Symdeko Coupon & Prices

Is your Symdeko medication too expensive? Start receiving your medication for only $49 per month.*

Complete a free online enrollment application to find out if you’re eligible to pay only $49 per month for your Symdeko medication with our help.

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  • NiceRx Benefit
    Secure: Your personal and medical information is safe with us
  • NiceRx Benefit
    Convenient: We manage the whole process and we’re here to assist you
  • NiceRx Benefit
    Ongoing refills: We request your medication refills on your behalf
  • NiceRx Benefit
    Secure: Your personal and medical information is safe with us
  • NiceRx Benefit
    Convenient: We manage the whole process and we’re here to assist you
  • NiceRx Benefit
    Ongoing refills: We request your medication refills on your behalf

NiceRx works with your healthcare provider to help you access affordable medications directly from U.S. pharmaceutical companies.

How it works

  • Enroll online

    Get started by filling out the online enrollment application to find out if you are eligible for assistance.

  • Pre-qualification

    NiceRx verifies your eligibility for medication assistance and notifies you if you are pre-qualified. The pharmaceutical company provides your medication for free, and you only pay our service fee.

  • Submit documents

    We will request documents to be submitted by you and your healthcare provider that are required by the pharmaceutical company to complete your enrollment.

  • Receive medication

    Once approved, the pharmaceutical company typically ships a 90-day supply of medication to your home or healthcare provider’s address. Final acceptance is determined by the pharmaceutical company.

Medically reviewed by  Jamie Winn, PharmD

Your monthly Symdeko cost savings if eligible

The Symdeko patient assistance program can provide your medication for free. We simply charge $49 per month for each medication to cover the cost of our services. With NiceRx, you will only pay $49 to obtain your Symdeko, regardless of the retail price.

Am I eligible for the Symdeko patient assistance program?

To find out if you are eligible for Symdeko assistance you can apply online using our enrollment application. Each pharmaceutical company sets its eligibility criteria, and we will review your application individually to determine if you may be eligible. The three main factors to consider are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Symdeko patient assistance program?

Our application process aims to make it as easy as possible to apply for the Symdeko patient assistance program. The first step is to complete our online enrollment application. We will ask you for details about your healthcare provider, your insurance plan, and your household income as this information is required by the pharmaceutical companies. We may be able to help you apply for other patient assistance programs too, so be sure to tell us about any medications you are taking as well as Symdeko.

NiceRx will review your application and determine whether you may be eligible for Symdeko assistance. If so, we will handle the full enrollment process for you and prepare all required documents for your healthcare provider to sign. Once you are successfully enrolled in the Symdeko patient assistance program, we will help you manage your prescription refills by requesting refills on your behalf throughout your enrollment period. At the end of your enrollment period, we will contact you for updated information and seek to re-enroll you so you can continue to access affordable Symdeko.

Is NiceRx a Symdeko coupons provider?

NiceRx is a service provider that helps eligible individuals access the Symdeko patient assistance program. We do not offer trial offers or free Symdeko samples. When obtaining your medication through NiceRx, you will only pay $49 a month per medication. This will likely save you more money than if you were to use Symdeko coupons, discount cards, or Symdeko copay cards.

Can NiceRx help me get Symdeko if I have insurance?

NiceRx may be able to help you if your insurance company will not pay for your Symdeko medication. We may also be able to help if you have a high copay or coinsurance responsibility. Whether you have insurance or not, apply online using our enrollment application to find out more.

How much does Symdeko cost without insurance?

Symdeko prices without insurance will vary depending on how much you buy. Prices will also vary by retailer. As a guide, Symdeko oral tablet (75 mg-50 mg and ivacaftor 75 mg) typically costs $25,500 for 56 tablets.

How much does Symdeko cost with insurance?

The copay for Symdeko will vary by the terms of your healthcare plan. To find out what you might need to pay for Symdeko with insurance, your insurance provider or pharmacist will be able to help you calculate the copay costs with your current insurance.

What is Symdeko?

Symdeko is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Vertex Pharmaceuticals Incorporated. Symdeko is a combination of tezacaftor and ivacaftor, indicated for the treatment of patients with cystic fibrosis, CF aged 12 years and older who are homozygous for the F508del mutation or who have at least one mutation in the cystic fibrosis transmembrane conductance regulator (CFTR gene) that is responsive to tezacaftor/ivacaftor based on in vitro data and/or clinical evidence. Symdeko is now approved for patients 6 years of age and older with two copies of the F508del mutation.

If the patient’s genotype is unknown, an FDA-cleared CF mutation test should be used to detect the presence of a CFTR mutation followed by verification with bi-directional sequencing when recommended by the mutation test instructions for use.

A healthy CFTR protein helps cells move chloride, an element in salt, to the cell surface. In CF, the body creates a “broken” CFTR protein that cannot move chloride properly. Without chloride, water isn’t attracted to the cell surface, resulting in a thick, sticky mucus building up in the lungs and other organs.

What doses of Symdeko are available?

Symdeko is available in tablet form, in the following doses: tezacaftor 100 mg/ivacaftor 150 mg fixed-dose combination tablets and ivacaftor 150 mg tablets

The recommended dose in adults and pediatric patients ages 12 years and older is one tablet (containing tezacaftor 100 mg/ivacaftor 150 mg) in the morning and one tablet (containing ivacaftor 150 mg) in the evening, approximately 12 hours apart. Symdeko should be taken with fat-containing food. Reduce the dose in patients with moderate and severe hepatic impairment, and when co-administered with drugs that are moderate or strong CYP3A inhibitors.

If you miss a dose, take the medicine as soon as you can, but skip the missed dose if you are more than 6 hours late. Do not take two doses at one time. Be sure to take a missed dose with a food that contains fat. Please read the prescribing information, and always speak with your healthcare provider for medical advice or about any changes to your dose so they can monitor and evaluate your condition.

Symdeko active ingredients

Syndeko contains tezacaftor, a cystic fibrosis transmembrane conductance regulator (CFTR) corrector, and ivacaftor a CFTR potentiator.

Symdeko side effects

The most common side effects of Symdeko in clinical trials compared to placebo include:

  • Headache
  • Nausea
  • Sinus congestion
  • Dizziness

In rare instances, Symdeko can cause more serious side effects. These can include:

  • Vision problems
  • Liver problems – loss of appetite, stomach pain (upper right side), dark urine, yellowing of the skin or eyes
  • Elevated transaminases (ALT or AST)
  • Cataracts – baseline and follow-up examinations are recommended in pediatric patients initiating treatment

Your doctor will assess the benefits of using Symdeko against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Symdeko to the FDA. Visit, or call 1-800-FDA-1088.

Symdeko drug interactions

Symdeko can interact with other medications. These include:

  • CYP3A inhibitors – ketoconazole, fluconazole, voriconazole
  • CYP3A inducers – rifampin, rifabutin, St. John’s wort
  • Seizure medicine – carbamazepine, phenobarbital, phenytoin
  • Antibiotics such as telithromycin, clarithromycin, or erythromycin
  • Avoid food containing grapefruit or Seville oranges

This list is not exhaustive and other prescription drugs may interact with Symdeko. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Symdeko contraindications

You should not use Symdeko if you:

  • Are allergic to the active ingredients tezacaftor or ivacaftor
  • Are allergic to any of the other ingredients in Symdeko

Talk to your doctor about your medical condition before using Symdeko if you:

  • Are taking any of the medications that could interact with Symdeko
  • Have liver disease
  • Have kidney disease
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed

Symdeko generic

Symdeko is the trademark brand name for tezacaftor/ivacaftor and ivacaftor manufactured by Vertex Pharmaceuticals Incorporated. A generic version of tezacaftor/ivacaftor and ivacaftor is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Symdeko savings through NiceRx.

Related conditions

*Qualifying persons may obtain medications directly from patient assistance programs without any out-of-pocket cost (or for less than $49 per medication). However, our monthly flat rate of just $49 per medication spares you the hassle of tracking the different programs and filling out all the required paperwork for each program. Subject to medication availability and acceptance by the pharmaceutical companies. NiceRx is not responsible for any delays or rejection by the pharmaceutical companies.

Enrollees enjoy a full-service solution, as NiceRx assists them and their physicians with the entire process. We prepare all required documents for the physician to sign, help enrollees manage all prescription refills, monitor eligibility criteria, and maintain enrollment.

**If you do not receive medications because you were determined to be ineligible for the prescription assistance by the applicable pharmaceutical companies and you have a letter of denial, we will refund any fees you paid toward medications for which you did not qualify to receive prescription assistance (“Refund”).

To receive a refund, you must send the letter of denial to us by fax to 888-517-7444, or by e-mail to [email protected] within 30 days of your receipt of such letter. The Refund is your sole and exclusive remedy for any fees you may wish to dispute.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.