Prograf Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Is NiceRx a Prograf coupon provider?

NiceRx does not provide Prograf coupons, discount cards or copay cards. We do not offer printable Prograf manufacturer coupons, Prograf discounts, rebates, Prograf savings cards, trial offers, or free samples. We are a service provider that helps eligible individuals access patient assistance programs.

Prograf patient assistance program

Patient assistance programs are typically sponsored by pharmaceutical companies and provide free or discounted medications to individuals with low income who are uninsured or under-insured and meet the eligibility criteria that vary by program. There are currently no known patient assistance programs for this medication.

How much does Prograf cost without insurance?

Prograf prices without insurance will vary by retailer. As a guide, Prograf intravenous solution (5 mg/mL) will typically cost around $2,400 for 10 milliliters.

How much does Prograf cost with insurance?

Your individual healthcare plan will determine the copay of Prograf with insurance. To find out what you will need to pay, contact your pharmacist or insurance provider. They will be able to calculate your copay with your current insurance.

What is Prograf?

Prograf is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Astellas Pharma US, Inc. Prograf prevents the rejection of transplanted organs by suppressing your immune system. It is classed as a calcineurin-inhibitor immunosuppressant for the prevention of organ rejection in transplant patients receiving allogeneic liver, kidney, or heart transplants. It may be used in combination with corticosteroids, azathioprine, or mycophenolate mofetil. Prograf is not used in combination with cyclosporine, or with sirolimus in liver, heart, or kidney transplants.

What doses of Prograf are available?

Prograf is available in capsule, granules for oral suspension, or in injection form for intravenous use.

Only doctors experienced in immunosuppressive therapy and management of organ transplant patients should prescribe Prograf.

The injection is given to you not long after your transplant until you are ready to take the pill form. Take Prograf at the same time each day, with or without food, with a full glass of water. Prograf oral granules must be mixed with water right before you take them.

Prograf may increase your risk of skin cancer. Limit your time in the sun. Avoid ultraviolet light from tanning booths and sunlamps and use sunscreen and wear protective clothing when outdoors.

Store Prograf at room temperature away from moisture and heat. Read the full patient information provided and always speak with your healthcare provider about any changes to your dose so they can monitor and evaluate your condition.

Prograf active ingredients

Prograf contains tacrolimus as the active ingredient.

Prograf side effects

The most common side effects of Prograf in clinical trials include:

  • Increased risk of infection
  • Nausea, diarrhea, constipation, stomach pain, loss of appetite
  • Weakness, headache
  • Cough, trouble breathing, shortness of breath
  • High blood sugar
  • Low levels of magnesium or phosphate
  • Trouble sleeping
  • High blood pressure

In rare instances, Prograf can cause more serious adverse effects. These can include:

  • Increased risk of development of lymphoma and other malignancies including post transplant lymphoproliferative disorder (PLTD)
  • Serious infections
  • Kidney problems – swelling, urination less, feeling tired or short of breath
  • High potassium levels – nausea, weakness, chest pain, irregular heartbeats, loss of movement
  • QT prolongation – irregular heartbeat, dizziness, and fainting
  • Polyoma virus infections
  • Cytomegalovirus (CMV) infections
  • New-onset diabetes after transplant – African American and Hispanic patients have a higher risk of developing diabetes during their treatment
  • Nephrotoxicity
  • Neurotoxicity
  • Anaphylactic reactions with IV formulation
  • Myocardial hypertrophy
  • Pure red cell aplasia

Your doctor will assess the benefits of using Prograf against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Prograf to the FDA. Visit, or call 1-800-FDA-1088.

Prograf drug interactions

Prograf can interact with other medications. These include:

  • Aluminum and magnesium antacids
  • Other drugs that weaken the immune system and increase the risk of infection such as natalizumab, and rituximab
  • Cimetidine, danazol, nefazodone, ethinyl estradiol, methylprednisolone, St. John’s wort
  • Azole antifungals such as itraconazole, ketoconazole, voriconazole
  • HIV and HCV protease inhibitors such as nelfinavir, ritonavir, boceprevir, telaprevir
  • Rifamycins such as rifampin, and rifabutin
  • Certain anti-seizure drugs such as phenobarbital, phenytoin
  • Live vaccines
  • Grapefruit Juice

This list is not exhaustive and other prescription drugs may interact with Prograf. Tell your healthcare provider about all the medicines you are taking including prescription medicines and nonprescription medicines, natural or herbal remedies, nutritional supplements, and vitamins.

Prograf contraindications

You should not use Prograf if you:

  • Are allergic to the active ingredient tacrolimus
  • Are allergic to any of the other ingredients in Prograf
  • Are pregnant or are planning to become pregnant

Talk to your doctor before using Prograf if you:

  • Are taking any of the medications that could interact with Prograf
  • Have hepatic or renal impairment
  • Are breastfeeding or are planning to breastfeed

Prograf generic

Prograf is the trademark brand name for tacrolimus manufactured by Astellas Pharma US, Inc. A generic version of tacrolimus is available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Prograf savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.