Protonix Coupon & Prices

Is your Protonix medication too expensive?

Get notified when Protonix medication becomes available.

Get Started Now
Medically reviewed by  Jamie Winn, PharmD

Is NiceRx a Protonix coupon provider?

At NiceRx, we help eligible individuals access the Protonix patient assistance program. This means that we are not a Protonix coupon, a Protonix discount card, or a Protonix copay card provider. We do not offer any medication trial offers, or free Protonix samples.

Protonix patient assistance program

Patient assistance programs are typically sponsored by pharmaceutical companies and provide free or discounted medications to individuals with low income who are uninsured or under-insured and meet the eligibility criteria that vary by program. There are currently no known patient assistance programs for this medication.

Can NiceRx help me get Protonix cheaper if I have insurance?

We may be able to help you if you have insurance, including if your insurance company will not pay for your Protonix medication, or if you have a high copay or coinsurance responsibility. We may even be able to assist if you do not have insurance. Please fill in our enrollment application to find out more.

How much does Protonix cost without insurance?

Protonix costs without insurance will vary depending on how much you buy and the retailer you buy it from. As a guide, Protonix oral delayed-release tablet 20 mg will typically cost around $1,600 for 90 tablets.

How much does Protonix cost with insurance?

The copay of Protonix will vary in line with the specific terms of your healthcare plan. For further details about what you may need to pay, your insurance provider or pharmacist will be able to calculate the copay costs with your current insurance.

What is Protonix?

Protonix is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Pfizer. Protonix is a proton pump inhibitor (PPI) used for the:

  • Short-term treatment of erosive esophagitis (damage to the esophagus from stomach acid reflux caused by gastroesophageal reflux disease (GERD/heartburn))
  • Maintenance of healing of erosive esophagitis
  • Pathological hypersecretory conditions including Zollinger Ellison Syndrome

Antacids may be taken in combination with this medication.

What doses of Protonix are available?

Protonix is available as delayed-release tablets, 20 mg, and 40 mg, or as delayed-release granules in packets for preparation of oral suspension, 40 mg.

Please read the prescribing information and medication guide provided and always speak with a healthcare professional for medical advice about any changes to your dose so they can monitor and evaluate your condition.

Protonix active ingredients

Protonix contains pantoprazole sodium as the active ingredient.

Protonix side effects

The most common side effects of Protonix in clinical trials include:

  • Headache, dizziness
  • Nausea
  • Abdominal pain, vomiting, diarrhea, flatulence
  • Joint pain
  • Fever
  • Stomach pain
  • Rash

In rare instances, Protonix can cause more serious side effects. These can include:

  • Atrophic gastritis
  • Bone fracture and increased risk for osteoporosis-related fractures of the hip, wrist, or spine from long-term use
  • Hypomagnesemia
  • Vitamin B-12 deficiency

Your doctor will assess the benefits of using Protonix against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Protonix to the FDA. Visit, or call 1-800-FDA-1088.

Protonix drug interactions

Protonix can interact with other medications. These include:

  • Atazanavir or nelfinavir
  • Warfarin
  • Methotrexate
  • Rilpivirine
  • Certain azole antifungals – itraconazole, ketoconazole, posaconazole

This list is not exhaustive and other prescription drugs may interact with Protonix. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter (OTC) medicines, vitamins, and herbal supplements. Especially tell your doctor if you take methotrexate, digoxin, or a diuretic.

Protonix contraindications

You should not use Protonix if you:

  • Are allergic to pantoprazole or lansoprazole, or omeprazole
  • Have had breathing problems, kidney problems, or a severe allergic reaction after taking pantoprazole in the past
  • Are allergic to any of the other ingredients in Protonix
  • Take rilpivirine
  • Are pregnant or are planning to become pregnant

Talk to your doctor before using Protonix if you:

  • Are taking any of the medications that could interact with Protonix
  • Have low magnesium levels in your blood – monitor magnesium and calcium levels prior to treatment
  • Have systemic lupus erythematosus
  • Have osteoporosis or low bone mineral density
  • Are breastfeeding or are planning to breastfeed – This medication passes into breast milk

Protonix generic

Protonix is the trademark brand name for pantoprazole manufactured by Pfizer. A generic version of pantoprazole is available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Protonix savings through NiceRx.

Related medications

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.