Rayaldee Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Rayaldee cost savings if eligible

If you are eligible for the Rayaldee patient assistance program you can receive your medication for free. Our monthly service fee of $49 per medication covers the cost of our services in applying for the program and requesting your ongoing refills on your behalf. If you obtain your Rayaldee through NiceRx, you will only pay $49 a month regardless of the retail price of your medication.

Am I eligible for the Rayaldee patient assistance program?

You could receive your Rayaldee without paying the full retail price if you meet the eligibility criteria for assistance. The eligibility requirements are set by the pharmaceutical companies that are providing assistance programs. At NiceRx, we review each application individually, although the main factors considered by most programs are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for Rayaldee patient assistance?

We do everything that we can to take the hassle and stress out of applying for patient assistance programs. Simply start by filling in our enrollment application. We will ask for details about your healthcare provider, your insurance, and your household income. This information is required by the pharmaceutical companies you are applying to for assistance. We may also be able to help you access patient assistance for other medications that you have been prescribed, so be sure to tell us about any medications you are taking as well as Rayaldee.

NiceRx will review the information you have provided, and if we determine that you may be eligible for assistance, we will seek to enroll you in the Rayaldee patient assistance program. We will handle the enrollment process for you by working with your healthcare provider and preparing all the required paperwork for your doctor to sign. We will also request your Rayaldee medication refills on your behalf for up to 1 year once you are enrolled in the program.

Is NiceRx a Rayaldee coupons provider?

At NiceRx, we help eligible individuals access the Rayaldee patient assistance program. This means that we are not a Rayaldee coupon, a Rayaldee discount card, or a Rayaldee copay card provider. We do not offer any medication trial offers, or free Rayaldee samples.

Can NiceRx help me get Rayaldee if I have insurance?

We may be able to help you if you have insurance, including if your insurance company will not pay for your Rayaldee medication, or you have a high copay or coinsurance responsibility. We may even be able to assist if you do not have insurance. Please fill in our enrollment application to find out more.

How much does Rayaldee cost without insurance?

Rayaldee costs without insurance will vary depending on how much you buy and the retailer you buy it from. As a guide, Rayaldee oral capsules, extended-release 30 mcg will typically cost around $1,200 for 30 capsules. If you obtain your medication through NiceRx, you will pay a flat monthly rate of $49 per medication regardless of its retail price.

How much does Rayaldee cost with insurance?

The copay of Rayaldee will vary in line with the specific terms of your healthcare plan. For further details about what you may need to pay, your insurance provider or pharmacist will be able to calculate the copay costs with your current insurance.

What is Rayaldee?

Rayaldee is an FDA (U.S. Food and Drug Administration) approved medication manufactured by OPKO Pharmaceuticals, LLC. It is a vitamin D3 analog indicated for the treatment of secondary hyperparathyroidism in adults with stage 3 or 4 chronic kidney disease (CKD) and serum total 25-hydroxyvitamin D levels less than 30 ng/mL. It is not indicated for use in patients with stage 5 chronic kidney disease or end-stage renal disease on dialysis.

What doses of Rayaldee are available?

Rayaldee is available in extended-release capsule form, in the following doses: 30mcg

The initial dose is 30 mcg taken orally once daily at bedtime. Swallow the capsules whole. Do not crush or chew the capsules.

Serum calcium should be below 9.8 mg/dL before commencing treatment. Monitor serum calcium, phosphorus, 25-hydroxyvitamin D, and intact parathyroid hormone (PTH) 3 months after starting therapy or changing dose. Increase the dose to 60 mcg once daily after 3 months if intact PTH is above the treatment goal. Suspend dosing if intact PTH is persistently abnormally low, serum calcium is consistently above the normal range or serum 25­ hydroxyvitamin D is consistently above 100 ng/mL.

Always speak with your healthcare provider about any changes to your dose so they can monitor and evaluate your condition.

Rayaldee active ingredients

Calcifediol is a prohormone of the active form of vitamin D3, calcitriol. It is converted to calcitriol by cytochrome P450 27B1, also called 1-alpha hydroxylase, primarily in the kidney. Calcitriol attaches to the vitamin D receptor in target tissues and activates vitamin D responsive pathways that result in increased intestinal absorption of calcium and phosphorus and reduced parathyroid hormone production.

Rayaldee side effects

The most common side effects of Rayaldee in clinical trials compared to placebo include:

  • Anemia
  • Nasopharyngitis
  • Increased blood creatinine
  • Dyspnea
  • Congestive heart failure
  • Constipation

In rare instances, Rayaldee can cause more serious side effects. These can include:

  • Hypercalcemia (high calcium levels) and hypercalciuria – symptoms include tiredness, difficulty thinking clearly, loss of appetite, nausea, vomiting, constipation, increased thirst, increased urination, weight loss
  • Digitalis toxicity
  • Adynamic bone disease – monitor for abnormally low levels of intact PTH levels when using Rayaldee

Your doctor will assess the benefits of using Rayaldee against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Rayaldee to the FDA. Visit, or call 1-800-FDA-1088.

Rayaldee drug interactions

Rayaldee can interact with other medications. These include:

  • Cytochrome P450 inhibitors such as ketoconazole
  • Thiazides
  • Cholestyramine
  • Drugs stimulating microsomal hydroxylation such as phenobarbital

This list is not exhaustive and other prescription drugs may interact with Rayaldee. Tell your healthcare provider about all the medications you are taking, including other vitamin D medications, or over-the-counter vitamin D supplements.

Rayaldee contraindications

You should not use Rayaldee if you:

  • Are allergic to the active ingredient calcifediol
  • Are allergic to any of the other ingredients in Rayaldee

Talk to your doctor before using Rayaldee if you:

  • Are taking any of the medications that could interact with Rayaldee
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed

Rayaldee generic

Rayaldee is the trademark brand name for calcifediol manufactured by OPKO Pharmaceuticals, LLC. A generic version of calcifediol is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Rayaldee savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.