RediTrex Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Is NiceRx a Reditrex coupon provider?

NiceRx is a service provider that helps eligible individuals access the Reditrex patient assistance program. We do not offer trial offers or free Reditrex samples. This will likely save you more money than if you were to use Reditrex coupons, discount cards, or Reditrex copay cards.

Reditrex patient assistance program

Patient assistance programs are typically sponsored by pharmaceutical companies and provide free or discounted medications to individuals with low income who are uninsured or under-insured and meet the eligibility criteria that vary by program. There are currently no known patient assistance programs for this medication.

How much does Reditrex cost without insurance?

Reditrex prices without insurance will vary depending on how much you buy. Prices will also vary by retailer. As a guide, Reditrex subcutaneous solution (7.5 mg/0.3 mL) typically costs $340 for 1.2 milliliters.

How much does Reditrex cost with insurance?

The copay for Reditrex will vary by the terms of your healthcare plan. To find out what you might need to pay for Reditrex with insurance, your insurance provider or pharmacist will be able to help you calculate the copay costs with your current insurance.

What is Reditrex?

Reditrex is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Cumberland Pharmaceuticals Inc. RediTrex is a folate analog metabolic inhibitor used for the:

  • Management of severe, active rheumatoid arthritis (RA) and polyarticular juvenile idiopathic arthritis (pJIA) in patients who are not tolerant of or have had an inadequate response to first-line therapy
  • Control of severe symptoms of psoriasis in adults who are not fully responsive to other therapy

RediTrex is not recommended for the treatment of neoplastic diseases

What doses of Reditrex are available?

Reditrex is available in injection form as single-dose prefilled syringes delivering methotrexate in the following dosage strengths: 7.5mg, 10 mg, 12.5 mg, 15 mg, 17.5 mg, 20 mg, 22.5 mg and 25 mg.

RediTrex is for once weekly subcutaneous administration in the abdomen or thigh. The starting dose of methotrexate for rheumatoid arthritis is 7.5 mg once weekly. For polyarticular juvenile idiopathic arthritis the starting dose is 10 mg/m2 once weekly. For psoriasis the starting dose is 10 to 25 mg once weekly of an oral, intramuscular, subcutaneous, or intravenous formulation. Otrexup (methotrexate subcutaneous injection) and Rasuvo (methotrexate subcutaneous auto-injector) are alternative brands of methotrexate.

You should take a folic acid supplement with methotrexate to prevent folate deficiency. Taking methotrexate can reduce levels of folate in your body. A lack of folate can lead an upset stomach, low blood cell counts, fatigue, muscle weakness, mouth sores, liver toxicity and central nervous system symptoms.

Please see the full prescribing information for the complete boxed warning, and always speak with a healthcare professional for medical advice about any changes to your dose so they can monitor and evaluate your condition.

Reditrex active ingredients

Reditrex contains methotrexate as the active ingredient.

Reditrex side effects

The most common side effects of Reditrex in clinical trials include:

  • Nausea, stomach pain, dyspepsia, diarrhea, vomiting
  • Stomatitis/mouth sores, rash, nasopharyngitis
  • Hair loss
  • Liver function test abnormalities
  • Headache, dizziness
  • Bronchitis
  • Thrombocytopenia, leucopenia, pancytopenia
  • Photosensitivity, and burning of skin lesions

In rare instances, Reditrex can cause more serious side effects. These can include:

  • Serious toxic reactions and death – bone marrow, liver, lung, skin, and kidney toxicities
  • Embryo-fetal toxicity, including fetal death
  • Unexpectedly severe bone marrow suppression, aplastic anemia, and gastrointestinal toxicity when given with some nonsteroidal anti-inflammatory drugs (NSAIDs)
  • Hepatotoxicity, fibrosis, and cirrhosis
  • Interstitial pneumonitis
  • Pulmonary symptoms (especially a dry cough) may require interruption of treatment
  • Diarrhea, ulcerative stomatitis, hemorrhagic enteritis, and death
  • Severe, occasionally fatal, skin reactions
  • Potentially fatal opportunistic infections may occur

Your doctor will assess the benefits of using Reditrex against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Reditrex to the FDA. Visit, or call 1-800-FDA-1088.

Reditrex drug interactions

Reditrex can interact with other medications. These include:

  • NSAIDs – ibuprofen, diclofenac, naproxen
  • Steroids
  • Proton pump inhibitors – omeprazole
  • Certain vaccinations

This list is not exhaustive and other prescription drugs may interact with Reditrex.

Reditrex contraindications

You should not use Reditrex if you:

  • Are allergic to the active ingredient methotrexate
  • Are allergic to any of the other ingredients in Reditrex
  • Suffer from alcoholism
  • Have liver disease or any other liver problems
  • Have immunodeficiency syndromes (weak immune system)
  • Are pregnant or are planning to become pregnant

Talk to your doctor before using Reditrex if you:

  • Are taking any of the medications that could interact with Reditrex
  • Have anemia, leukopenia, or thrombocytopenia (low platelet blood level)
  • Have kidney disease
  • Have pleural effusion
  • Have diabetes or
  • Have ulcerative colitis
  • Are breastfeeding or are planning to breastfeed

Reditrex generic

Reditrex is the trademark brand name for methotrexate manufactured by Cumberland Pharmaceuticals Inc. A generic version of methotrexate is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Reditrex savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.