medicationsSignifor Lar

Signifor LAR Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Signifor LAR cost savings if eligible

The Signifor LAR patient assistance program can provide your medication for free. We simply charge $49 per month for each medication to cover the cost of our services. With NiceRx, you will only pay $49 to obtain your Signifor LAR, regardless of the retail price.

Am I eligible for the Signifor LAR patient assistance program?

To find out if you are eligible for Signifor LAR assistance you can apply online using our enrollment application. Each pharmaceutical company sets its eligibility criteria, and we will review your application individually to determine if you may be eligible. The three main factors to consider are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Signifor LAR patient assistance program?

Our application process aims to make it as easy as possible to apply for the Signifor LAR patient assistance program. The first step is to complete our online enrollment application. We will ask you for details about your healthcare provider, your insurance plan, and your household income as this information is required by the pharmaceutical companies. We may be able to help you apply for other patient assistance programs too, so be sure to tell us about any medications you are taking as well as Signifor LAR.

NiceRx will review your application and determine whether you may be eligible for Signifor LAR assistance. If so, we will handle the full enrollment process for you and prepare all required documents for your healthcare provider to sign. Once you are successfully enrolled in the Signifor LAR patient assistance program, we will help you manage your prescription refills by requesting refills on your behalf throughout your enrollment period. At the end of your enrollment period we will contact you for updated information and seek to re-enroll you so you can continue to access affordable Signifor LAR.

Is NiceRx a Signifor LAR coupon provider?

NiceRx is a service provider that helps eligible individuals access the Signifor LAR patient assistance program. We do not offer trial offers or free Signifor LAR samples. When obtaining your medication through NiceRx, you will only pay $49 a month per medication. This will likely save you more money than if you were to use Signifor LAR coupons, discount cards, or Signifor LAR copay cards.

Can NiceRx help me get Signifor LAR cheaper if I have insurance?

NiceRx may be able to help you if your insurance company will not pay for your Signifor LAR medication. We may also be able to help if you have a high copay or coinsurance responsibility. Whether you have insurance or not, apply online using our enrollment application to find out more.

How much does Signifor LAR cost without insurance?

Signifor LAR prices without insurance will vary depending on how much you buy. Prices will also vary by retailer. As a guide, Signifor LAR intramuscular powder for injection, extended-release 10 mg typically costs $15,400 for 1 powder for injection.

How much does Signifor LAR cost with insurance?

The copay for Signifor LAR will vary by the terms of your healthcare plan. To find out what you might need to pay for Signifor LAR with insurance, your insurance provider or pharmacist will be able to help you calculate the copay costs with your current insurance.

What is Signifor LAR?

Signifor LAR is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Recordati. Signifor LAR is a somatostatin analog that decreases the amount of growth hormone made in the body. It is used to treat:

  • Patients with acromegaly who have not responded to surgery and/or for whom surgery is not an option. Treating acromegaly reduces the risk of serious problems such as diabetes and heart disease
  • Patients with Cushing’s disease for whom pituitary surgery is not an option or has not been curative. Cushing’s disease occurs when the body makes too much cortisol. High cortisol levels in the body may lead to high blood pressure and high blood sugar. Pasireotide works by decreasing the amount of cortisol made in the body

What doses of Signifor LAR are available?

Signifor LAR is available as an injectable suspension, in the following doses: 10 mg, 20 mg, 30 mg, 40 mg, and 60 mg, powder in a vial for reconstitution with 2 mL diluent.

Check fasting plasma glucose, hemoglobin A1c, liver enzyme tests, electrocardiogram (ECG), serum magnesium, and serum potassium, and ensure glucose levels are well controlled in patients with poorly controlled diabetes mellitus before starting treatment.

The initial dosage for acromegaly is 40 mg once every 4 weeks (every 28 days). The initial dosage for Cushing’s Disease is 10 mg by intramuscular injection once every 4 weeks (every 28 days).

For patients with hepatic impairment, Child-Pugh B the initial recommended dose for acromegaly is 20 mg once every 4 weeks with a maximum dose of 40 mg once every 4 weeks. For patients with hepatic impairment, Child-Pugh B the initial recommended dose for Cushing’s Disease is 10 mg once every 4 weeks with a maximum dose of 20 mg once every 4 weeks. Signifor LAR is not recommended for patients with Child-Pugh C.

If you miss a dose of Signifor LAR, you can receive your missed dose up to 14 days before your next dose. Signifor LAR can increase blood sugar levels and may cause diabetes. Your blood sugar may need to be tested before and during treatment.

Please read the full prescribing information for the instructions for use. If you have increased thirst or urination, tiredness, and weight loss speak with a healthcare professional so they can monitor and evaluate your condition.

Signifor LAR active ingredients

Signifor LAR contains pasireotide as the active ingredient.

Signifor LAR side effects

The most common side effects of Signifor LAR in clinical trials include:

  • Cholelithiasis (gallstones) – complications include inflammation and infection of the gall bladder
  • Hyperglycemia and diabetes mellitus, ketoacidosis
  • Injection site reactions
  • High blood pressure
  • Tiredness
  • Swelling, rapid weight gain
  • Headache, back pain
  • Cold symptoms
  • Hair loss
  • Unusual tiredness, weight loss

Signifor LAR can cause more serious side effects. These can include:

  • Suppression of pituitary hormones other than GH/IGF-1
  • Liver test elevations – check liver enzymes before starting treatment
  • Liver disease (such as loss of appetite, abdominal pain, bloating, yellowing of eyes/skin, dark urine
  • Bradycardia (slow heartbeat) and QT prolongation – check ECG and electrolytes before starting treatment
  • Pituitary hormone deficiency

Your doctor will assess the benefits of using Signifor LAR against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Signifor LAR to the FDA. Visit, or call 1-800-FDA-1088.

Signifor LAR drug interactions

Signifor LAR can interact with other medications. These include:

  • Drugs that prolong QT
  • Antiarrhythmics
  • Beta-blockers
  • Calcium channel blockers
  • Potassium and magnesium electrolytes
  • Cyclosporine
  • Bromocriptine – consider bromocriptine dose reduction

This list is not exhaustive and other prescription drugs may interact with Signifor LAR. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Signifor LAR contraindications

You should not use Signifor LAR if you:

  • Are allergic to the active ingredient pasireotide
  • Are allergic to any of the other ingredients in Signifor LAR
  • Are pregnant or are planning to become pregnant – there is potential for an unintended pregnancy

Talk to your doctor before using Signifor LAR if you:

  • Are taking any of the medications that could interact with Signifor LAR
  • Are breastfeeding or are planning to breastfeed

Signifor LAR generic

Signifor LAR is the trademark brand name for pasireotide manufactured by Recordati. A generic version of pasireotide is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Signifor LAR savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.