Santyl Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Santyl cost savings if eligible

The Santyl patient assistance program can provide your medication for free. We simply charge $49 per month for each medication to cover the cost of our services. With NiceRx, you will only pay $49 to obtain your Santyl, regardless of the retail price.

Am I eligible for the Santyl patient assistance program?

To find out if you are eligible for Santyl assistance you can apply online using our enrollment application. Each pharmaceutical company sets its eligibility criteria, and we will review your application individually to determine if you may be eligible. The three main factors to consider are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Santyl patient assistance program?

Our application process aims to make it as easy as possible to apply for the Santyl patient assistance program. The first step is to complete our online enrollment application. We will ask you for details about your healthcare provider, your insurance plan, and your household income as this information is required by the pharmaceutical companies. We may be able to help you apply for other patient assistance programs too, so be sure to tell us about any medications you are taking as well as Santyl.

NiceRx will review your application and determine whether you may be eligible for Santyl assistance. If so, we will handle the full enrollment process for you and prepare all required documents for your healthcare provider to sign. Once you are successfully enrolled in the Santyl patient assistance program, we will help you manage your prescription refills by requesting refills on your behalf throughout your enrollment period. At the end of your enrollment period, we will contact you for updated information and seek to re-enroll you so you can continue to access affordable Santyl.

Is NiceRx a Santyl coupons provider?

NiceRx is a service provider that helps eligible individuals access the Santyl patient assistance program. We do not offer trial offers or free Santyl samples. When obtaining your medication through NiceRx, you will only pay $49 a month per medication. This will likely save you more money than if you were to use Santyl coupons, discount cards, or Santyl copay cards.

Can NiceRx help me get Santyl if I have insurance?

NiceRx may be able to help you if your insurance company will not pay for your Santyl medication. We may also be able to help if you have a high copay or coinsurance responsibility. Whether you have insurance or not, apply online using our enrollment application to find out more.

How much does Santyl cost without insurance?

Santyl prices without insurance will vary depending on how much you buy. Prices will also vary by retailer. As a guide, Santyl (250 units/g) typically costs $300 for 30 grams.

How much does Santyl cost with insurance?

The copay for Santyl will vary by the terms of your healthcare plan. To find out what you might need to pay for Santyl with insurance, your insurance provider or pharmacist will be able to help you calculate the copay costs with your current insurance.

What is Santyl?

Collagenase Santyl Ointment (Santyl) is an FDA-approved biologic enzymatic debrider manufactured by Smith & Nephew, Inc. for the treatment of skin ulcers and severe burns in adults.

Santyl is a sterile enzymatic debriding ointment that contains 250 collagenase units per gram of white petrolatum USP. The enzyme collagenase is derived from the fermentation by Clostridium histolyticum. Collagenase is an enzyme that breaks down collagen in necrotic tissue helping healthy tissue to grow. Proper wound care management is important to help remove non-living tissue from your wounds and to help wounds heal faster.

What doses of Santyl are available?

Santyl is available in a topical ointment form, in the following doses: 250 units/gram.

Wash your hands before and after applying Santyl. You may need to clean the wound and reapply the ointment if the treated area becomes soiled. The enzymes in Santyl may increase your risk of infection in the bloodstream. If an infection is present, use an appropriate topical antibiotic powder. The antibiotic should be applied to the wound before the application of Santyl.

The best pH range of collagenase is 6 to 8. Higher or lower pH conditions will decrease the enzyme’s activity. The enzymatic activity is also adversely affected by certain detergents and heavy metal ions such as mercury and silver which are used in some antiseptics. When such materials have been used, the site should be carefully cleaned by repeated washings with normal saline before Santyl is used.

You are advised to speak with a healthcare professional for medical advice or about any changes to your dose so they can monitor and evaluate your condition.

Santyl active ingredients

Santyl contains collagenase as the active ingredient.

Santyl side effects

The most common side effects of Santyl in clinical trials include:

  •  Slight erythema

Your doctor will assess the benefits of using Santyl against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Santyl to the FDA. Visit, or call 1-800-FDA-1088.

Santyl drug interactions

There is currently no data available for Santyl interactions with other medications. Tell your healthcare provider about all the medicines you take, including prescription drugs and over-the-counter medicines, vitamins, and herbal supplements.

Santyl contraindications

You should not use Santyl if you:

  • Have local or systemic hypersensitivity to collagenase
  • Have had an allergic reaction to any of the other ingredients in Santyl

Talk to your doctor before using Santyl if you:

  • Are taking any of the medications that could interact with Santyl
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed

Santyl generic

Santyl is the trademark brand name for collagenase manufactured by Smith & Nephew, Inc. A generic version of collagenase is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Santyl savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.