Sylvant Coupon & Prices

Is your Sylvant medication too expensive?

Get notified when Sylvant medication becomes available.

Get Started Now
Medically reviewed by  Jamie Winn, PharmD

Your monthly Sylvant cost savings if eligible

The Sylvant patient assistance program can provide your medication for free. We simply charge $49 per month for each medication to cover the cost of our services. With NiceRx, you will only pay $49 to obtain your Sylvant, regardless of the retail price.

Am I eligible for the Sylvant patient assistance program?

To find out if you are eligible for Sylvant assistance you can apply online using our enrollment application. Each pharmaceutical company sets its eligibility criteria, and we will review your application individually to determine if you may be eligible. The three main factors to consider are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Sylvant patient assistance program?

Our application process aims to make it as easy as possible to apply for the Sylvant patient assistance program. The first step is to complete our online enrollment application. We will ask you for details about your healthcare provider, your insurance plan, and your household income as this information is required by the pharmaceutical companies. We may be able to help you apply for other patient assistance programs too, so be sure to tell us about any medications you are taking as well as Sylvant.

NiceRx will review your application and determine whether you may be eligible for Sylvant assistance. If so, we will handle the full enrollment process for you and prepare all required documents for your healthcare provider to sign. Once you are successfully enrolled in the Sylvant patient assistance program, we will help you manage your prescription refills by requesting refills on your behalf throughout your enrollment period. At the end of your enrollment period we will contact you for updated information and seek to re-enroll you so you can continue to access affordable Sylvant.

Is NiceRx a Sylvant coupon provider?

NiceRx is a service provider that helps eligible individuals access the Sylvant patient assistance program. We do not offer trial offers or free Sylvant samples. When obtaining your medication through NiceRx, you will only pay $49 a month per medication. This will likely save you more money than if you were to use Sylvant coupons, discount cards, or Sylvant copay cards.

Can NiceRx help me get Sylvant cheaper if I have insurance?

NiceRx may be able to help you if your insurance company will not pay for your Sylvant medication. We may also be able to help if you have a high copay or coinsurance responsibility. Whether you have insurance or not, apply online using our enrollment application to find out more.

How much does Sylvant cost without insurance?

Sylvant prices without insurance will vary depending on how much you buy. Prices will also vary by retailer. As a guide, Sylvant intravenous powder for injection 100 mg typically costs $1,350 for 1 powder for injection.

How much does Sylvant cost with insurance?

The copay for Sylvant will vary by the terms of your healthcare plan. To find out what you might need to pay for Sylvant with insurance, your insurance provider or pharmacist will be able to help you calculate the copay costs with your current insurance.

What is Sylvant?

Sylvant is an FDA (U.S. Food and Drug Administration) approved medication manufactured by EUSA Pharma. It is an interleukin-6 (IL-6) antagonist indicated for the treatment of patients with multicentric Castleman’s disease (MCD) who are human immunodeficiency virus (HIV) negative and human herpesvirus-8 (HHV-8) negative.

MCD is a rare blood disorder with high morbidity in which lymphocytes are over-produced, leading to enlarged lymph nodes. MCD can also affect lymphoid tissue of internal organs, causing the liver, spleen, or other organs to enlarge. Infections, multisystem organ failure, and malignancies including malignant lymphoma are common causes of death in patients with MCD.

What doses of Sylvant are available?

Sylvant is available in lyophilized powder form, in the following doses: 100 mg of lyophilized powder in a single-use vial, 400 mg of lyophilized powder in a single-use vial.

Sylvant is for intravenous infusion only. The recommended dose is 11 mg/kg given over 1 hour by intravenous infusion every 3 weeks.

Please see the full prescribing information and always speak with a healthcare professional about any changes to your dose so they can monitor and evaluate your condition.

Sylvant active ingredients

The active substance in Sylvant, siltuximab, is a monoclonal antibody.

Sylvant side effects

The most common side effects of Sylvant in clinical trials compared to placebo include:

  • Pruritus
  • Weight gain
  • Rash
  • Hyperuricemia
  • Upper respiratory tract infection

In rare instances, Sylvant can cause more serious side effects. These can include:

  • Severe infusion-related reactions, anaphylaxis
  • Severe allergic reactions
  • Gastrointestinal (GI) perforation

Your caregiver will assess the benefits of using Sylvant against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Sylvant to the FDA. Visit, or call 1-800-FDA-1088.

Sylvant drug interactions

Sylvant can interact with other medications. These include:

  • Cytochrome P450s in the liver are downregulated by infection and inflammation stimuli including cytokines such as IL-6. Inhibition of IL-6 signaling in patients treated with Sylvant may restore CYP450 activities to higher levels leading to increased metabolism of drugs that are CYP450 substrates – oral contraceptives, lovastatin, atorvastatin
  • Vaccinations – do not administer live vaccines because IL-6 inhibition may interfere with the normal immune response to new antigens

This list is not exhaustive and other prescription drugs may interact with Sylvant.

Sylvant contraindications

You should not use Sylvant if you:

  • Have had a severe hypersensitivity reaction to the active ingredient siltuximab
  • Have had an allergic reaction to any of the other ingredients in Sylvant
  • Have a severe infection
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed

Talk to your doctor before using Sylvant if you:

  • Are taking any of the medications that could interact with Sylvant
  • Have a stomach or intestinal disorder, including ulcer or diverticulitis
  • Have gout

Sylvant generic

Sylvant is the trademark brand name for siltuximab manufactured by EUSA Pharma. A generic version of siltuximab is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Sylvant savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.