Synribo Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Synribo cost savings if eligible

If you are eligible for the Synribo patient assistance program you can receive your medication for free. Our monthly service fee of $49 per medication covers the cost of our services in applying for the program and requesting your ongoing refills on your behalf. If you obtain your Synribo through NiceRx, you will only pay $49 a month regardless of the retail price of your medication.

Am I eligible for the Synribo patient assistance program?

You could receive your Synribo without paying the full retail price if you meet the eligibility criteria for assistance. The eligibility requirements are set by the pharmaceutical companies that are providing assistance programs. At NiceRx, we review each application individually, although the main factors considered by most programs are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for Synribo patient assistance?

We do everything that we can to take the hassle and stress out of applying for patient assistance programs. Simply start by filling in our enrollment application. We will ask for details about your healthcare provider, your insurance, and your household income. This information is required by the pharmaceutical companies you are applying to for assistance. We may also be able to help you access patient assistance for other medications that you have been prescribed, so be sure to tell us about any medications you are taking as well as Synribo.

NiceRx will review the information you have provided, and if we determine that you may be eligible for assistance, we will seek to enroll you in the Synribo patient assistance program. We will handle the enrollment process for you by working with your healthcare provider and preparing all the required paperwork for your doctor to sign. We will also request your Synribo medication refills on your behalf for up to 1 year once you are enrolled in the program.

Is NiceRx a Synribo coupon provider?

At NiceRx, we help eligible individuals access the Synribo patient assistance program. This means that we are not a Synribo coupon, a Synribo discount card, or a Synribo copay card provider. We do not offer any medication trial offers, or free Synribo samples.

Can NiceRx help me get Synribo cheaper if I have insurance?

We may be able to help you if you have insurance, including if your insurance company will not pay for your Synribo medication, or you have a high copay or coinsurance responsibility. We may even be able to assist if you do not have insurance. Please fill in our enrollment application to find out more.

How much does Synribo cost without insurance?

Synribo costs without insurance will vary depending on how much you buy and the retailer you buy it from. As a guide, Synribo subcutaneous powder for injection 3.5 mg will typically cost around $1,300 for 1 powder for injection. If you obtain your medication through NiceRx, you will pay a flat monthly rate of $49 per medication regardless of its retail price.

How much does Synribo cost with insurance?

The copay of Synribo will vary in line with the specific terms of your healthcare plan. For further details about what you may need to pay, your insurance provider or pharmacist will be able to calculate the copay costs with your current insurance.

What is Synribo?

Synribo is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Teva Pharmaceuticals USA, Inc. Synribo is indicated for the treatment of adult patients with chronic or accelerated phase CML (chronic myeloid leukemia) with resistance and/or intolerance to two or more tyrosine kinase inhibitors (TKI).

What doses of Synribo are available?

Synribo is available as a lyophilized powder in a single-use vial dosage form containing 3.5 mg of omacetaxine mepesuccinate.

Synribo is for subcutaneous use. The recommended starting dose is 1.25 mg/m2 administered subcutaneously twice daily at approximately 12-hour intervals for 14 consecutive days every 28 days, over a 28-day cycle. The maintenance dose is 1.25 mg/m2 twice daily for 7 consecutive days of a 28-day cycle. Cycles should be repeated every 28 days until a hematologic response is achieved.

You can store vials in the refrigerator for up to 6 days or at room temperature for up to 12 hours. If a prefilled syringe reaches room temperature, you must use it within 12 hours after it was mixed.

Please see the full prescribing information for the medication guide and always speak with a healthcare professional about any changes to your dose so they can monitor and evaluate your condition.

Synribo active ingredients

Synribo contains the active ingredient omacetaxine mepesuccinate, a cephalotaxine ester. It is a protein synthesis inhibitor.

Synribo side effects

The most common side effects of Synribo in clinical trials include:

  • Thrombocytopenia (reduced platelet count)
  • Anemia
  • Neutropenia (reduced white blood cells)
  • Lymphopenia
  • Diarrhea, nausea, fatigue
  • Asthenia
  • Injection site reaction
  • Pyrexia
  • Infection
  • Hair loss

In rare instances, Synribo can cause more serious side effects. These can include:

  • Myelosuppression – severe and fatal thrombocytopenia, neutropenia, and anemia
  • Fatal cerebral hemorrhage and severe, non-fatal gastrointestinal hemorrhage
  • Glucose intolerance and hyperglycemia (high blood sugar) including hyperosmolar non-ketotic hyperglycemia
  • Embryo-fetal toxicity
  • Bone marrow failure
  • Febrile neutropenia

Your caregiver will assess the benefits of using Synribo against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Synribo to the FDA. Visit, or call 1-800-FDA-1088.

Synribo drug interactions

Synribo can interact with other medications. These include:

  • Anticoagulants, aspirin, non-steroidal anti-inflammatory drugs (NSAIDs) – may increase the risk of bleeding

This list is not exhaustive and other prescription drugs may interact with Synribo.

Synribo contraindications

You should not use Synribo if you:

  • Are allergic to the active ingredient omacetaxine mepesuccinate
  • Are allergic to any of the other ingredients in Synribo
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed

Talk to your doctor before using Synribo if you:

  • Are taking any of the medications that could interact with Synribo
  • Have recently had any kind of immunization or vaccination
  • Have diabetes
  • Have bleeding problems

Synribo generic

Synribo is the trademark brand name for omacetaxine mepesuccinate manufactured by Teva Pharmaceuticals USA, Inc. A generic version of omacetaxine mepesuccinate is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Synribo savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.