Siklos Coupon & Prices

Is your Siklos medication too expensive? Start receiving your medication for only $49 per month.*

Complete a free online enrollment application to find out if you’re eligible to pay only $49 per month for your Siklos medication with our help.

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  • NiceRx Benefit
    Secure: Your personal and medical information is safe with us
  • NiceRx Benefit
    Convenient: Your medication is delivered straight to your door
  • NiceRx Benefit
    Ongoing refills: Your medication is refilled automatically
  • NiceRx Benefit
    Secure: Your personal and medical information is safe with us
  • NiceRx Benefit
    Convenient: We manage the whole process and we’re here to assist you
  • NiceRx Benefit
    Ongoing refills: We request your medication refills on your behalf

NiceRx works with your healthcare provider to help you access affordable medications directly from U.S. pharmaceutical companies.

How it works

  • Enroll online

    Get started by filling out the online enrollment application to find out if you are eligible for assistance.

  • Pre-qualification

    NiceRx verifies your eligibility for medication assistance and notifies you if you are pre-qualified. The pharmaceutical company provides your medication for free, and you only pay our service fee.

  • Submit documents

    We will request documents to be submitted by you and your healthcare provider that are required by the pharmaceutical company to complete your enrollment.

  • Receive medication

    Once approved, the pharmaceutical company typically ships a 90-day supply of medication to your home or healthcare provider’s address. Final acceptance is determined by the pharmaceutical company.

Medically reviewed by  Jamie Winn, PharmD

Your monthly Siklos cost savings if eligible

If you are eligible to receive your Siklos prescription through the patient assistance program, your medication will be free. We charge a flat monthly service fee of $49 per medication to cover the cost of our services.

Am I eligible for Siklos patient assistance?

To be eligible for the Siklos patient assistance program, you will need to meet specific eligibility criteria set by the pharmaceutical company. At NiceRx, we review each Siklos enrollment application individually. The main factors considered are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Siklos patient assistance program?

Applying for the Siklos patient assistance program through NiceRx is simple. Begin by completing the enrollment application on our website. We will ask for details about your healthcare provider, your insurance plan, and your household income. This information is required by the pharmaceutical manufacturers that supply your medication. We may be able to help you access patient assistance for other medications as well as Siklos, so please tell us about any medications that you have been prescribed.

If we determine that you may be eligible for Siklos assistance, we will handle the full enrollment process on your behalf. We will work with your healthcare provider to prepare and submit all the documents required for you to enroll. If you are successfully enrolled in the Siklos patient assistance program, we will also request your Siklos medication refills on your behalf for up to 1 year. At the end of your enrollment period, we will contact you for updated details and seek to re-enroll you in the program.

Is NiceRx a Siklos coupon provider?

NiceRx does not provide Siklos coupons, discount cards or copay cards. We do not offer printable Siklos manufacturer coupons, Siklos discounts, rebates, Siklos savings cards, trial offers, or free samples. We are a service provider that helps eligible individuals access patient assistance programs. Our service cost is $49 a month per medication, so you will likely save more on your Siklos medication with NiceRx.

Can NiceRx help me get Siklos cheaper if I have insurance?

NiceRx may be able to help you access Siklos patient assistance if:

  • You have a high copay or coinsurance responsibility for Siklos
  • Your insurance company will not pay for your Siklos prescription
  • You do not have insurance

Complete your enrollment application online to find out more.

How much does Siklos cost without insurance?

Siklos prices without insurance will vary by retailer. As a guide, Siklos oral tablets 100 mg will typically cost around $360 for 60 tablets.

How much does Siklos cost with insurance?

Your individual healthcare plan will determine the copay of Siklos with insurance. To find out what you will need to pay, contact your pharmacist or insurance provider. They will be able to calculate your copay with your current insurance.

What is Siklos?

Siklos is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Addmedica. It is an antimetabolite, indicated to reduce the frequency of painful crises and to reduce the need for blood transfusions in pediatric patients, 2 years of age and older, with sickle cell anemia with recurrent moderate to severe painful crises.

Sickle cell disease (SCD) is a genetic disease that affects red blood cells. Individuals with the disease have abnormal red blood cells that are stiff and half-moon-shaped, causing them to become stuck in the blood vessels, blocking blood flow. Blockages can cause pain and organ damage, which require hospitalization.

What doses of Siklos are available?

Siklos is available in tablet form, in the following doses: 100 mg and functionally triple-scored 1,000 mg tablets.

Swallow Siklos tablets with a glass of water. If you are not able to swallow the tablets, you can dissolve your prescribed dose in a small amount of water in a teaspoon and swallow right away.

Your recommended dose is based on your body weight. The initial dose is 20 mg/kg once daily. Your dose may be increased by 5 mg/kg/day every 8 weeks, or sooner if a severe painful crisis occurs until a maximum tolerated dose, or 35 mg/kg/day is reached if blood counts are in an acceptable range. Reduce the dose by 50% in patients with renal impairment.

Read the medication guide and always speak with your healthcare provider for medical advice about any changes to your dose so they can monitor and evaluate your condition.

Siklos active ingredients

Siklos contains hydroxyurea as the active ingredient.

Siklos side effects

The most common side effects of Siklos in clinical trials include:

  • Loss of appetite, nausea
  • Constipation, diarrhea
  • Bleeding

In rare instances, Siklos can cause more serious adverse effects. These can include:

  • Severe myelosuppression – monitor blood counts at baseline and throughout treatment
  • Malignancies (leukemia and skin cancer)
  • Anemia – low red blood cells
  • Neutropenia – low white blood cells (can be severe and life-threatening)
  • Thrombocytopenia – reduced platelets
  • Numbness, tingling, or burning pain in your hands or feet
  • Skin ulcers
  • Sudden chest pain, wheezing, dry cough, feeling short of breath
  • Low blood cell counts – fever, chills, tiredness, mouth sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed
  • Liver or pancreas problems – loss of appetite, upper stomach pain, nausea or vomiting, increased heart rate, dark urine, yellowing of the skin or eyes
  • Embryo-fetal toxicity

Your doctor will assess the benefits of using Siklos against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Siklos to the FDA. Visit, or call 1-800-FDA-1088.

Siklos drug interactions

Siklos can interact with other medications. These include:

  • Antiretroviral drugs
  • Live vaccines

This list is not exhaustive and other prescription drugs may interact with Siklos. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Siklos contraindications

You should not use Siklos if you:

  • Are allergic to the active ingredient hydroxyurea
  • Are allergic to any of the other ingredients in Siklos
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed

Talk to your doctor before using Siklos if you:

  • Are taking any of the medications that could interact with Siklos

Siklos generic

Siklos is the trademark brand name for hydroxyurea manufactured by Addmedica and distributed by Medunik USA. A generic version of hydroxyurea is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Siklos savings through NiceRx.

*Qualifying persons may obtain medications directly from patient assistance programs without any out-of-pocket cost (or for less than $49 per medication). However, our monthly flat rate of just $49 per medication spares you the hassle of tracking the different programs and filling out all the required paperwork for each program. Subject to medication availability and acceptance by the pharmaceutical companies. NiceRx is not responsible for any delays or rejection by the pharmaceutical companies.

Enrollees enjoy a full-service solution, as NiceRx assists them and their physicians with the entire process. We prepare all required documents for the physician to sign, help enrollees manage all prescription refills, monitor eligibility criteria, and maintain enrollment.

**If you do not receive medications because you were determined to be ineligible for the prescription assistance by the applicable pharmaceutical companies and you have a letter of denial, we will refund any fees you paid toward medications for which you did not qualify to receive prescription assistance (“Refund”).

To receive a refund, you must send the letter of denial to us by fax to 888-517-7444, or by e-mail to [email protected] within 30 days of your receipt of such letter. The Refund is your sole and exclusive remedy for any fees you may wish to dispute.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.

DISCLAIMER: NiceRx is a conduit between consumers in need of prescription drug savings. NiceRx is not affiliated or contracted with any of the pharmaceutical companies or products which are illustrated on this website. NiceRx is not compensated in any capacity by any of the manufacturers. All of the information about prescription drugs on this website has not been provided to NiceRx by the manufacturer.