Rebif Coupon & Prices

Is your Rebif medication too expensive? Start receiving your medication for only $49 per month.*

Complete a free online enrollment application to find out if you’re eligible to pay only $49 per month for your Rebif medication with our help.

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  • NiceRx Benefit
    Secure: Your personal and medical information is safe with us
  • NiceRx Benefit
    Convenient: We manage the whole process and we’re here to assist you
  • NiceRx Benefit
    Ongoing refills: We request your medication refills on your behalf
  • NiceRx Benefit
    Secure: Your personal and medical information is safe with us
  • NiceRx Benefit
    Convenient: We manage the whole process and we’re here to assist you
  • NiceRx Benefit
    Ongoing refills: We request your medication refills on your behalf

NiceRx works with your healthcare provider to help you access affordable medications directly from U.S. pharmaceutical companies.

How it works

  • Enroll online

    Get started by filling out the online enrollment application to find out if you are eligible for assistance.

  • Pre-qualification

    NiceRx verifies your eligibility for medication assistance and notifies you if you are pre-qualified. The pharmaceutical company provides your medication for free, and you only pay our service fee.

  • Submit documents

    We will request documents to be submitted by you and your healthcare provider that are required by the pharmaceutical company to complete your enrollment.

  • Receive medication

    Once approved, the pharmaceutical company typically ships a 90-day supply of medication to your home or healthcare provider’s address. Final acceptance is determined by the pharmaceutical company.

Medically reviewed by  Jamie Winn, PharmD

Your monthly Rebif cost savings if eligible

The Rebif patient assistance program can provide your medication for free. We simply charge $49 per month for each medication to cover the cost of our services. With NiceRx, you will only pay $49 to obtain your Rebif, regardless of the retail price.

Am I eligible for the Rebif patient assistance program?

To find out if you are eligible for Rebif assistance you can apply online using our enrollment application. Each pharmaceutical company sets its eligibility criteria, and we will review your application individually to determine if you may be eligible. The three main factors to consider are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Rebif patient assistance program?

Our application process aims to make it as easy as possible to apply for the Rebif patient assistance program. The first step is to complete our online enrollment application. We will ask you for details about your healthcare provider, your insurance plan, and your household income as this information is required by the pharmaceutical companies. We may be able to help you apply for other patient assistance programs too, so be sure to tell us about any medications you are taking as well as Rebif.

NiceRx will review your application and determine whether you may be eligible for Rebif assistance. If so, we will handle the full enrollment process for you and prepare all required documents for your healthcare provider to sign. Once you are successfully enrolled in the Rebif patient assistance program, we will help you manage your prescription refills by requesting refills on your behalf throughout your enrollment period. At the end of your enrollment period, we will contact you for updated information and seek to re-enroll you so you can continue to access affordable Rebif.

Is NiceRx a Rebif coupons provider?

NiceRx is a service provider that helps eligible individuals access the Rebif patient assistance program. We do not offer trial offers or free Rebif samples. When obtaining your medication through NiceRx, you will only pay $49 a month per medication. This will likely save you more money than if you were to use Rebif coupons, discount cards, or Rebif copay cards.

Can NiceRx help me get Rebif if I have insurance?

NiceRx may be able to help you if your insurance company will not pay for your Rebif medication. We may also be able to help if you have a high copay or coinsurance responsibility. Whether you have insurance or not, apply online using our enrollment application to find out more.

How much does Rebif cost without insurance?

Rebif prices without insurance will vary depending on how much you buy. Prices will also vary by retailer. As a guide, a Rebif subcutaneous kit will typically cost $9,600 for 4.2 milliliters.

How much does Rebif cost with insurance?

The copay for Rebif will vary by the terms of your healthcare plan. To find out what you might need to pay for Rebif with insurance, your insurance provider or pharmacist will be able to help you calculate the copay costs with your current insurance.

What is Rebif?

Rebif is an FDA (U.S. Food and Drug Administration) approved medication manufactured by EMD Serono, Inc. the healthcare business of Merck. Rebif (interferon beta-1a) is made from human proteins. Interferons help your immune system fight viral infections. Rebif was proven superior to Avonex, another interferon beta-1a RMS treatment.

Rebif is indicated for the treatment of relapsing forms of multiple sclerosis (MS), including clinically isolated syndrome, relapsing-remitting disease (RRMS), and active secondary progressive disease, in adults.

What doses of Rebif are available?

Rebif is available in injection form, in the following doses: 8.8 mcg in 0.2 mL, and 22 mcg or 44 mcg in 0.5 mL in a single-dose prefilled syringe. 8.8 mcg in 0.2 mL, and 22 mcg or 44 mcg in 0.5 mL in a single-dose autoinjector

For the subcutaneous injection, only the recommended dose is either 22 mcg or 44 mcg injected subcutaneously three times per week. The starting dose should be 20% of the prescribed dose three times per week, and titrated over a 4 week period to the targeted recommended dose of either 22 mcg or 44 mcg subcutaneously three times per week.

Please read the full medication guide and always speak with a healthcare professional for medical advice or about any changes to your dose so they can monitor and evaluate your condition.

Rebif active ingredients

Rebif contains interferon beta-1a as the active ingredient.

Rebif side effects

The most common side effects of Rebif in clinical trials compared to placebo include:

  • Flu-like symptoms
  • Muscle aches
  • Abdominal pain
  • Depression
  • Elevation of liver enzymes
  • Hematologic abnormalities

In rare instances, Rebif can cause more serious side effects. These can include:

  • Depression and suicide
  • Hepatic injury (liver problems) – monitor liver function tests
  • Anaphylaxis and other allergic reactions
  • Injection site skin reactions including necrosis. If multiple lesions occur, discontinue until healing of skin lesions
  • Decreased peripheral blood counts
  • Thrombotic microangiopathy
  • Seizures – monitor patients, particularly those with pre-existing seizure disorders
  • Changes in your mood or symptoms, report any new or worsening symptoms
  • Interferon-beta-1a can harm your liver, call your doctor if you have symptoms such as nausea, loss of appetite, tiredness, confusion, easy bruising or bleeding, dark urine, clay-colored stools, or yellowing of your skin or eyes

Your doctor will assess the benefits of using Rebif against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Rebif to the FDA. Visit, or call 1-800-FDA-1088.

Rebif drug interactions

Rebif can interact with other medications. These include:

  • Immunosuppressants – fingolimod, siponimod
  • DMARDs – leflunomide, teriflunomide
  • Anticonvulsants – carbamazepine, phenytoin
  • Statins – atorvastatin, pravastatin, simvastatin
  • Blood thinners – warfarin

This list is not exhaustive and other prescription drugs may interact with Rebif. Tell your healthcare provider about all the medicines you take, including prescription drugs and over-the-counter medicines, vitamins, and herbal supplements.

Rebif contraindications

You should not use Rebif if you:

  • Are allergic to the active ingredient interferon beta-1a or human albumin
  • Are allergic to any of the other ingredients in Rebif
  • Are pregnant or are planning to become pregnant

Talk to your doctor before using Rebif if you:

  • Are taking any of the medications that could interact with Rebif
  • Have depression mental illness, or suicidal thoughts or actions
  • Have liver disease
  • Have bleeding problems or a blood clot
  • Have low blood cell counts
  • Have chest pain
  • Have a thyroid disorder
  • Have a latex allergy
  • Have an autoimmune disorder
  • Suffer from seizures
  • Drink alcohol
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed

Rebif generic

Rebif is the trademark brand name for interferon beta-1a manufactured by EMD Serono, Inc. A generic version of interferon beta-1a is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Rebif savings through NiceRx.

Related conditions

*Qualifying persons may obtain medications directly from patient assistance programs without any out-of-pocket cost (or for less than $49 per medication). However, our monthly flat rate of just $49 per medication spares you the hassle of tracking the different programs and filling out all the required paperwork for each program. Subject to medication availability and acceptance by the pharmaceutical companies. NiceRx is not responsible for any delays or rejection by the pharmaceutical companies.

Enrollees enjoy a full-service solution, as NiceRx assists them and their physicians with the entire process. We prepare all required documents for the physician to sign, help enrollees manage all prescription refills, monitor eligibility criteria, and maintain enrollment.

**If you do not receive medications because you were determined to be ineligible for the prescription assistance by the applicable pharmaceutical companies and you have a letter of denial, we will refund any fees you paid toward medications for which you did not qualify to receive prescription assistance (“Refund”).

To receive a refund, you must send the letter of denial to us by fax to 888-517-7444, or by e-mail to [email protected] within 30 days of your receipt of such letter. The Refund is your sole and exclusive remedy for any fees you may wish to dispute.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.