Palynziq Patient assistance program
Complete a free online enrollment application to find out if you’re eligible to pay only $49 per month for your Palynziq medication with our help.Get started today
- Secure: Your personal and medical information is safe with us
- Convenient: We manage the whole process and we’re here to assist you
- Ongoing refills: We request your medication refills on your behalf
NiceRx works with your healthcare provider to help you access affordable medications directly from U.S. pharmaceutical companies.
An introduction to NiceRx(01:52)
Next steps after qualifying(00:38)
Uploading documents and billing(00:50)
SSN & billing information(00:33)
Medication delivery time(00:41)
How it works
Get started by filling out the online enrollment application to find out if you are eligible.
NiceRx verifies your eligibility for medication assistance and notifies you if you are qualified. The pharmaceutical company provides your medication for free and you only pay our service fee.
You may be required to submit further information and documents required by the pharmaceutical company which can be securely uploaded online.
Your application is created and sent to your doctor for signature. At this stage, you will be billed $49 and will not be billed again until you receive your first medication delivery.
Your application is sent to the pharmaceutical company. You will be billed again once you receive your medication. We handle the entire ordering process including requesting ongoing refills.
Your monthly Palynziq cost savings if eligible
If you are eligible for the Palynziq patient assistance program you can receive your medication for free. Our monthly service fee of $49 per medication covers the cost of our services in applying for the program and requesting your ongoing refills on your behalf. If you obtain your Palynziq through NiceRx, you will only pay $49 a month regardless of the retail price of your medication.
Am I eligible for the Palynziq patient assistance program?
You could receive your Palynziq without paying the full retail price if you meet the eligibility criteria for assistance. The eligibility requirements are set by the pharmaceutical companies that are providing assistance programs. At NiceRx, we review each application individually, although the main factors considered by most programs are:
- I am a permanent, legal resident of the United States or Puerto Rico
- I am uninsured or my insurance doesn’t cover my medication
- I meet certain income eligibility requirements
How do I apply for Palynziq patient assistance?
We do everything that we can to take the hassle and stress out of applying for patient assistance programs. Simply start by filling in our enrollment application. We will ask for details about your healthcare provider, your insurance, and your household income. This information is required by the pharmaceutical companies you are applying to for assistance. We may also be able to help you access patient assistance for other medications that you have been prescribed, so be sure to tell us about any medications you are taking as well as Palynziq.
NiceRx will review the information you have provided, and if we determine that you may be eligible for assistance, we will seek to enroll you in the Palynziq patient assistance program. We will handle the enrollment process for you by working with your healthcare provider and preparing all the required paperwork for your doctor to sign. We will also request your Palynziq medication refills on your behalf for up to 1 year once you are enrolled in the program.
Is NiceRx a Palynziq coupons provider?
At NiceRx, we help eligible individuals access the Palynziq patient assistance program. This means that we are not a Palynziq coupon, a Palynziq discount card, or a Palynziq copay card provider. We do not offer any medication trial offers or free Palynziq samples.
Can NiceRx help me get Palynziq if I have insurance?
We may be able to help you if you have insurance, including if your insurance company will not pay for your Palynziq medication, or you have a high copay or coinsurance responsibility. We may even be able to assist if you do not have insurance. Please fill in our enrollment application to find out more.
How much does Palynziq cost without insurance?
Palynziq costs without insurance will vary depending on how much you buy and the retailer you buy it from. As a guide, Palynziq subcutaneous solution (20 mg/mL) will typically cost around $565 for a supply of 1 milliliter. If you obtain your medication through NiceRx, you will pay a flat monthly rate of $49 per medication regardless of its retail price.
How much does Palynziq cost with insurance?
The copay of Palynziq will vary in line with the specific terms of your healthcare plan. For further details about what you may need to pay, your insurance provider or pharmacist will be able to calculate the copay costs with your current insurance.
What is Palynziq?
Palynziq is an FDA (U.S. Food and Drug Administration) approved medication manufactured by BioMarin Pharmaceutical Inc. Palynziq is a phenylalanine-metabolizing enzyme used to reduce blood phenylalanine concentrations in adult patients with phenylketonuria (PKU), who have uncontrolled blood phenylalanine concentrations greater than 600 micromol/L on existing management.
Palynziq is a novel enzyme substitution therapy that helps meet an unmet need in PKU patients who have been unable to control their blood Phe levels with current treatment options. Patients with PKU are unable to break down phenylalanine (Phe), an amino acid present in protein-containing foods and high-intensity sweeteners used in a range of foods and drinks.
Risk of Anaphylaxis – see the full prescribing information for complete boxed warning. Anaphylaxis has been reported after administration of Palynziq and may occur at any time during treatment. Administer the initial dose of Palynziq under the supervision of a healthcare provider equipped to manage anaphylaxis, and closely observe patients for at least 60 minutes following injection. Prior to self-injection, confirm patient competency with self-administration, and patient’s and observer’s ability to recognize signs and symptoms of anaphylaxis and to administer auto-injectable epinephrine, if needed. Prescribe auto-injectable epinephrine. Prior to the first dose, instruct the patient and observer on its appropriate use. Instruct the patient to seek immediate medical care upon its use. Instruct patients to carry auto-injectable epinephrine with them at all times during treatment. Palynziq is available only through a restricted program called the Palynziq REMS Program.
What doses of Palynziq are available?
Palynziq is available in injection form, in the following doses: 2.5 mg/0.5 mL, 10 mg/0.5 mL, and 20 mg/mL in a single-dose prefilled syringe.
Before starting treatment obtain baseline blood phenylalanine concentration. The recommended initial dose is 2.5 mg subcutaneous injection once weekly for 4 weeks. Increase the dosage in steps over at least 5 weeks based on tolerability to achieve a dosage of 20 mg subcutaneously once daily. See the full prescribing information for the titration regimen.
Consider increasing the dosage to a maximum of 40 mg subcutaneously once daily in patients who have been on 20 mg once daily continuously for at least 24 weeks and who have not achieved either a 20% reduction in blood phenylalanine concentration from pre-treatment baseline or a blood phenylalanine concentration less than or equal to 600 micro mol/L.
Stop treatment in patients who have not achieved at least a 20% reduction in blood phenylalanine concentration from pre-treatment baseline or a blood phenylalanine concentration less than or equal to 600 μmol/L after 16 weeks of continuous treatment with the maximum dosage of 40 mg once daily.
Reduce the dosage and/or modify dietary protein and phenylalanine intake, as needed, to maintain blood phenylalanine concentrations within a clinically acceptable range and above 30 micromol/L.
Obtain blood phenylalanine concentrations every 4 weeks until a maintenance dosage is reached. After a maintenance dosage is established, monitor blood phenylalanine concentrations. Advise patients to monitor dietary protein and phenylalanine intake, and adjust as directed by their healthcare provider.
Always speak with your healthcare provider about any changes to your dose so they can monitor and evaluate your condition.
Palynziq active ingredients
Pegvaliase-pqpz is a PEGylated phenylalanine ammonia-lyase (PAL) enzyme that converts phenylalanine to ammonia and trans-cinnamic acid. It substitutes for the deficient phenylalanine hydroxylase enzyme activity in patients with PKU and reduces blood phenylalanine concentrations.
Palynziq side effects
The most common side effects of Palynziq in clinical trials relative to placebo include:
- Injection site reactions
- Arthralgia (joint pain), headache
- Generalized skin reactions lasting at least 14 days
- Nausea, vomiting
- Abdominal pain, diarrhea
- Throat pain, cough
In rare instances, Palynziq can cause more serious adverse reactions. These can include:
- Hypersensitivity reactions – likely due to the formation of antibodies to the product
Your doctor will assess the benefits of using Palynziq against your risk of adverse events. Patients are encouraged to report negative side effects or adverse reactions of Palynziq to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Palynziq drug interactions
Palynziq can interact with other medications. These include:
- Other PEGylated products
This list is not exhaustive and other drugs may interact with Palynziq. Tell your prescriber about all the medicines you take, including all prescription drugs and non-prescription medicines such as over-the-counter medicines, supplements, or herbal remedies.
You should not use Palynziq if you:
- Are allergic to the active ingredient pegvaliase-pqpz
- Are allergic to any of the other ingredients in Palynziq
- Are younger than 18 years old
Talk to your doctor before using Palynziq if you:
- Are taking any of the medications that could interact with Palynziq
- Are pregnant or are planning to become pregnant – may cause fetal harm
- Are breastfeeding or are planning to breastfeed
Palynziq is the trademark brand name for pegvaliase-pqpz manufactured by BioMarin Pharmaceutical Inc. A generic version of pegvaliase-pqpz is available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Palynziq savings through NiceRx.
*Qualifying persons may obtain medications directly from patient assistance programs without any out-of-pocket cost (or for less than $49 per medication). However, our monthly flat rate of just $49 per medication spares you the hassle of tracking down the different programs and filling out all the required paperwork for each program.
Enrollees enjoy a full-service solution, as NiceRx assists them and their physicians with the entire process. We prepare all required documents for the physician to sign, help enrollees manage all prescription refills, monitor eligibility criteria, and maintain enrollment.
**If you do not receive medications because you were determined to be ineligible for the prescription assistance by the applicable pharmaceutical companies and you have a letter of denial, we will refund any fees you paid toward medications for which you did not qualify to receive prescription assistance (“Refund”).
To receive a refund, you must send the letter of denial to us by fax to 888-517-7444, or by e-mail to [email protected] within 30 days of your receipt of such letter. The Refund is your sole and exclusive remedy for any fees you may wish to dispute.
The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.