Sylvant Coupon & Prices

Is your Sylvant medication too expensive? Start receiving your medication for only $49 per month.*

Complete a free online enrollment application to find out if you’re eligible to pay only $49 per month for your Sylvant medication with our help.

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  • NiceRx Benefit
    Secure: Your personal and medical information is safe with us
  • NiceRx Benefit
    Convenient: Your medication is delivered straight to your door
  • NiceRx Benefit
    Ongoing refills: Your medication is refilled automatically
  • NiceRx Benefit
    Secure: Your personal and medical information is safe with us
  • NiceRx Benefit
    Convenient: We manage the whole process and we’re here to assist you
  • NiceRx Benefit
    Ongoing refills: We request your medication refills on your behalf

NiceRx works with your healthcare provider to help you access affordable medications directly from U.S. pharmaceutical companies.

How it works

  • Enroll online

    Get started by filling out the online enrollment application to find out if you are eligible for assistance.

  • Pre-qualification

    NiceRx verifies your eligibility for medication assistance and notifies you if you are pre-qualified. The pharmaceutical company provides your medication for free, and you only pay our service fee.

  • Submit documents

    We will request documents to be submitted by you and your healthcare provider that are required by the pharmaceutical company to complete your enrollment.

  • Receive medication

    Once approved, the pharmaceutical company typically ships a 90-day supply of medication to your home or healthcare provider’s address. Final acceptance is determined by the pharmaceutical company.

Medically reviewed by  Jamie Winn, PharmD

Your monthly Sylvant cost savings if eligible

The Sylvant patient assistance program can provide your medication for free. We simply charge $49 per month for each medication to cover the cost of our services. With NiceRx, you will only pay $49 to obtain your Sylvant, regardless of the retail price.

Am I eligible for the Sylvant patient assistance program?

To find out if you are eligible for Sylvant assistance you can apply online using our enrollment application. Each pharmaceutical company sets its eligibility criteria, and we will review your application individually to determine if you may be eligible. The three main factors to consider are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Sylvant patient assistance program?

Our application process aims to make it as easy as possible to apply for the Sylvant patient assistance program. The first step is to complete our online enrollment application. We will ask you for details about your healthcare provider, your insurance plan, and your household income as this information is required by the pharmaceutical companies. We may be able to help you apply for other patient assistance programs too, so be sure to tell us about any medications you are taking as well as Sylvant.

NiceRx will review your application and determine whether you may be eligible for Sylvant assistance. If so, we will handle the full enrollment process for you and prepare all required documents for your healthcare provider to sign. Once you are successfully enrolled in the Sylvant patient assistance program, we will help you manage your prescription refills by requesting refills on your behalf throughout your enrollment period. At the end of your enrollment period we will contact you for updated information and seek to re-enroll you so you can continue to access affordable Sylvant.

Is NiceRx a Sylvant coupon provider?

NiceRx is a service provider that helps eligible individuals access the Sylvant patient assistance program. We do not offer trial offers or free Sylvant samples. When obtaining your medication through NiceRx, you will only pay $49 a month per medication. This will likely save you more money than if you were to use Sylvant coupons, discount cards, or Sylvant copay cards.

Can NiceRx help me get Sylvant cheaper if I have insurance?

NiceRx may be able to help you if your insurance company will not pay for your Sylvant medication. We may also be able to help if you have a high copay or coinsurance responsibility. Whether you have insurance or not, apply online using our enrollment application to find out more.

How much does Sylvant cost without insurance?

Sylvant prices without insurance will vary depending on how much you buy. Prices will also vary by retailer. As a guide, Sylvant intravenous powder for injection 100 mg typically costs $1,350 for 1 powder for injection.

How much does Sylvant cost with insurance?

The copay for Sylvant will vary by the terms of your healthcare plan. To find out what you might need to pay for Sylvant with insurance, your insurance provider or pharmacist will be able to help you calculate the copay costs with your current insurance.

What is Sylvant?

Sylvant is an FDA (U.S. Food and Drug Administration) approved medication manufactured by EUSA Pharma. It is an interleukin-6 (IL-6) antagonist indicated for the treatment of patients with multicentric Castleman’s disease (MCD) who are human immunodeficiency virus (HIV) negative and human herpesvirus-8 (HHV-8) negative.

MCD is a rare blood disorder with high morbidity in which lymphocytes are over-produced, leading to enlarged lymph nodes. MCD can also affect lymphoid tissue of internal organs, causing the liver, spleen, or other organs to enlarge. Infections, multisystem organ failure, and malignancies including malignant lymphoma are common causes of death in patients with MCD.

What doses of Sylvant are available?

Sylvant is available in lyophilized powder form, in the following doses: 100 mg of lyophilized powder in a single-use vial, 400 mg of lyophilized powder in a single-use vial.

Sylvant is for intravenous infusion only. The recommended dose is 11 mg/kg given over 1 hour by intravenous infusion every 3 weeks.

Please see the full prescribing information and always speak with a healthcare professional about any changes to your dose so they can monitor and evaluate your condition.

Sylvant active ingredients

The active substance in Sylvant, siltuximab, is a monoclonal antibody.

Sylvant side effects

The most common side effects of Sylvant in clinical trials compared to placebo include:

  • Pruritus
  • Weight gain
  • Rash
  • Hyperuricemia
  • Upper respiratory tract infection

In rare instances, Sylvant can cause more serious side effects. These can include:

  • Severe infusion-related reactions, anaphylaxis
  • Severe allergic reactions
  • Gastrointestinal (GI) perforation

Your caregiver will assess the benefits of using Sylvant against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Sylvant to the FDA. Visit, or call 1-800-FDA-1088.

Sylvant drug interactions

Sylvant can interact with other medications. These include:

  • Cytochrome P450s in the liver are downregulated by infection and inflammation stimuli including cytokines such as IL-6. Inhibition of IL-6 signaling in patients treated with Sylvant may restore CYP450 activities to higher levels leading to increased metabolism of drugs that are CYP450 substrates – oral contraceptives, lovastatin, atorvastatin
  • Vaccinations – do not administer live vaccines because IL-6 inhibition may interfere with the normal immune response to new antigens

This list is not exhaustive and other prescription drugs may interact with Sylvant.

Sylvant contraindications

You should not use Sylvant if you:

  • Have had a severe hypersensitivity reaction to the active ingredient siltuximab
  • Have had an allergic reaction to any of the other ingredients in Sylvant
  • Have a severe infection
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed

Talk to your doctor before using Sylvant if you:

  • Are taking any of the medications that could interact with Sylvant
  • Have a stomach or intestinal disorder, including ulcer or diverticulitis
  • Have gout

Sylvant generic

Sylvant is the trademark brand name for siltuximab manufactured by EUSA Pharma. A generic version of siltuximab is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Sylvant savings through NiceRx.

*Qualifying persons may obtain medications directly from patient assistance programs without any out-of-pocket cost (or for less than $49 per medication). However, our monthly flat rate of just $49 per medication spares you the hassle of tracking the different programs and filling out all the required paperwork for each program. Subject to medication availability and acceptance by the pharmaceutical companies. NiceRx is not responsible for any delays or rejection by the pharmaceutical companies.

Enrollees enjoy a full-service solution, as NiceRx assists them and their physicians with the entire process. We prepare all required documents for the physician to sign, help enrollees manage all prescription refills, monitor eligibility criteria, and maintain enrollment.

**If you do not receive medications because you were determined to be ineligible for the prescription assistance by the applicable pharmaceutical companies and you have a letter of denial, we will refund any fees you paid toward medications for which you did not qualify to receive prescription assistance (“Refund”).

To receive a refund, you must send the letter of denial to us by fax to 888-517-7444, or by e-mail to [email protected] within 30 days of your receipt of such letter. The Refund is your sole and exclusive remedy for any fees you may wish to dispute.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.

DISCLAIMER: NiceRx is a conduit between consumers in need of prescription drug savings. NiceRx is not affiliated or contracted with any of the pharmaceutical companies or products which are illustrated on this website. NiceRx is not compensated in any capacity by any of the manufacturers. All of the information about prescription drugs on this website has not been provided to NiceRx by the manufacturer.