Pepaxto Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Is NiceRx a Pepaxto coupon provider?

NiceRx is not a Pepaxto coupon, Pepaxto discount card, or Pepaxto copay card provider. We do not offer Pepaxto manufacturer coupons, Pepaxto discounts, rebates, Pepaxto savings cards, trial offers, or free Pepaxto samples. We are a service provider that helps eligible individuals access their medication directly from the U.S. pharmaceutical company.

Pepaxto patient assistance program

Patient assistance programs are typically sponsored by pharmaceutical companies and provide free or discounted medications to individuals with low income who are uninsured or under-insured and meet the eligibility criteria that vary by program. There are currently no known patient assistance programs for this medication.

Can NiceRx help me get Pepaxto cheaper if I have insurance?

How much does Pepaxto cost without insurance?

Without insurance, Pepaxto costs will vary depending on where you buy the medication as prices will vary by retailer. As a guide, Pepaxto intravenous powder for injection of 20 mg will cost around $10,000 for 1 powder for injection.

How much does Pepaxto cost with insurance?

The copay for Pepaxto will depend on the terms of your healthcare plan. Your healthcare provider or pharmacist will be able to calculate your copay with your current insurance. Contact them to find out more.

What is Pepaxto?

Pepaxto is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Oncopeptides AB. It is classed as an alkylating agent and used with dexamethasone, for the treatment of adult patients with relapsed or refractory multiple myeloma (RRMM) who have already had at least four prior lines of therapy and whose disease is refractory to at least one proteasome inhibitor, one immunomodulatory agent, and one CD38-directed monoclonal antibody.

This indication is approved under accelerated approval based on data from the Horizon study, a multicenter, single-arm trial to determine the safety and efficacy of Pepaxto in patients with RRMM. Continued approval may depend upon verification and description of clinical benefits in confirmatory trials.

What doses of Pepaxto are available?

Pepaxto is available in injection form, in the following doses: 20 mg melphalan flufenamide as a lyophilized powder in a single-dose vial.

Always speak with a healthcare professional about any changes to your dose so they can monitor and evaluate your condition.

Pepaxto active ingredients

The active ingredient of Pepaxto is melphalan flufenamide (also known as melflufen).

Pepaxto side effects

The most common side effects of Pepaxto in clinical trials include:

  • Fatigue
  • Nausea
  • Diarrhea
  • Pyrexia
  • Respiratory tract infection
  • Laboratory abnormalities – decreased leukocytes, platelets, lymphocytes, neutrophils, and hemoglobin
  • Increased creatinine

In rare instances, Pepaxto can cause more serious side effects. These can include:

  • Increased risk of death at doses higher than recommended
  • Thrombocytopenia
  • Neutropenia
  • Anemia
  • Infections
  • Secondary malignancies
  • Embryo-fetal toxicity

Your doctor will assess the benefits of using Pepaxto against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Pepaxto to the FDA. Visit, or call 1-800-FDA-1088.

Pepaxto drug interactions

Other drugs may interact with Pepaxto, including prescription drugs and over-the-counter medicines, vitamins, and herbal products. Tell your health care provider about all of your medications including any supplements you are taking.

Pepaxto contraindications

You should not use Pepaxto if you:

  • Are allergic to the active ingredient melphalan flufenamide
  • Are allergic to any of the other ingredients in Pepaxto
  • Are breastfeeding or are planning to breastfeed

Talk to your doctor before using Pepaxto if you:

  • Are taking any of the medications that could interact with Pepaxto
  • Are pregnant or are planning to become pregnant

Pepaxto generic

Pepaxto is the trademark brand name for melphalan flufenamide manufactured by Oncopeptides Inc. A generic version of melphalan flufenamide is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Pepaxto savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.