Synarel Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Synarel cost savings if eligible

With our assistance, you could access the Synarel patient assistance program and obtain your medication for free. We only charge a flat monthly fee of $49 per medication for our services.

Am I eligible for Synarel patient assistance?

We review each Synarel enrollment application individually to determine if you are eligible. Each assistance program has its own eligibility criteria and the factors considered by most programs are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Synarel patient assistance program?

Our process makes it as easy as possible to apply for the Synarel patient assistance program. Begin by completing the enrollment application form on our website. Tell us about any medications that you are taking, including Synarel, your healthcare provider, your insurance plan, and your household income. This information is required by the pharmaceutical manufacturers who will supply the medication, so it is important to make sure this information is accurate and up to date.

We will review the information that you have provided to determine whether you are eligible for patient assistance. If we can pre-qualify you for assistance, NiceRx will handle the full enrollment process on your behalf. If you are approved by the pharmaceutical company, you will typically start receiving your medication in 6 – 8 weeks.

Is NiceRx a Synarel coupon provider?

NiceRx is not a Synarel coupon, Synarel discount card, or Synarel copay card provider. We do not offer Synarel manufacturer coupons, Synarel discounts, rebates, Synarel savings cards, trial offers, or free Synarel samples. We are a service provider that helps eligible individuals access their medication directly from the U.S. pharmaceutical company.

Can NiceRx help me get Synarel cheaper if I have insurance?

NiceRx may be able to help you if:

  • You have a high copay or coinsurance responsibility for Synarel
  • Your insurance company will not pay for your Synarel prescription
  • Your healthcare plan does not cover your medication
  • You do not have insurance

Please apply online to find out if we can help you.

How much does Synarel cost without insurance?

Without insurance, Synarel costs will vary depending on where you buy the medication as prices will vary by retailer. As a guide, Synarel nasal spray (0.2 mg/inh) will cost around $3,100 for 8 milliliters.

How much does Synarel cost with insurance?

The copay for Synarel will depend on the terms of your healthcare plan. Your healthcare provider or pharmacist will be able to calculate your copay with your current insurance. Contact them to find out more.

What is Synarel?

Synarel is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Pfizer Limited. Synarel is used to treat central precocious puberty in boys and girls. Central precocious puberty is early sexual development that occurs at or before 8 years of age in girls or 9 years of age in boys, with advanced bone development for the child’s age.

Nafarelin is a potent gonadotropin-releasing hormone, GnRH agonist analogue. It works by decreasing the testosterone hormones in boys and estrogen hormones in women and girls. Synarel is also used to treat endometriosis in women who are at least 18 years old.

What doses of Synarel are available?

Synarel is available as a nasal spray, in the following doses: 2 mg in 1mL.

The recommended daily dose of Synarel is 200 mcg twice daily as one spray (200 mcg of nafarelin) to one nostril in the morning and one spray into the other nostril in the evening (400 mcg/day). Start treatment between days 2 and 4 of the menstrual cycle. The recommended duration of therapy is six months; only one 6-month course is advised.

Avoid sneezing during or right after using this medication because this may decrease the amount of medication absorbed. If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time.

If you need to use a nasal decongestant spray while using this medication, wait at least 2 hours after using this prescription drug before using the decongestant.

Please read the full prescribing information and always speak with a healthcare professional for medical advice about any changes to your dose so they can monitor and evaluate your condition.

Synarel active ingredients

The active ingredient of Synarel is nafarelin acetate.

Synarel side effects

The most common side effects of Synarel in clinical trials include:

  • Vaginal bleeding, discharge, or vaginal dryness
  • Hot flashes
  • Acne
  • Increase or decrease in breast size
  • Runny nose
  • Headaches
  • Muscle pain
  • Mood changes
  • Decreased interest in sex
  • Increased body odor
  • Increase in pubic hair
  • Nasal irritation

In rare instances, Synarel can cause more serious side effects. These can include:

  • Vaginal spotting or continued menstrual bleeding
  • Pelvic pain or swelling
  • Seizures
  • Pituitary gland problems – sudden headache, confusion, vision changes, vomiting, weak pulse, slowed breathing
  • Lower back pain, bone pain, irregular heartbeat, numbness/tingling of arms/legs, eye pain
  • Changes in bone density

Your doctor will assess the benefits of using Synarel against your risk of adverse events. Patients are encouraged to report negative side effects or adverse reactions of Synarel to the FDA. Visit, or call 1-800-FDA-1088.

Synarel drug interactions

Synarel can interact with other medications. These include:

  • Antidepressants
  • Treatments for seizures
  • Steroid treatments

This list is not exhaustive and other prescription drugs may interact with Synarel. Tell your healthcare provider about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Synarel contraindications

You should not use Synarel if you:

  • Are allergic to the active ingredient nafarelin or similar medicines such as goserelin, leuprolide, histrelin, or triptorelin
  • Have had an allergic reaction to any of the other ingredients in Synarel
  • Have abnormal vaginal bleeding that has not been checked by a doctor
  • Are pregnant or are planning to become pregnant – When used at the recommended dose, nafarelin inhibits ovulation. Also, Synarel can make hormonal birth control less effective, including birth control pills, injections, implants, skin patches, and vaginal rings. Use a barrier form of birth control, such as a condom, diaphragm, cervical cap, or contraceptive sponge during treatment
  • Are breastfeeding or are planning to breastfeed

Talk to your doctor before using Synarel if you:

  • Are taking any of the medications that could interact with Synarel
  • Have epilepsy or other seizure disorders
  • Have a mental health illness
  • Have a tumor or blood vessel problem in your brain
  • Have polycystic ovary disease
  • Have a low bone mineral density
  • Have a family history of osteoporosis
  • Smoke or drink large amounts of alcohol

Synarel generic

Synarel is the trademark brand name for nafarelin acetate manufactured by Pfizer Limited. A generic version of nafarelin acetate is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Synarel savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.