeyo manufacturer coupons, Orladeyo discounts, or free Orladeyo samples. We are not an Orladeyo coupon provider or Orladeyo discount card. Our service extends to assisting eligible individuals to access the medications they need through patient assistance programs.

Can NiceRx help me get Orladeyo cheaper if I have insurance?

We may be able to help you to access Orladeyo patient assistance in a variety of circumstances. This includes when your insurance company will not pay for your Orladeyo medication or if you have a high copay or coinsurance responsibility. We may also be able to help you if you do not have insurance. Please apply online to find out more.

How much does Orladeyo cost without insurance?

Orladeyo cost without insurance will vary depending on where you buy it. As a guide, Orladeyo oral capsules 110 mg usually cost $40,500 for 28 capsules. With NiceRx you will pay a flat monthly fee of $49, regardless of the retail price of your medication.

How much does Orladeyo cost with insurance?

The copay for Orladeyo with insurance depends on the terms of your healthcare plan. To find out how much this is, your healthcare provider or pharmacist will be able to calculate your copay with your current insurance.

What is Orladeyo?

Orladeyo is an FDA (U.S. Food and Drug Administration) approved medication manufactured for BioCryst Pharmaceuticals, Inc. FDA approval of Orladeyo is based on results from the APeX study.

Orladeyo is a plasma kallikrein inhibitor used for prophylaxis to prevent attacks of hereditary angioedema (HAE) in adults and pediatric patients 12 years of age and older. Orladeyo has a limitation of use, in that it should not be used for the treatment of acute HAE attacks.

What doses of Orladeyo are available?

Orladeyo is available in capsule form, in the following doses: 150 mg, and 110 mg.

The recommended dose of Orladeyo is one 150 mg capsule orally once daily with food. For patients with moderate or severe hepatic impairment, the recommended dose of Orladeyo is one 110 mg capsule taken once daily with food. The recommended dose for concomitant use with P-GP or BCRP inhibitors, such as cyclosporine is also one 110 mg capsule once daily with food.

Please see the full prescribing information and patient information and always speak with a healthcare professional for medical advice about any changes to your dose so they can monitor and evaluate your condition.

Orladeyo active ingredients

Orladeyo contains berotralstat as the active ingredient. By binding to kallikrein in the body it lowers the amount of bradykinin which causes symptoms during an attack of HAE.

Orladeyo side effects

The most common side effects of Orladeyo in clinical trials compared to placebo include:

  • Abdominal pain
  • Vomiting
  • Diarrhea
  • Back pain
  • Gastroesophageal reflux disease (heartburn)

In rare instances, Orladeyo can cause more serious side effects. These can include:

  • An increase in QT prolongation at doses higher than the recommended daily dose

Your doctor will assess the benefits of using Orladeyo against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Orladeyo to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Orladeyo drug interactions

Orladeyo can interact with other medications. These include:

  • P-GP or BCRP inhibitors
  • P-GP inducers
  • CYP2D6, CYP3A4, or P-GP Substrates
  • St. John’s wort

This list is not exhaustive and other prescription drugs may interact with Orladeyo.

Orladeyo contraindications

You should not use Orladeyo if you:

  • Are allergic to the active ingredient berotralstat
  • Are allergic to any of the other ingredients in Orladeyo
  • Are pregnant or are planning to become pregnant

Talk to your doctor before using Orladeyo if you:

  • Are taking any of the medications that could interact with Orladeyo
  • Are breastfeeding or are planning to breastfeed

Orladeyo generic

Orladeyo is the trademark brand name for berotralstat manufactured for BioCryst Pharmaceuticals, Inc. A generic version of berotralstat is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Orladeyo savings through NiceRx.

*Qualifying persons may obtain medications directly from patient assistance programs without any out-of-pocket cost (or for less than $49 per medication). However, our monthly flat rate of just $49 per medication spares you the hassle of tracking the different programs and filling out all the required paperwork for each program. Subject to medication availability.

Enrollees enjoy a full-service solution, as NiceRx assists them and their physicians with the entire process. We prepare all required documents for the physician to sign, help enrollees manage all prescription refills, monitor eligibility criteria, and maintain enrollment.

**If you do not receive medications because you were determined to be ineligible for the prescription assistance by the applicable pharmaceutical companies and you have a letter of denial, we will refund any fees you paid toward medications for which you did not qualify to receive prescription assistance (“Refund”).

To receive a refund, you must send the letter of denial to us by fax to 888-517-7444, or by e-mail to [email protected] within 30 days of your receipt of such letter. The Refund is your sole and exclusive remedy for any fees you may wish to dispute.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.