Rylaze Coupon & Prices

Is your Rylaze medication too expensive? Start receiving your medication for only $49 per month.*

Complete a free online enrollment application to find out if you’re eligible to pay only $49 per month for your Rylaze medication with our help.

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  • NiceRx Benefit
    Secure: Your personal and medical information is safe with us
  • NiceRx Benefit
    Convenient: Your medication is delivered straight to your door
  • NiceRx Benefit
    Ongoing refills: Your medication is refilled automatically
  • NiceRx Benefit
    Secure: Your personal and medical information is safe with us
  • NiceRx Benefit
    Convenient: We manage the whole process and we’re here to assist you
  • NiceRx Benefit
    Ongoing refills: We request your medication refills on your behalf

NiceRx works with your healthcare provider to help you access affordable medications directly from U.S. pharmaceutical companies.

How it works

  • Enroll online

    Get started by filling out the online enrollment application to find out if you are eligible for assistance.

  • Pre-qualification

    NiceRx verifies your eligibility for medication assistance and notifies you if you are pre-qualified. The pharmaceutical company provides your medication for free, and you only pay our service fee.

  • Submit documents

    We will request documents to be submitted by you and your healthcare provider that are required by the pharmaceutical company to complete your enrollment.

  • Receive medication

    Once approved, the pharmaceutical company typically ships a 90-day supply of medication to your home or healthcare provider’s address. Final acceptance is determined by the pharmaceutical company.

Medically reviewed by  Jamie Winn, PharmD

Your monthly Rylaze cost savings if eligible

If you are eligible for the Rylaze patient assistance program you can receive your medication for free. Our monthly service fee of $49 per medication covers the cost of our services in applying for the program and requesting your ongoing refills on your behalf. If you obtain your Rylaze through NiceRx, you will only pay $49 a month regardless of the retail price of your medication.

Am I eligible for the Rylaze patient assistance program?

You could receive your Rylaze without paying the full retail price if you meet the eligibility criteria for assistance. The eligibility requirements are set by the pharmaceutical companies that are providing assistance programs. At NiceRx, we review each application individually, although the main factors considered by most programs are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for Rylaze patient assistance?

We do everything that we can to take the hassle and stress out of applying for patient assistance programs. Simply start by filling in our enrollment application. We will ask for details about your healthcare provider, your insurance, and your household income. This information is required by the pharmaceutical companies you are applying to for assistance. We may also be able to help you access patient assistance for other medications that you have been prescribed, so be sure to tell us about any medications you are taking as well as Rylaze.

NiceRx will review the information you have provided, and if we determine that you may be eligible for assistance, we will seek to enroll you in the Rylaze patient assistance program. We will handle the enrollment process for you by working with your healthcare provider and preparing all the required paperwork for your doctor to sign. We will also request your Rylaze medication refills on your behalf for up to 1 year once you are enrolled in the program.

Is NiceRx a Rylaze coupon provider?

At NiceRx, we help eligible individuals access the Rylaze patient assistance program. This means that we are not a Rylaze coupon, a Rylaze discount card, or a Rylaze copay card provider. We do not offer any medication trial offers, or free Rylaze samples.

Can NiceRx help me get Rylaze cheaper if I have insurance?

We may be able to help you if you have insurance, including if your insurance company will not pay for your Rylaze medication, or you have a high copay or coinsurance responsibility. We may even be able to assist if you do not have insurance. Please fill in our enrollment application to find out more.

How much does Rylaze cost without insurance?

Rylaze costs without insurance will vary depending on how much you buy and the retailer you buy it from. As a guide, Rylaze intramuscular solution (rywn recombinant 10 mg/0.5 mL) will typically cost around $13,900 for 1.5 milliliters. If you obtain your medication through NiceRx, you will pay a flat monthly rate of $49 per medication regardless of its retail price.

How much does Rylaze cost with insurance?

The copay of Rylaze will vary in line with the specific terms of your healthcare plan. For further details about what you may need to pay, your insurance provider or pharmacist will be able to calculate the copay costs with your current insurance.

What is Rylaze?

Rylaze is an asparagine-specific enzyme manufactured by Jazz Pharmaceuticals, Inc. FDA approval of Rylaze (U.S. Food and Drug Administration) is as a component of a multi-agent chemotherapeutic regimen for the treatment of ALL (acute lymphoblastic leukemia) and lymphoblastic lymphoma (LBL) in adult and pediatric patients 1 month or older who have developed hypersensitivity to E. coli-derived asparaginase.

What doses of Rylaze are available?

Rylaze is available in injection form, in the following doses: 10 mg/0.5 mL solution in a single-dose vial.

When replacing a long-acting asparaginase product, the recommended dosage of Rylaze is 25 mg/m2 administered intramuscularly every 48 hours.

Please see the full prescribing information and always speak with your healthcare provider about any changes to your dose so they can monitor and evaluate your condition.

Rylaze active ingredients

Rylaze contains asparaginase erwinia chrysanthemi (recombinant)-rywn (also known as JZP458) as the active ingredient.

Rylaze side effects

The most common side effects of Rylaze in clinical trials (incidence > 20%) include:

  • Nausea
  • Musculoskeletal pain
  • Fatigue
  • Infection
  • Headache
  • Pyrexia
  • Febrile neutropenia
  • Decreased appetite
  • Stomatitis
  • Bleeding
  • Hyperglycemia
  • Hypersensitivity reactions
  • Blood clots
  • Hemorrhage
  • Hepatotoxicity – liver toxicity (abnormal liver tests, increased bilirubin)

In rare instances, Rylaze can cause more serious side effects. These can include:

  • Pancreatitis (abdominal pain)
  • Thrombosis

Your doctor will assess the benefits of using Rylaze against your risk of adverse events. Patients are encouraged to report negative side effects or adverse reactions of Rylaze to the FDA. Visit, or call 1-800-FDA-1088.

Rylaze drug interactions

Other drugs may interact with Rylaze, including prescription drugs and over-the-counter medicines, vitamins, and herbal products. Tell your health care provider about all of your medicines including any supplements you are taking.

Rylaze contraindications

You should not use Rylaze if you:

  • Are allergic to the active ingredient asparaginase erwinia chrysanthemi (recombinant)-rywn
  • Have had an allergic reaction to any of the other ingredients in Rylaze
  • Have had serious hypersensitivity reactions to Rylaze, including anaphylaxis
  • Have had serious pancreatitis during previous L-asparaginase therapy
  • Have had serious thrombosis during previous L-asparaginase therapy
  • Have had serious hemorrhagic events during previous L-asparaginase therapy
  • Are pregnant or are planning to become pregnant – females of reproductive potential are advised to use effective non-hormonal contraceptive methods during treatment and for 3 months after the last dose
  • Are breastfeeding or are planning to breastfeed

Talk to your doctor before using Rylaze if you:

  • Are taking any of the medications that could interact with Rylaze

Rylaze generic

Rylaze is the trademark brand name for asparaginase erwinia chrysanthemi (recombinant)-rywn manufactured by Jazz Pharmaceuticals, Inc. A generic version of asparaginase erwinia chrysanthemi (recombinant)-rywn is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Rylaze savings through NiceRx.

*Qualifying persons may obtain medications directly from patient assistance programs without any out-of-pocket cost (or for less than $49 per medication). However, our monthly flat rate of just $49 per medication spares you the hassle of tracking the different programs and filling out all the required paperwork for each program. Subject to medication availability and acceptance by the pharmaceutical companies. NiceRx is not responsible for any delays or rejection by the pharmaceutical companies.

Enrollees enjoy a full-service solution, as NiceRx assists them and their physicians with the entire process. We prepare all required documents for the physician to sign, help enrollees manage all prescription refills, monitor eligibility criteria, and maintain enrollment.

**If you do not receive medications because you were determined to be ineligible for the prescription assistance by the applicable pharmaceutical companies and you have a letter of denial, we will refund any fees you paid toward medications for which you did not qualify to receive prescription assistance (“Refund”).

To receive a refund, you must send the letter of denial to us by fax to 888-517-7444, or by e-mail to [email protected] within 30 days of your receipt of such letter. The Refund is your sole and exclusive remedy for any fees you may wish to dispute.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.

DISCLAIMER: NiceRx is a conduit between consumers in need of prescription drug savings. NiceRx is not affiliated or contracted with any of the pharmaceutical companies or products which are illustrated on this website. NiceRx is not compensated in any capacity by any of the manufacturers. All of the information about prescription drugs on this website has not been provided to NiceRx by the manufacturer.