Tolak Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Is NiceRx a Tolak coupon provider?

At NiceRx, we help eligible individuals access patient assistance program. This means that we are not a Tolak coupon, a Tolak discount card, or a Tolak copay card provider. We do not offer any medication trial offers, or free Tolak samples.

Tolak patient assistance program

Patient assistance programs are typically sponsored by pharmaceutical companies and provide free or discounted medications to individuals with low income who are uninsured or under-insured and meet the eligibility criteria that vary by program. There are currently no known patient assistance programs for this medication.

How much does Tolak cost without insurance?

Tolak costs without insurance will vary depending on how much you buy and the retailer you buy it from. As a guide, Tolak topical cream 4% will typically cost around $270 for 40 grams.

How much does Tolak cost with insurance?

The copay of Tolak will vary in line with the specific terms of your healthcare plan. For further details about what you may need to pay, your insurance provider or pharmacist will be able to calculate the copay costs with your current insurance.

What is Tolak?

Tolak is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Hill Dermaceuticals. Tolak cream is classed as an antineoplastic antimetabolite. It is used for the treatment of skin lesions called actinic keratosis on the face, ears, or scalp.

What doses of Tolak are available?

Tolak is available in cream form, in the following doses: 0.04g in 1g.

Fluorouracil topical cream is for topical use only on the affected area of the skin. It is not for ophthalmic, oral, or intravaginal use. Wash your hands before and immediately after applying Tolak. Apply the cream to cover the affected skin condition with a thin film. You may need to use Tolak for up to 6 weeks. Do not use Tolak on or around your eyelids or in your eyes, nose, or mouth, or other mucous membranes.

Topical fluorouracil is linked to photosensitivity reactions. You are advised to avoid sunlight, sunlamps, or tanning beds while using this treatment as Tolak can make your skin more sensitive to sunlight and cause it to sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) if you are going outdoors. Store the cream at room temperature away from moisture and heat.

Please read the patient information provided and always speak with a healthcare professional for medical advice about any changes to your dose so they can monitor and evaluate your condition.

Tolak active ingredients

Tolak contains fluorouracil as the active ingredient.

Tolak side effects

The most common side effects of Tolak cream in clinical trials include:

  • Skin reactions, such as pain, itching, burning, irritation, and inflammation
  • Hair loss
  • Dryness
  • Swelling
  • Tenderness and crusting at the site of application

In rare instances, Tolak can cause more serious side effects. These can include:

  • Severe pain, swelling, itching, burning, or irritation
  • New or worsening skin sores
  • Fever, chills
  • Severe abdominal pain, bloody diarrhea, vomiting

Your doctor will assess the benefits of using Tolak against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Tolak to the FDA. Visit, or call 1-800-FDA-1088.

Tolak drug interactions

Other drugs may interact with Tolak, including prescription drugs and over-the-counter medicines, vitamins, and herbal products. Tell your health care provider about all of your medication including any supplements you are taking.

Tolak contraindications

You should not use Tolak if you:

  • Are allergic to the active ingredient fluorouracil
  • Have had an allergic reaction to any of the other inactive ingredients in Tolak
  • Have DPD deficiency (dihydropyrimidine dehydrogenase)
  • Are allergic to peanut oil (Tolak contains peanut oil)
  • Are younger than 18 years of age
  • Are pregnant or are planning to become pregnant – Fluorouracil can cause harm to an unborn baby, such as birth defects and miscarriage, use effective birth control
  • Are breastfeeding or are planning to breastfeed – It is not known if this medication passes into breast milk

Talk to your doctor about your medical condition before using Tolak if you:

  • Are taking any of the medications that could interact with Tolak

Tolak generic

Tolak is the trademark brand name for fluorouracil cream manufactured by Hill Dermaceuticals. A generic version of fluorouracil is available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Tolak savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.