medicationsSynvisc One

Synvisc One Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Synvisc One cost savings if eligible

If you are eligible for the Synvisc One patient assistance program you can receive your medication for free. Our monthly service fee of $49 per medication covers the cost of our services in applying for the program and requesting your ongoing refills on your behalf. If you obtain your Synvisc One through NiceRx, you will only pay $49 a month regardless of the retail price of your medication.

Am I eligible for the Synvisc One patient assistance program?

You could receive your Synvisc One without paying the full retail price if you meet the eligibility criteria for assistance. The eligibility requirements are set by the pharmaceutical companies that are providing assistance programs. At NiceRx, we review each application individually, although the main factors considered by most programs are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for Synvisc One patient assistance?

We do everything that we can to take the hassle and stress out of applying for patient assistance programs. Simply start by filling in our enrollment application. We will ask for details about your healthcare provider, your insurance, and your household income. This information is required by the pharmaceutical companies you are applying to for assistance. We may also be able to help you access patient assistance for other medications that you have been prescribed, so be sure to tell us about any medications you are taking as well as Synvisc One.

NiceRx will review the information you have provided, and if we determine that you may be eligible for assistance, we will seek to enroll you in the Synvisc One patient assistance program. We will handle the enrollment process for you by working with your healthcare provider and preparing all the required paperwork for your doctor to sign. We will also request your Synvisc One medication refills on your behalf for up to 1 year once you are enrolled in the program.

Is NiceRx a Synvisc One coupons provider?

At NiceRx, we help eligible individuals access the Synvisc One patient assistance program. This means that we are not a Synvisc One coupon, a Synvisc One discount card, or a Synvisc One copay card provider. We do not offer any medication trial offers, or free Synvisc One samples.

Can NiceRx help me get Synvisc One if I have insurance?

We may be able to help you if you have insurance, including if your insurance company will not pay for your Synvisc One medication, or you have a high copay or coinsurance responsibility. We may even be able to assist if you do not have insurance. Please fill in our enrollment application to find out more.

How much does Synvisc One cost without insurance?

Synvisc One costs without insurance will vary depending on how much you buy and the retailer you buy it from. As a guide, Synvisc-One intra-articular solution (48 mg/6 mL) will typically cost around $1,050 for 6 milliliters. If you obtain your medication through NiceRx, you will pay a flat monthly rate of $49 per medication regardless of its retail price.

How much does Synvisc One cost with insurance?

The copay of Synvisc One will vary in line with the specific terms of your healthcare plan. For further details about what you may need to pay, your insurance provider or pharmacist will be able to calculate the copay costs with your current insurance.

What is Synvisc One?

Synvisc One is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Sanofi Genzyme. It is an elastoviscous fluid produced from chicken combs and is similar to the synovial fluid that surrounds the joints in your body. This fluid acts as a lubricant and shock absorber for the joints.

Synvisc-One is classed as a viscosupplementation and is used to treat knee pain caused by osteoarthritis of the knee. It is usually given after other arthritis medications such as NSAIDs or other analgesics (acetaminophen) have been tried without successful treatment of symptoms.

Combining Synvisc-One injections with other treatment methods, such as physical therapy or medication, it’s possible to relieve your joint pain and make a full recovery.

What doses of Synvisc One are available?

Synvisc One is available in injection form, in the following doses: 16 mg/2 mL, 48 mg/6 mL.

For at least 48 hours after your injection, avoid jogging, strenuous activity, high-impact sports, or weight-bearing activities for longer than 1 hour at a time.

Please read the prescribing information for the full patient information details, and always speak with a healthcare professional about any changes to your dose so they can monitor and evaluate your condition.

Synvisc One active ingredients

Synvisc One contains hylan G-F 20 as the active ingredient.

Synvisc One side effects

The most common side effects of Synvisc One in clinical trials include:

  • Acute inflammation – joint pain, swelling, effusion, and sometimes joint warmth and/or stiffness at the injection site
  • Muscle pain, difficulty walking
  • Fever, chills, nausea
  • Feeling numb or tingly sensation
  • Headache, dizziness
  • Fatigue
  • Itching or skin irritation around the injected knee

In rare instances, Synvisc One can cause more serious adverse events. These can include:

  • Severe pain or swelling around the knee after the injection

Your doctor will assess the benefits of using Synvisc One against your risk of side effects. Patients are encouraged to report adverse effects or adverse reactions of Synvisc One to the FDA. Visit, or call 1-800-FDA-1088.

Synvisc One drug interactions

Synvisc One can interact with other medications. These include:

  • Other intra-articular injectables
  • Benzalkonium chloride topical
  • Cetylpyridinium topical

This list is not exhaustive and other prescription drugs may interact with Synvisc One. You should tell your healthcare provider about all the medications you take, including other prescription drugs and over-the-counter medications, vitamins, and dietary or herbal supplements.

Synvisc One contraindications

You should not use Synvisc One if you:

  • Are allergic to the active ingredient hylan G-F 20
  • Have had an allergic reaction such as swelling of the face, tongue or throat, respiratory difficulty, rash, itching or hives to Synvisc or any hyaluronan-based products
  • Have a knee joint infection, skin disease, or infection around the area where the injection will be given

Talk to your doctor before using Synvisc One if you:

  • Are taking any of the medications that could interact with Synvisc One
  • Have blood clots or circulation problems in your legs, or an allergy to birds, feathers, avian proteins, or egg products
  • Have swelling of the legs due to problems with venous stasis or lymphatic drainage
  • Are younger than 21 years old
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed

Synvisc One generic

Synvisc One is the trademark brand name for hylan G-F 20 manufactured by Sanofi Genzyme. A generic version of hylan G-F 20 is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Synvisc One savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.