medicationsSynjardy Xr

Synjardy XR Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Synjardy XR cost savings if you are eligible

If you are eligible to receive your Synjardy XR prescription through the patient assistance program, your medication will be free. We charge a flat monthly service fee of $49 per medication to cover the cost of our services.

Am I eligible for Synjardy XR patient assistance?

To be eligible for the Synjardy XR patient assistance program, you will need to meet specific eligibility criteria set by the pharmaceutical company. At NiceRx, we review each Synjardy XR enrollment application individually. The main factors considered are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Synjardy XR patient assistance program?

Applying for the Synjardy XR patient assistance program through NiceRx is simple. Begin by completing the enrollment application on our website. We will ask for details about your healthcare provider, your insurance plan, and your household income. This information is required by the pharmaceutical manufacturers that supply your medication. We may be able to help you access patient assistance for other medications as well as Synjardy XR, so please tell us about any medications that you have been prescribed.

If we determine that you may be eligible for Synjardy XR assistance, we will handle the full enrollment process on your behalf. We will work with your healthcare provider to prepare and submit all the documents required for you to enroll. If you are successfully enrolled in the Synjardy XR patient assistance program, we will also request your Synjardy XR medication refills on your behalf for up to 1 year. At the end of your enrollment period, we will contact you for updated details and seek to re-enroll you in the program.

Is NiceRx a Synjardy XR coupons provider?

NiceRx does not provide Synjardy XR coupons, discount cards or copay cards. We do not offer printable Synjardy XR manufacturer coupons, Synjardy XR discounts, rebates, Synjardy XR savings cards, trial offers, or free samples. We are a service provider that helps eligible individuals access patient assistance programs. Our service cost is $49 a month per medication, so you will likely save more on your Synjardy XR medication with NiceRx.

Can NiceRx help me get Synjardy XR if I have insurance?

NiceRx may be able to help you access Synjardy XR patient assistance if:

  • You have a high copay or coinsurance responsibility for Synjardy XR
  • Your insurance company will not pay for your Synjardy XR prescription
  • You do not have insurance

Complete your enrollment application online to find out more.

How much does Synjardy XR cost without insurance?

Synjardy XR prices without insurance will vary by retailer. As a guide, Synjardy XR oral tablets, extended-release (10 mg-1000 mg) will typically cost around $600 for 30 tablets.

How much does Synjardy XR cost with insurance?

Your individual healthcare plan will determine the copay of Synjardy XR with insurance. To find out what you will need to pay, contact your pharmacist or insurance provider. They will be able to calculate your copay with your current insurance.

What is Synjardy XR?

Synjardy XR is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Boehringer Ingelheim Pharmaceuticals, Inc. It is a combination of empagliflozin, a sodium-glucose co-transporter 2 inhibitor, and metformin hydrochloride, a biguanide, indicated alongside diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Synjardy XR is also used to lower the risk of cardiovascular death from a heart attack, stroke, or heart failure in adults with type 2 diabetes who also have heart disease. Synjardy XR is not recommended in patients with type 1 diabetes mellitus as it may increase the risk of diabetic ketoacidosis in these patients.

Metformin-associated lactic acidosis has resulted in death, hypothermia, hypotension low blood pressure), and resistant bradyarrhythmias. Symptoms of lactic acidosis are unusual tiredness, dizziness, severe drowsiness, chills, blue cold skin, muscle pain, trouble breathing, slow irregular heartbeat, or stomach pain with nausea, vomiting, and diarrhea. Laboratory abnormalities include increased blood lactate levels, anion gap acidosis, increased lactate pyruvate ratio, and metformin plasma levels generally >5 mcg/mL.

Risk factors for lactic acidosis include concomitant use of certain drugs, if you are an older adult over 65 years of age, if you have kidney problems or liver problems, dehydration, heart failure, heavy alcohol use, or if you have had surgery.

What doses of Synjardy XR are available?

Synjardy XR is available in extended-release tablet form, in the following doses: 5 mg empagliflozin/1000 mg metformin HCl extended-release, 10 mg empagliflozin/1000 mg metformin HCl extended-release, 12.5 mg empagliflozin/1000 mg metformin HCl extended-release, 25 mg empagliflozin/1000 mg metformin HCl extended-release.

Assess renal function before starting treatment. The maximum recommended total daily dose is 25 mg empagliflozin and 2000 mg metformin HCl. Take once daily with a meal in the morning, with a gradual dose increase to reduce the gastrointestinal side effects due to metformin. Swallow the tablets whole, do not split, crush, dissolve, or chew.

Please read the full prescribing information for the boxed warning and medication guide and always speak with a healthcare professional for medical advice, or about any changes to your dose so they can monitor and evaluate your condition.

Synjardy XR active ingredients

Synjardy XR contains empagliflozin or metformin as the active ingredients.

Synjardy XR side effects

The most common side effects of Synjardy XR in clinical trials include:

  • Urinary tract infection
  • Female genital mycotic infections
  • Diarrhea
  • Nausea, vomiting
  • Flatulence, abdominal discomfort, indigestion
  • Weakness
  • Headache

In rare instances, Synjardy XR can cause more serious side effects. These can include:

  • Lactic acidosis – assess patients who show signs of metabolic acidosis for ketoacidosis, regardless of blood glucose level
  • Volume depletion – assess volume status and renal function in patients with impaired renal function, elderly patients, or patients on loop diuretics
  • Urosepsis and pyelonephritis
  • Risk of hypoglycemia (low blood sugar levels)
  • Necrotizing fasciitis of the perineum (Fournier’s Gangrene)
  • Hypersensitivity reactions
  • Vitamin B12 deficiency

Your doctor will assess the benefits of using Synjardy XR against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Synjardy XR to the FDA. Visit, or call 1-800-FDA-1088.

Synjardy XR drug interactions

Synjardy XR can interact with other medications. These include:

  • Carbonic anhydrase inhibitors may increase the risk of lactic acidosis
  • Drugs that reduce metformin clearance such as ranolazine, vandetanib, dolutegravir, and cimetidine
  • Alcohol can increase the effect of metformin on lactate metabolism

This list is not exhaustive and other prescription drugs may interact with Synjardy XR. Tell your healthcare provider about all the medicines you take, including prescription or over‐the‐counter medicines, vitamins, or herbal supplements.

Synjardy XR contraindications

You should not use Synjardy XR if you:

  • Are allergic to the active ingredient empagliflozin or metformin
  • Have had an allergic reaction to any of the other ingredients in Synjardy XR
  • Have severe renal impairment, end-stage renal disease, or on dialysis
  • Have metabolic acidosis, including diabetic ketoacidosis

Talk to your doctor before using Synjardy XR if you:

  • Are taking any of the medications that could interact with Synjardy XR
  • Are pregnant or are planning to become pregnant – potential risk to a fetus, especially during the second and third trimesters
  • Are breastfeeding or are planning to breastfeed
  • Are a geriatric patient
  • Have renal impairment
  • Have hepatic Impairment

Synjardy XR generic

Synjardy XR is the trademark brand name for empagliflozin and metformin manufactured by Boehringer Ingelheim Pharmaceuticals, Inc. A generic version of empagliflozin and metformin is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Synjardy XR savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.