Symproic Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Is NiceRx a Symproic coupon provider?

NiceRx does not provide Symproic coupons, discount cards, or copay cards. We do not offer printable Symproic manufacturer coupons, Symproic discounts, rebates, Symproic savings cards, trial offers, or free samples. We are a service provider that helps eligible individuals access patient assistance programs. Our service cost is $49 a month per medication, so you will likely save more on your Symproic medication with NiceRx.

Symproic patient assistance program

Patient assistance programs are typically sponsored by pharmaceutical companies and provide free or discounted medications to individuals with low income who are uninsured or under-insured and meet the eligibility criteria that vary by program. There are currently no known patient assistance programs for this medication.

Can NiceRx help me get Symproic cheaper if I have insurance?

How much does Symproic cost without insurance?

Symproic prices without insurance will vary by retailer. As a guide, Symproic 0.2 mg tablets will typically cost around $550 for 30.

How much does Symproic cost with insurance?

Your individual healthcare plan will determine the copay of Symproic with insurance. To find out what you will need to pay, contact your pharmacist or insurance provider. They will be able to calculate your copay with your current insurance.

What is Symproic?

Symproic is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Shionogi Inc. It is an opioid antagonist for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain. Constipation is a common and unpleasant side effect of opioid treatment.

What doses of Symproic are available?

Symproic is available in tablet form, in the following doses: 0.2 mg.

In adults, the recommended dosage is 0.2 mg once daily with or without food. Discontinue treatment if the opioid pain medication is discontinued.

Please read the full prescribing information, medication labeling, and the medication guide, and always speak with your healthcare provider about any changes to your dose so they can monitor and evaluate your condition.

Symproic active ingredients

Symproic contains naldemedine as the active ingredient. It is classed as a peripheral opioid receptor antagonist. It is not a laxative.

Symproic side effects

The most common side effects of Symproic in clinical trials compared to placebo include:

  • Abdominal pain
  • Stomach pain
  • Diarrhea
  • Nausea, and vomiting (gastroenteritis)

In rare instances, Symproic can cause more serious adverse effects. These can include:

  • Gastrointestinal perforation
  • Symptoms of opioid withdrawal

Your doctor will assess the benefits of using Symproic against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Symproic to the FDA. Visit, or call 1-800-FDA-1088.

Symproic drug interactions

Symproic can interact with other medications. These include:

  • Strong CYP3A inducers – rifampin
  • Other opioid antagonists
  • Moderate and strong CYP3A4 inhibitors – fluconazole, itraconazole
  • P-gp inhibitors – amiodarone, captopril, cyclosporine, quercetin, quinidine, verapamil
  • St. John’s wort
  • Drugs used to treat seizures – carbamazepine, phenobarbital, phenytoin

This list is not exhaustive and other prescription drugs may interact with Symproic. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Symproic contraindications

You should not use Symproic if you:

  • Are allergic to the active ingredient naldemedine
  • Are allergic to any of the other ingredients in Symproic
  • Have a known or suspected gastrointestinal blockage
  • Are breastfeeding or are planning to breastfeed

Talk to your doctor before using Symproic if you:

  • Are taking any of the medications that could interact with Symproic
  • Have hepatic Impairment
  • Have a stomach or intestinal disorder (including Crohn’s disease, diverticulitis, or Ogilvie’s syndrome)
  • Have a stomach ulcer
  • Have known or suspected lesions of the GI tract
  • Are pregnant or are planning to become pregnant – May cause opioid withdrawal in a fetus

Symproic generic

Symproic is the trademark brand name for naldemedine manufactured by Shionogi Inc. A generic version of naldemedine is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Symproic savings through NiceRx.

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The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.