Pyrukynd Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Pyrukynd cost savings if eligible

If you are eligible for the Pyrukynd patient assistance program you can receive your medication for free. Our monthly service fee of $49 per medication covers the cost of our services in applying for the program and requesting your ongoing refills on your behalf. If you obtain your Pyrukynd through NiceRx, you will only pay $49 a month regardless of the retail price of your medication.

Am I eligible for the Pyrukynd patient assistance program?

You could receive your Pyrukynd without paying the full retail price if you meet the eligibility criteria for assistance. The eligibility requirements are set by the pharmaceutical companies that are providing assistance programs. At NiceRx, we review each application individually, although the main factors considered by most programs are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for Pyrukynd patient assistance?

We do everything that we can to take the hassle and stress out of applying for patient assistance programs. Simply start by filling in our enrollment application. We will ask for details about your healthcare provider, your insurance, and your household income. This information is required by the pharmaceutical companies you are applying to for assistance. We may also be able to help you access patient assistance for other medications that you have been prescribed, so be sure to tell us about any medications you are taking as well as Pyrukynd.

NiceRx will review the information you have provided, and if we determine that you may be eligible for assistance, we will seek to enroll you in the Pyrukynd patient assistance program. We will handle the enrollment process for you by working with your healthcare provider and preparing all the required paperwork for your doctor to sign. We will also request your Pyrukynd medication refills on your behalf for up to 1 year once you are enrolled in the program.

Is NiceRx a Pyrukynd coupon provider?

At NiceRx, we help eligible individuals access the Pyrukynd patient assistance program. This means that we are not a Pyrukynd coupon, a Pyrukynd discount card, or a Pyrukynd copay card provider. We do not offer any medication trial offers, or free Pyrukynd samples.

Can NiceRx help me get Pyrukynd cheaper if I have insurance?

We may be able to help you if you have insurance, including if your insurance company will not pay for your Pyrukynd medication, or if you have a high copay or coinsurance responsibility. We may even be able to assist if you do not have insurance. Please fill in our enrollment application to find out more.

How much does Pyrukynd cost without insurance?

Pyrukynd costs without insurance will vary depending on how much you buy and the retailer you buy it from. As a guide, Pyrukynd will typically cost around $335,000 annually. If you obtain your medication through NiceRx, you will pay a flat monthly rate of $49 per medication regardless of its retail price.

How much does Pyrukynd cost with insurance?

The copay of Pyrukynd will vary in line with the specific terms of your healthcare plan. For further details about what you may need to pay, your insurance provider or pharmacist will be able to calculate the copay costs with your current insurance.

What is Pyrukynd?

Pyrukynd is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Agios Pharmaceuticals, Inc. The FDA has granted orphan drug designation to Pyrukynd in PK deficiency. FDA approval of Pyrukynd was based on the ACTIVATE study that found that 40% more patients taking Pyrukynd had increased hemoglobin compared to those taking placebo. In the ACTIVATE-T study, 33% of patients taking Pyrukynd saw a reduction in the need for blood transfusions.

Pyrukynd is a pyruvate kinase activator used for the treatment of hemolytic anemia (a condition in which red blood cells are destroyed faster than they can be made) in adults with pyruvate kinase deficiency. It works by slowing the breakdown of red blood cells and may help to improve symptoms of anemia such as shortness of breath, tiredness, and a decrease in the need for blood transfusions.

What doses of Pyrukynd are available?

Pyrukynd is available in tablet form, in the following doses: 5 mg, 20 mg, and 50 mg.

The starting dose for Pyrukynd is 5 mg orally twice daily with or without food. Swallow the tablets whole. Do not crush, chew or break the tablets. See the full prescribing information for dose titration and taper schedule.

Always speak with a healthcare professional about any changes to your dose so they can monitor and evaluate your condition.

Pyrukynd active ingredients

Pyrukynd contains mitapivat as the active ingredient.

Pyrukynd side effects

The most common side effects of Pyrukynd in clinical trials include:

  • Decreased estrone and estradiol
  • Increased urate
  • Back pain
  • Arthralgia

In rare instances, Pyrukynd can cause more serious side effects. These can include:

  • Rapid breakdown of red blood cells (acute hemolysis) after suddenly interrupting or stopping treatment. Symptoms of the breakdown of red blood cells include yellowing of the skin or the whites of your eyes (jaundice), dark colored urine, dizziness, tiredness, confusion, shortness of breath

Your doctor will assess the benefits of using Pyrukynd against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Pyrukynd to the FDA. Visit, or call 1-800-FDA-1088.

Pyrukynd drug interactions

Pyrukynd can interact with other medications. These include:

  • Strong CYP3A inhibitors and inducers
  • Moderate CYP3A inhibitors
  • Moderate CYP3A inducers
  • Sensitive CYP3A, CYP2B6, and CYP2C substrates including hormonal contraceptives
  • UGT1A1 substrates
  • P-gp substrates

This list is not exhaustive and other prescription drugs may interact with Pyrukynd. Tell your healthcare provider about all the medicines that you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Pyrukynd contraindications

You should not use Pyrukynd if you:

  • Are allergic to the active ingredient mitapivat
  • Are allergic to any of the other ingredients in Pyrukynd
  • Have hepatic impairment

Talk to your doctor before using Pyrukynd if you:

  • Are taking any of the medications that could interact with Pyrukynd
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed

Pyrukynd generic

Pyrukynd is the trademark brand name for mitapivat manufactured by Agios Pharmaceuticals, Inc. A generic version of mitapivat is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Pyrukynd savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.