Pylera Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Pylera cost savings if eligible

The Pylera patient assistance program can provide your medication for free. We simply charge $49 a month per medication to cover the cost of our services. With NiceRx, you will only pay $49 to obtain your Pylera, regardless of the retail price.

StrengthAvg. monthly price at
a US pharmacy
NiceRx monthly
Monthly savings
with NiceRx
140/125/125mg - 120 capsules$850.00$49.00$801.00

Am I eligible for the Pylera patient assistance program?

To find out if you are eligible for Pylera assistance you can apply online using our enrollment application. Each pharmaceutical company sets its eligibility criteria, and we will review your application individually to determine if you may be eligible. The three main factors to consider are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Pylera patient assistance program?

Our application process aims to make it as easy as possible to apply for the Pylera patient assistance program. The first step is to complete our online enrollment application. We will ask you for details about your healthcare provider, your insurance plan, and your household income as this information is required by the pharmaceutical companies. We may be able to help you apply for other patient assistance programs too, so be sure to tell us about any medications you are taking as well as Pylera.

NiceRx will review your application and determine whether you may be eligible for Pylera assistance. If so, we will handle the full enrollment process for you and prepare all required documents for your healthcare provider to sign. Once you are successfully enrolled in the Pylera patient assistance program, we will help you manage your prescription refills by requesting refills on your behalf throughout your enrollment period. At the end of your enrollment period we will contact you for updated information and seek to re-enroll you so you can continue to access affordable Pylera.

Is NiceRx a Pylera coupons provider?

NiceRx is a service provider that helps eligible individuals access the Pylera patient assistance program. We do not offer trial offers or free Pylera samples. When obtaining your medication through NiceRx, you will only pay $49 a month per medication. This will likely save you more money than if you were to use Pylera coupons, discount cards, or Pylera copay cards.

Can NiceRx help me get Pylera if I have insurance?

NiceRx may be able to help you if your insurance company will not pay for your Pylera medication. We may also be able to help if you have a high copay or coinsurance responsibility. Whether you have insurance or not, apply online using our enrollment application to find out more.

How much is Pylera with insurance?

The cost of Pylera will vary by the terms of your healthcare plan. To find out what you might need to pay for Pylera with insurance, your insurance provider or pharmacist will be able to help you calculate the copay costs with your current insurance.

How much does Pylera cost without insurance?

Pylera prices without insurance will vary depending on where you buy it. As a guide, Pylera oral capsule (140 mg-125 mg-125 mg) typically costs $972 for a supply of 120 capsules.

What is Pylera?

Pylera is a prescription medicine used with omeprazole to treat Helicobacter pylori infection in patients with duodenal ulcers or a history of duodenal ulcer disease. Treating the Helicobacter pylori infection reduces the risk of duodenal ulcer recurring.

Pylera should be used to treat those infections only that are strongly suspected to be caused by the susceptible infection. This is to reduce drug-resistant bacteria developing and to ensure the effectiveness of Pylera.

Pylera active ingredients

Pylera contains a combination of bismuth subcitrate potassium, metronidazole, and tetracycline. Bismuth subcitrate potassium is a mineral. Metronidazole is an antibiotic that works well against anaerobic bacteria (bacteria not requiring oxygen to grow), and tetracycline, which is classed as a broad spectrum antibiotic that fights bacteria in the body by blocking the production of their protiens. The combined effect of the ingredients in Pylera together with omeprazole has been found to be more effective in the eradication of th H. pylori infection.

Pylera side effects

The most common side effects caused by Pylera include:

  • tongue darker in color, dry mouth
  • diarrhea
  • dark or black stools
  • nausea (feeling sick)
  • headache

In rare cases Pylera can cause more serious side effects, these can include:

  • Liver problems – yallowing of eyes or skin, stomach pain, nausea, darker stools
  • Flu symptoms – fever, chills, sore throat
  • severe headaches, dizziness, nausea, eye pain, vision problems, ringing in your ears
  • watery or bloody diarrhea
  • stiff neck, light sensitivity, purple spots on the skin
  • tingling or numbness in arms and legs
  • seizures

Pylera drug interactions

Pylera can interact with other medications, these include:

  • acitretin, etretinate
  • busulfan
  • cholera vaccine, typhoid vaccine
  • disulfiram
  • isotretinoin, tretinoin
  • methoxyflurane
  • warfarin, dicumarol

This list is not exhaustive and other drugs may interact with Pylera.

Pylera warnings and precautions

You should not take Pylera if you:

  • Are allergic to the active ingredients bismuth subcitrate potassium, metronidazole, or tetracycline.
  • Are allergic to any of the other ingredients in Pylera
  • Have any kidney problems
  • Drink alcohol daily
  • Have taken disulfiram within the past 2 weeks
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed
  • Are under 18 years of age

You should avoid taking Pylera with milk or other dairy products. Also avoid taking the medicine at the same time you take any multivitamins, mineral supplements, or antacids. These products make it more difficult for your body to absorb Pylera.

Talk to your doctor before taking Pylera if you:

  • Are taking any of the medications that could interact with Pylera
  • Take any medicine that contains propylene glycol.
  • Have any liver problems
  • Have Cockayne syndrome (a rare genetic disorder)
  • Have a blood cell disorder
  • Have an infection of any type

Related medications

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.